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Andrew Peet and his research group are developing novel imaging techniques for the diagnosis, management and understanding of childhood cancer. Magnetic Resonance Imaging (MRI) is a crucial investigation in children with solid tumours but whilst it provides images of superb clarity, it gives little information on how aggressive a tumour is or whether it will respond to treatment. The aim is to address these issues by developing non-invasive methods which can tailor the treatment to the individual patient.

The group’s research has concentrated on magnetic resonance spectroscopy, a technique which can be readily combined with MRI in the hospital but which provides a chemical profile of the tumour. These chemical profiles have been shown by the team to be useful as a diagnostic aid and this is becoming integrated into clinical practice. In addition, several biomarkers of tumour aggressiveness have been identified and evaluated. This is valuable information in making treatment decisions on patients. The expertise developed in Birmingham is being translated to other centres in the UK and beyond.

1992 …2024

Research activity per year

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  • 2019

    Methodological consensus on clinical proton MRS of the brain: review and recommendations

    Wilson, M., Andronesi, O., Barker, P. B., Bartha, R., Bizzi, A., Bolan, P. J., Brindle, K. M., Choi, I., Cudalbu, C., Dydak, U., Emir, U. E., Gonzalez, R. G., Gruber, S., Gruetter, R., Gupta, R. K., Heerschap, A., Henning, A., Hetherington, H. P., Huppi, P. S., Hurd, R. E., & 29 othersKantarci, K., Kauppinen, R. A., Klomp, D. W. J., Kreis, R., Kruiskamp, M. J., Leach, M. O., Lin, A. P., Luijten, P. R., Marjańska, M., Maudsley, A. A., Meyerhoff, D. J., Mountford, C. E., Mullins, P. G., Murdoch, J. B., Nelson, S. J., Noeske, R., Öz, G., Pan, J. W., Peet, A. C., Poptani, H., Posse, S., Ratai, E., Salibi, N., Scheenen, T. W. J., Smith, I. C. P., Soher, B. J., Tkáč, I., Vigneron, D. B. & Howe, F. A., Aug 2019, In: Magnetic Resonance in Medicine. 82, 2, p. 527-550 24 p.

    Research output: Contribution to journalReview articlepeer-review

    Open Access
    File
    74 Citations (Scopus)
    284 Downloads (Pure)
  • 2018

    The utility of routine surveillance screening with magnetic resonance imaging (MRI) to detect tumour recurrence in children with low-grade central nervous system (CNS) tumours: a systematic review

    Stevens, S. P., Main, C., Bailey, S., Pizer, B., English, M., Phillips, R., Peet, A., Avula, S., Wilne, S., Wheatley, K., Kearns, P. R. & Wilson, J. S., 1 Sept 2018, In: Journal of Neuro-Oncology. 139, 3, p. 507-522 16 p.

    Research output: Contribution to journalReview articlepeer-review

    Open Access
    File
    6 Citations (Scopus)
    140 Downloads (Pure)
  • 2017

    Imaging biomarker roadmap for cancer studies

    O'Connor, J. P. B., Aboagye, E. O., Adams, J. E., Aerts, H. J. W. L., Barrington, S. F., Beer, A. J., Boellaard, R., Bohndiek, S. E., Brady, M., Brown, G., Buckley, D. L., Chenevert, T. L., Clarke, L. P., Collette, S., Cook, G. J., deSouza, N. M., Dickson, J. C., Dive, C., Evelhoch, J. L., Faivre-Finn, C., & 57 othersGallagher, F. A., Gilbert, F. J., Gillies, R. J., Goh, V., Griffiths, J. R., Groves, A. M., Halligan, S., Harris, A. L., Hawkes, D. J., Hoekstra, O. S., Huang, E. P., Hutton, B. F., Jackson, E. F., Jayson, G. C., Jones, A., Koh, D-M., Lacombe, D., Lambin, P., Lassau, N., Leach, M. O., Lee, T-Y., Leen, E. L., Lewis, J. S., Liu, Y., Lythgoe, M. F., Manoharan, P., Maxwell, R. J., Miles, K. A., Morgan, B., Morris, S., Ng, T., Padhani, A. R., Parker, G. J. M., Partridge, M., Pathak, A. P., Peet, A. C., Punwani, S., Reynolds, A. R., Robinson, S. P., Shankar, L. K., Sharma, R. A., Soloviev, D., Stroobants, S., Sullivan, D. C., Taylor, S. A., Tofts, P. S., Tozer, G. M., van Herk, M., Walker-Samuel, S., Wason, J., Williams, K. J., Workman, P., Yankeelov, T. E., Brindle, K. M., McShane, L. M., Jackson, A. & Waterton, J. C., Mar 2017, In: Nature Reviews Clinical Oncology. 14, 3, p. 169-186 18 p.

    Research output: Contribution to journalReview articlepeer-review

    Open Access
    File
    412 Citations (Scopus)
    163 Downloads (Pure)
  • Magnetic resonance imaging based functional imaging in paediatric oncology

    Manias, K. A., Gill, S. K., MacPherson, L., Foster, K., Oates, A. & Peet, A. C., Feb 2017, In: European Journal of Cancer. 72, p. 251-265 15 p.

    Research output: Contribution to journalReview articlepeer-review

    9 Citations (Scopus)
  • 2014

    Clinical proton MR spectroscopy in central nervous system disorders

    Oz, G., Alger, J. R., Barker, P. B., Bartha, R., Bizzi, A., Boesch, C., Bolan, P. J., Brindle, K. M., Cudalbu, C., Dinçer, A., Dydak, U., Emir, U. E., Frahm, J., González, R. G., Gruber, S., Gruetter, R., Gupta, R. K., Heerschap, A., Henning, A., Hetherington, H. P., & 31 othersHowe, F. A., Hüppi, P. S., Hurd, R. E., Kantarci, K., Klomp, D. W. J., Kreis, R., Kruiskamp, M. J., Leach, M. O., Lin, A. P., Luijten, P. R., Marjańska, M., Maudsley, A. A., Meyerhoff, D. J., Mountford, C. E., Nelson, S. J., Pamir, M. N., Pan, J. W., Peet, A. C., Poptani, H., Posse, S., Pouwels, P. J. W., Ratai, E-M., Ross, B. D., Scheenen, T. W., Schuster, C., Smith, I. C. P., Soher, B. J., Tkáč, I., Vigneron, D. B., Kauppinen, R. A. & MRS Consensus Group, 1 Mar 2014, In: Radiology. 270, 3, p. 658-679 22 p.

    Research output: Contribution to journalReview articlepeer-review

    307 Citations (Scopus)
  • 2012

    Functional imaging in adult and paediatric brain tumours

    Peet, A. C., Arvanitis, T. N., Leach, M. O. & Waldman, A. D., Dec 2012, In: Nature Reviews Clinical Oncology. 9, 12, p. 700-11 12 p.

    Research output: Contribution to journalReview articlepeer-review

    41 Citations (Scopus)
  • 2011

    A knowledge-rich distributed decision support framework: a case study for brain tumour diagnosis

    Dupplaw, D., Croitoru, M., Dasmahapatra, S., Gibb, A., Gonzalez-Velez, H., Lurgi, M., Hu, B., Lewis, P. & Peet, A., 1 Sept 2011, In: Knowledge Engineering Review. 26, 3, p. 247-260 14 p.

    Research output: Contribution to journalReview articlepeer-review

    Open Access
    File
    1 Citation (Scopus)
    430 Downloads (Pure)
  • The design and implementation of a novel security model for HealthAgents

    Xiao, L., Dasmahapatra, S., Lewis, P., Hu, B., Peet, A., Gibb, A., Dupplaw, D., Croitoru, M., Estanyol, F., Martinez-Miranda, J., Gonzalez-Velez, H. & Ariet, MI., 1 Sept 2011, In: Knowledge Engineering Review. 26, 3, p. 261-282 22 p.

    Research output: Contribution to journalReview articlepeer-review

    Open Access
    File
    3 Citations (Scopus)
    7620 Downloads (Pure)