Matthias Soller – Network — University of Birmingham

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Accepting PhD Students

PhD projects

Matthias Soller’s primary research interest is how the information encoded in chromosomes instructs the building of the brain and allows an organism to perform elaborate tasks. His work focuses on post-transcriptionally controlled gene networks in neuronal development and function. Almost every gene is regulated at the post-transcriptional level in humans. Particularly important is the large number of genes that are alternatively spliced; and this type of gene regulation is most prevalently found in the brain. What are the functional consequences of this enormous increase in molecular diversity in neurons? How is alternative pre-mRNA processing co-ordinately regulated at a genomic level?

Dr Soller is using the fruit fly Drosophilawith its sophisticated genetic tools as a model to study alternative pre-mRNA processing. His favourite molecule to address how genes are co-ordinately regulated at the post-transcriptional level is the neuronal splicing regulator ELAV. The transcription factor EWG has been identified as a major target of ELAV. Through the analysis of EWG-regulated genes Dr Soller identified a prominent role of both ELAV and EWG in the regulation of structural plasticity at Drosophilasynapses.

Research activity per year

The University of Birmingham

Organisational unit: University

55 shared research output

Life and Environmental Sciences

The University of Birmingham

Organisational unit: College

55 shared research output

Medical and Dental Sciences

The University of Birmingham

Organisational unit: College

20 shared research output

Microbiology and Infection

Medical and Dental Sciences

Organisational unit: School

17 shared research output

Cancer and Genomic Sciences

Medical and Dental Sciences

Organisational unit: School

3 shared research output

University of Toulouse

External organisation: University or other Higher Education Institute

3 shared research output

University of Birmingham

External organisation: University or other Higher Education Institute

3 shared research output

Institute of Molecular Biology (IMB), Mainz

External organisation: No HESA Fund Source

3 shared research output

University of Nottingham

External organisation: University or other Higher Education Institute

2 shared research output

São Paulo State University

External organisation: University or other Higher Education Institute

1 shared research output

University of Ljubljana

External organisation: University or other Higher Education Institute

1 shared research output

University of Toronto

External organisation: University or other Higher Education Institute

1 shared research output

University of Debrecen

External organisation: University or other Higher Education Institute

1 shared research output

University of Manitoba

External organisation: University or other Higher Education Institute

1 shared research output

King’s College London

External organisation: University or other Higher Education Institute

1 shared research output

University of Aberdeen

External organisation: University or other Higher Education Institute

1 shared research output

Brandeis University

External organisation: University or other Higher Education Institute

1 shared research output

Genomic core facility, Institute of Molecular Biology (IMB), Mainz, 55128, Germany

External organisation: No award or financial backing

1 shared research output

Universidade Estadual Paulista

External organisation: University or other Higher Education Institute

1 shared research output

Johannes Gutenberg University

External organisation: University or other Higher Education Institute

1 shared research output

University of Cambridge

External organisation: University or other Higher Education Institute

1 shared research output

University of Kassel

External organisation: University or other Higher Education Institute

1 shared research output

Laboratory of RNA Epigenetics, Institute of Molecular Biology (IMB), Mainz, 55128, Germany

External organisation: No award or financial backing

1 shared research output

University of Montpellier

External organisation: University or other Higher Education Institute

1 shared research output

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland

External organisation: No award or financial backing

1 shared research output

University of Pavia

External organisation: University or other Higher Education Institute

1 shared research output

Birmingham City University

External organisation: University or other Higher Education Institute

1 shared research output

University of Basel

External organisation: University or other Higher Education Institute

1 shared research output

Coventry University

External organisation: University or other Higher Education Institute

1 shared research output