TY - JOUR
T1 - Extended interval BNT162b2 vaccination enhances peak antibody generation
AU - Parry, Helen
AU - Moss, Paul
AU - Stephens, Christine
AU - Bentley, Christopher
AU - Brown, Kevin
AU - Amirthalingam, Gayatri
AU - Hallis, Bassam
AU - Otter, Ashley
AU - Zuo, Jianmin
AU - Moss, Paul
N1 - © 2022. The Author(s).
PY - 2022/1/27
Y1 - 2022/1/27
N2 - The BNT162b2 vaccine is highly effective against COVID-19 infection and was delivered with a 3-week time interval in registration studies1. However, many countries extended this interval to accelerate population coverage with a single vaccine. It is not known how immune responses are influenced by delaying the second dose. We provide the assessment of immune responses in the first 14 weeks after standard or extended-interval BNT162b2 vaccination and show that delaying the second dose strongly boosts the peak antibody response by 3.5-fold in older people. This enhanced antibody response may offer a longer period of clinical protection and delay the need for booster vaccination. In contrast, peak cellular-specific responses were the strongest in those vaccinated on a standard 3-week vaccine interval. As such, the timing of the second dose has a marked influence on the kinetics and magnitude of the adaptive immune response after mRNA vaccination in older people.
AB - The BNT162b2 vaccine is highly effective against COVID-19 infection and was delivered with a 3-week time interval in registration studies1. However, many countries extended this interval to accelerate population coverage with a single vaccine. It is not known how immune responses are influenced by delaying the second dose. We provide the assessment of immune responses in the first 14 weeks after standard or extended-interval BNT162b2 vaccination and show that delaying the second dose strongly boosts the peak antibody response by 3.5-fold in older people. This enhanced antibody response may offer a longer period of clinical protection and delay the need for booster vaccination. In contrast, peak cellular-specific responses were the strongest in those vaccinated on a standard 3-week vaccine interval. As such, the timing of the second dose has a marked influence on the kinetics and magnitude of the adaptive immune response after mRNA vaccination in older people.
UR - http://www.scopus.com/inward/record.url?scp=85123761133&partnerID=8YFLogxK
U2 - 10.1038/s41541-022-00432-w
DO - 10.1038/s41541-022-00432-w
M3 - Article
C2 - 35087066
SN - 2059-0105
VL - 7
JO - NPJ vaccines
JF - NPJ vaccines
IS - 1
M1 - 14
ER -
