TY - JOUR
T1 - Novel and emerging treatments for major depression
AU - Marwaha, Steven
AU - Palmer, Edward
AU - Suppes, Trisha
AU - Cons, Emily
AU - Young, Allan H
AU - Upthegrove, Rachel
N1 - Copyright © 2022 Elsevier Ltd. All rights reserved.
PY - 2023/1/14
Y1 - 2023/1/14
N2 - Depression is common, costly, debilitating, and associated with increased risk of suicide. It is one of the leading global public health problems. Although existing available pharmacological treatments can be effective, their onset of action can take up to 6 weeks, side-effects are common, and recovery can require treatment with multiple different agents. Although psychosocial interventions might also be recommended, more effective treatments than those currently available are needed for people with moderate or severe depression. In the past 10 years, treatment trials have developed and tested many new targeted interventions. In this Review, we assess novel and emerging biological treatments for major depressive disorder, evaluate their putative brain and body mechanisms, and highlight how close each might be to clinical use.
AB - Depression is common, costly, debilitating, and associated with increased risk of suicide. It is one of the leading global public health problems. Although existing available pharmacological treatments can be effective, their onset of action can take up to 6 weeks, side-effects are common, and recovery can require treatment with multiple different agents. Although psychosocial interventions might also be recommended, more effective treatments than those currently available are needed for people with moderate or severe depression. In the past 10 years, treatment trials have developed and tested many new targeted interventions. In this Review, we assess novel and emerging biological treatments for major depressive disorder, evaluate their putative brain and body mechanisms, and highlight how close each might be to clinical use.
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-85146230128&partnerID=MN8TOARS
U2 - 10.1016/S0140-6736(22)02080-3
DO - 10.1016/S0140-6736(22)02080-3
M3 - Review article
C2 - 36535295
SN - 0140-6736
VL - 401
SP - 141
EP - 153
JO - The Lancet
JF - The Lancet
IS - 10371
ER -