Design and Synthesis of a Water-Based Nanodelivery Pesticide System for Improved Efficacy and Safety

Changcheng An; Bingna Huang; Jiajun Jiang; Xinyue Wang; Ningjun Li; Huihui Liu; Yue Shen; Changjiao Sun; Shenshan Zhan; Xingye Li; Chong Wang; Zhanghua Zeng; Haixin Cui; Qingjun Wu; Youjun Zhang; Zhiling Guo; Peng Zhang; Iseult Lynch; Jin-Ming Gao; Yan Wang

doi:10.1021/acsnano.3c08854

Design and Synthesis of a Water-Based Nanodelivery Pesticide System for Improved Efficacy and Safety

Changcheng An, Bingna Huang, Jiajun Jiang, Xinyue Wang, Ningjun Li, Huihui Liu, Yue Shen, Changjiao Sun, Shenshan Zhan, Xingye Li, Chong Wang, Zhanghua Zeng, Haixin Cui, Qingjun Wu, Youjun Zhang, Zhiling Guo, Peng Zhang, Iseult Lynch, Jin-Ming Gao^*, Yan Wang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Developing an environmentally friendly and safe nanodelivery system is crucial to improve the efficacy of pesticides and minimize environmental and health risks. However, preparing a completely water-based nanopesticide without using harmful solvents is a technical challenge. In this study, a water-based nanodelivery pesticide system was constructed to improve the efficacy and safety of Emamectin Benzoate (EB). A specific surfactant, 29-(4-(5-hydroxynonan-5-yl)phenoxy)-3,6,9,12,15,18,21,24,27-nonaoxanonacosan-1-ol (SurEB) was designed and synthesized to form a water-based nanodelivery system (EBWNS) with EB. Molecular dynamics simulations revealed the self-assembly and interaction forces between SurEB and EB in water, providing insights into the formation mechanism of EBWNS nanoparticles. The nanodelivery system showed the prolonged effectivity of EB with reduced degradation and demonstrated a good control efficacy for multiple target pests, such as red spider mite, beet armyworm larvae (Lepidoptera: Noctuidae), and rice stem borers (Chilo suppressalis). Toxicology tests on various objects demonstrated that the EBWNS has low toxicity for seeds, HaCaT cells, zebrafish, earthworm, and E. coli. This study provides a distinctive perspective for developing environmentally friendly nanopesticide formulations, which clarified a water-based treatment method for specific lipid-soluble pesticides. The water-based nanodelivery pesticide system has the potential to improve the efficacy and safety of pesticides in the process of field applications.

Original language	English
Pages (from-to)	662-679
Number of pages	18
Journal	ACS Nano
Volume	18
Issue number	1
Early online date	22 Dec 2023
DOIs	https://doi.org/10.1021/acsnano.3c08854
Publication status	Published - 9 Jan 2024

Bibliographical note

Acknowledgments:
We are grateful for financial support from the National Key R&D Program of China (2022YFD1401200, 2021YFA0716700, 2023YFD1700300), the National Support Program for High-level Talents, the National Natural Science Foundation of China (31701825), the Central Public-interest Scientific Institution Basal Research Fund (No. BSRF202113), and the Agricultural Science and Technology Innovation Program.

Keywords

Emamectin benzoate
Water based nanodelivery
Molecular dynamics
Environmentally friendly
Pesticide formulation
Sustainable agriculture

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/acsnano.3c08854

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AnC2023Design_AAM
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Embargo ends: 22/12/24

Cite this

An, C., Huang, B., Jiang, J., Wang, X., Li, N., Liu, H., Shen, Y., Sun, C., Zhan, S., Li, X., Wang, C., Zeng, Z., Cui, H., Wu, Q., Zhang, Y., Guo, Z., Zhang, P., Lynch, I., Gao, J.-M., & Wang, Y. (2024). Design and Synthesis of a Water-Based Nanodelivery Pesticide System for Improved Efficacy and Safety. ACS Nano, 18(1), 662-679. https://doi.org/10.1021/acsnano.3c08854

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title = "Design and Synthesis of a Water-Based Nanodelivery Pesticide System for Improved Efficacy and Safety",

abstract = "Developing an environmentally friendly and safe nanodelivery system is crucial to improve the efficacy of pesticides and minimize environmental and health risks. However, preparing a completely water-based nanopesticide without using harmful solvents is a technical challenge. In this study, a water-based nanodelivery pesticide system was constructed to improve the efficacy and safety of Emamectin Benzoate (EB). A specific surfactant, 29-(4-(5-hydroxynonan-5-yl)phenoxy)-3,6,9,12,15,18,21,24,27-nonaoxanonacosan-1-ol (SurEB) was designed and synthesized to form a water-based nanodelivery system (EBWNS) with EB. Molecular dynamics simulations revealed the self-assembly and interaction forces between SurEB and EB in water, providing insights into the formation mechanism of EBWNS nanoparticles. The nanodelivery system showed the prolonged effectivity of EB with reduced degradation and demonstrated a good control efficacy for multiple target pests, such as red spider mite, beet armyworm larvae (Lepidoptera: Noctuidae), and rice stem borers (Chilo suppressalis). Toxicology tests on various objects demonstrated that the EBWNS has low toxicity for seeds, HaCaT cells, zebrafish, earthworm, and E. coli. This study provides a distinctive perspective for developing environmentally friendly nanopesticide formulations, which clarified a water-based treatment method for specific lipid-soluble pesticides. The water-based nanodelivery pesticide system has the potential to improve the efficacy and safety of pesticides in the process of field applications. ",

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author = "Changcheng An and Bingna Huang and Jiajun Jiang and Xinyue Wang and Ningjun Li and Huihui Liu and Yue Shen and Changjiao Sun and Shenshan Zhan and Xingye Li and Chong Wang and Zhanghua Zeng and Haixin Cui and Qingjun Wu and Youjun Zhang and Zhiling Guo and Peng Zhang and Iseult Lynch and Jin-Ming Gao and Yan Wang",

note = "Acknowledgments: We are grateful for financial support from the National Key R&D Program of China (2022YFD1401200, 2021YFA0716700, 2023YFD1700300), the National Support Program for High-level Talents, the National Natural Science Foundation of China (31701825), the Central Public-interest Scientific Institution Basal Research Fund (No. BSRF202113), and the Agricultural Science and Technology Innovation Program.",

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AU - An, Changcheng

AU - Huang, Bingna

AU - Jiang, Jiajun

AU - Wang, Xinyue

AU - Li, Ningjun

AU - Liu, Huihui

AU - Shen, Yue

AU - Sun, Changjiao

AU - Zhan, Shenshan

AU - Li, Xingye

AU - Wang, Chong

AU - Zeng, Zhanghua

AU - Cui, Haixin

AU - Wu, Qingjun

AU - Zhang, Youjun

AU - Guo, Zhiling

AU - Zhang, Peng

AU - Lynch, Iseult

AU - Gao, Jin-Ming

AU - Wang, Yan

N1 - Acknowledgments: We are grateful for financial support from the National Key R&D Program of China (2022YFD1401200, 2021YFA0716700, 2023YFD1700300), the National Support Program for High-level Talents, the National Natural Science Foundation of China (31701825), the Central Public-interest Scientific Institution Basal Research Fund (No. BSRF202113), and the Agricultural Science and Technology Innovation Program.

PY - 2024/1/9

Y1 - 2024/1/9

N2 - Developing an environmentally friendly and safe nanodelivery system is crucial to improve the efficacy of pesticides and minimize environmental and health risks. However, preparing a completely water-based nanopesticide without using harmful solvents is a technical challenge. In this study, a water-based nanodelivery pesticide system was constructed to improve the efficacy and safety of Emamectin Benzoate (EB). A specific surfactant, 29-(4-(5-hydroxynonan-5-yl)phenoxy)-3,6,9,12,15,18,21,24,27-nonaoxanonacosan-1-ol (SurEB) was designed and synthesized to form a water-based nanodelivery system (EBWNS) with EB. Molecular dynamics simulations revealed the self-assembly and interaction forces between SurEB and EB in water, providing insights into the formation mechanism of EBWNS nanoparticles. The nanodelivery system showed the prolonged effectivity of EB with reduced degradation and demonstrated a good control efficacy for multiple target pests, such as red spider mite, beet armyworm larvae (Lepidoptera: Noctuidae), and rice stem borers (Chilo suppressalis). Toxicology tests on various objects demonstrated that the EBWNS has low toxicity for seeds, HaCaT cells, zebrafish, earthworm, and E. coli. This study provides a distinctive perspective for developing environmentally friendly nanopesticide formulations, which clarified a water-based treatment method for specific lipid-soluble pesticides. The water-based nanodelivery pesticide system has the potential to improve the efficacy and safety of pesticides in the process of field applications.

AB - Developing an environmentally friendly and safe nanodelivery system is crucial to improve the efficacy of pesticides and minimize environmental and health risks. However, preparing a completely water-based nanopesticide without using harmful solvents is a technical challenge. In this study, a water-based nanodelivery pesticide system was constructed to improve the efficacy and safety of Emamectin Benzoate (EB). A specific surfactant, 29-(4-(5-hydroxynonan-5-yl)phenoxy)-3,6,9,12,15,18,21,24,27-nonaoxanonacosan-1-ol (SurEB) was designed and synthesized to form a water-based nanodelivery system (EBWNS) with EB. Molecular dynamics simulations revealed the self-assembly and interaction forces between SurEB and EB in water, providing insights into the formation mechanism of EBWNS nanoparticles. The nanodelivery system showed the prolonged effectivity of EB with reduced degradation and demonstrated a good control efficacy for multiple target pests, such as red spider mite, beet armyworm larvae (Lepidoptera: Noctuidae), and rice stem borers (Chilo suppressalis). Toxicology tests on various objects demonstrated that the EBWNS has low toxicity for seeds, HaCaT cells, zebrafish, earthworm, and E. coli. This study provides a distinctive perspective for developing environmentally friendly nanopesticide formulations, which clarified a water-based treatment method for specific lipid-soluble pesticides. The water-based nanodelivery pesticide system has the potential to improve the efficacy and safety of pesticides in the process of field applications.

KW - Emamectin benzoate

KW - Water based nanodelivery

KW - Molecular dynamics

KW - Environmentally friendly

KW - Pesticide formulation

KW - Sustainable agriculture

U2 - 10.1021/acsnano.3c08854

DO - 10.1021/acsnano.3c08854

M3 - Article

C2 - 38134332

SN - 1936-0851

VL - 18

SP - 662

EP - 679

JO - ACS Nano

JF - ACS Nano

IS - 1

ER -

Design and Synthesis of a Water-Based Nanodelivery Pesticide System for Improved Efficacy and Safety

Abstract

Bibliographical note

Keywords

UN SDGs

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