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Abstract
Carbapenem-resistant Escherichia coli (CREC) ST410 has recently emerged as a major global health problem. Here, we report a shift in CREC prevalence in Chinese hospitals between 2017 and 2021 with ST410 becoming the most commonly isolated sequence type. Genomic analysis identifies a hypervirulent CREC ST410 clone, B5/H24RxC, which caused two separate outbreaks in a children's hospital. It may have emerged from the previously characterised B4/H24RxC in 2006 and has been isolated in ten other countries from 2015 to 2021. Compared with B4/H24RxC, B5/H24RxC lacks the blaOXA-181-bearing X3 plasmid, but carries a F-type plasmid containing blaNDM-5. Most of B5/H24RxC also carry a high pathogenicity island and a novel O-antigen gene cluster. We find that B5/H24RxC grew faster in vitro and is more virulent in vivo. The identification of this newly emerged but already globally disseminated hypervirulent CREC clone, highlights the ongoing evolution of ST410 towards increased resistance and virulence.
Original language | English |
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Article number | 494 |
Number of pages | 15 |
Journal | Nature Communications |
Volume | 15 |
Issue number | 1 |
Early online date | 12 Jan 2024 |
DOIs | |
Publication status | Published - 12 Jan 2024 |
Bibliographical note
Acknowledgements:This work was undertaken as part of the DETECTIVE research project funded by the National Natural Science Foundation of China (8181101332) and the Medical Research Council (MR/S013660/1). W.v.S. was also supported by a Wolfson Research Merit Award (WM160092). We thank Dr. Andries J. van Tonder for guidance on the bioinformatics analysis.
Copyright:
© 2024. The Author(s).
Keywords
- Child
- Humans
- Escherichia coli/genetics
- Escherichia coli Infections/epidemiology
- Carbapenem-Resistant Enterobacteriaceae/genetics
- Clone Cells
- Carbapenems/pharmacology
- Anti-Bacterial Agents/pharmacology
- beta-Lactamases/genetics
- Microbial Sensitivity Tests
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Dive into the research topics of 'Global emergence of a hypervirulent carbapenem-resistant Escherichia coli ST410 clone'. Together they form a unique fingerprint.Projects
- 2 Finished
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DETECTIVE: Dissemination and resistance mechanisms of carbapenem-resistant Gram-negative bacilli
14/02/19 → 31/03/23
Project: Research Councils
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Acquisition of antimicrobial resistance by opportunistic pathogens.
van Schaik, W. & Henderson, I.
1/05/17 → 30/04/22
Project: Research Councils