COVID-19 in children with haematological malignancies

Gerard Cathal Millen; Roland Arnold; Jean-Baptiste Cazier; Helen Curley; Richard Feltbower; Ashley Gamble; Adam Glaser; Richard G Grundy; Laura Kirton; Lennard Y W Lee; Martin G McCabe; Claire Palles; Bob Phillips; Charles A Stiller; Csilla Varnai; Pamela Kearns

doi:10.1136/archdischild-2021-322062

COVID-19 in children with haematological malignancies

Gerard Cathal Millen, Roland Arnold, Jean-Baptiste Cazier, Helen Curley, Richard Feltbower, Ashley Gamble, Adam Glaser, Richard G Grundy, Laura Kirton, Lennard Y W Lee, Martin G McCabe, Claire Palles, Bob Phillips, Charles A Stiller, Csilla Varnai, Pamela Kearns

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Abstract

Background

Children with cancer are not at increased risk of severe SARS-CoV-2 infection; however, adults with haematological malignancies have increased risk of severe infections compared with non-haematological malignancies.

Methods

We compared patients with haematological and non-haematological malignancies enrolled in the UK Paediatric Coronavirus Cancer Monitoring Project between 12 March 2020 and 16 February 2021. Children who received stem cell transplantation were excluded.

Results

Only 2/62 patients with haematological malignancy had severe/critical infections, with an OR of 0.5 for patients with haematological compared with non-haematological malignancies.

Interpretation

Children with haematological malignancies are at no greater risk of severe SARS-CoV-2 infection than those with non-haematological malignancies.

Data availability statement

Data are available on reasonable request. The database contains de-identified participant data which are anonymised at source prior to upload. Reasonable requests for data sharing will be considered.

Original language	English
Pages (from-to)	186-188
Number of pages	3
Journal	Archives of Disease in Childhood
Volume	107
Issue number	2
Early online date	22 Jul 2021
DOIs	https://doi.org/10.1136/archdischild-2021-322062
Publication status	Published - 1 Feb 2022

Bibliographical note

Publisher Copyright:
© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ.

Funding Information:
University of Birmingham provided the database and bio-informatics support, GCM is partially funded by a Cancer Research UK grant (A30259). This paper presents independent research supported by the National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre (Grant Reference Number BRC-1215-20009).

Keywords

Covid-19
Data collection
Epidemiology
COVID-19
epidemiology
data collection
Severity of Illness Index
Humans
Risk Factors
Risk Assessment/statistics & numerical data
Child, Preschool
Infant
Male
COVID-19/diagnosis
SARS-CoV-2/immunology
Adolescent
Hematologic Neoplasms/epidemiology
Female
Child
Cohort Studies

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1136/archdischild-2021-322062Licence: Creative Commons: Attribution (CC BY)

MillenG2022COVIDFinal published version, 291 KBLicence: Creative Commons: Attribution (CC BY)

Cite this

Millen, G. C., Arnold, R., Cazier, J-B., Curley, H., Feltbower, R., Gamble, A., Glaser, A., Grundy, R. G., Kirton, L., Lee, L. Y. W., McCabe, M. G., Palles, C., Phillips, B., Stiller, C. A., Varnai, C., & Kearns, P. (2022). COVID-19 in children with haematological malignancies. Archives of Disease in Childhood, 107(2), 186-188. Advance online publication. https://doi.org/10.1136/archdischild-2021-322062

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abstract = "Background Children with cancer are not at increased risk of severe SARS-CoV-2 infection; however, adults with haematological malignancies have increased risk of severe infections compared with non-haematological malignancies.Methods We compared patients with haematological and non-haematological malignancies enrolled in the UK Paediatric Coronavirus Cancer Monitoring Project between 12 March 2020 and 16 February 2021. Children who received stem cell transplantation were excluded.Results Only 2/62 patients with haematological malignancy had severe/critical infections, with an OR of 0.5 for patients with haematological compared with non-haematological malignancies.Interpretation Children with haematological malignancies are at no greater risk of severe SARS-CoV-2 infection than those with non-haematological malignancies.Data availability statementData are available on reasonable request. The database contains de-identified participant data which are anonymised at source prior to upload. Reasonable requests for data sharing will be considered.",

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note = "Publisher Copyright: {\textcopyright} Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ. Funding Information: University of Birmingham provided the database and bio-informatics support, GCM is partially funded by a Cancer Research UK grant (A30259). This paper presents independent research supported by the National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre (Grant Reference Number BRC-1215-20009). ",

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AU - Millen, Gerard Cathal

AU - Arnold, Roland

AU - Cazier, Jean-Baptiste

AU - Curley, Helen

AU - Feltbower, Richard

AU - Gamble, Ashley

AU - Glaser, Adam

AU - Grundy, Richard G

AU - Kirton, Laura

AU - Lee, Lennard Y W

AU - McCabe, Martin G

AU - Palles, Claire

AU - Phillips, Bob

AU - Stiller, Charles A

AU - Varnai, Csilla

AU - Kearns, Pamela

N1 - Publisher Copyright: © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ. Funding Information: University of Birmingham provided the database and bio-informatics support, GCM is partially funded by a Cancer Research UK grant (A30259). This paper presents independent research supported by the National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre (Grant Reference Number BRC-1215-20009).

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Y1 - 2022/2/1

N2 - Background Children with cancer are not at increased risk of severe SARS-CoV-2 infection; however, adults with haematological malignancies have increased risk of severe infections compared with non-haematological malignancies.Methods We compared patients with haematological and non-haematological malignancies enrolled in the UK Paediatric Coronavirus Cancer Monitoring Project between 12 March 2020 and 16 February 2021. Children who received stem cell transplantation were excluded.Results Only 2/62 patients with haematological malignancy had severe/critical infections, with an OR of 0.5 for patients with haematological compared with non-haematological malignancies.Interpretation Children with haematological malignancies are at no greater risk of severe SARS-CoV-2 infection than those with non-haematological malignancies.Data availability statementData are available on reasonable request. The database contains de-identified participant data which are anonymised at source prior to upload. Reasonable requests for data sharing will be considered.

AB - Background Children with cancer are not at increased risk of severe SARS-CoV-2 infection; however, adults with haematological malignancies have increased risk of severe infections compared with non-haematological malignancies.Methods We compared patients with haematological and non-haematological malignancies enrolled in the UK Paediatric Coronavirus Cancer Monitoring Project between 12 March 2020 and 16 February 2021. Children who received stem cell transplantation were excluded.Results Only 2/62 patients with haematological malignancy had severe/critical infections, with an OR of 0.5 for patients with haematological compared with non-haematological malignancies.Interpretation Children with haematological malignancies are at no greater risk of severe SARS-CoV-2 infection than those with non-haematological malignancies.Data availability statementData are available on reasonable request. The database contains de-identified participant data which are anonymised at source prior to upload. Reasonable requests for data sharing will be considered.

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ER -

COVID-19 in children with haematological malignancies

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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Cite this