Conflicts with transcription make early replication late

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• Active

  Integration of physiological tissue models and machine learning to understand genomic instability from oncogene activation to cancer initiation

  Parish, J. & Petermann, E.

  Medical Research Council

  1/06/22 → 31/05/25

  Project: Research Councils

• Understanding the unique properties of the Sin3A histone deacetylase complex in transcription and cell viability

  Petermann, E.

  Medical Research Council

  3/01/22 → 2/01/25

  Project: Research Councils

• Investigating the effects of a de-regulated transcription machinery on replication stress in cancer

  Kanhere, A. & Petermann, E.

  Cancer Research Uk

  1/09/19 → 31/08/25

  Project: Research

  • R-Loop Structures 100%
  • adducts 61%
  • DNA Adducts 58%
  • Homologous Recombination 52%
  • forks 47%
• Finished

  Characterising novel recombination pathways at DNA adducts of the environmental mutagen BDPE

  Petermann, E. & Piberger, L.

  Medical Research Council

  15/03/19 → 31/12/22

  Project: Research Councils

  • R-Loop Structures 100%
  • adducts 82%
  • DNA Adducts 77%
  • Homologous Recombination 70%
  • forks 63%