Abstract
Objective: To provide an update on the evidence base for the nature of the relationship between negative symptoms and depressive features in people with schizophrenia, and propose new models that reflect their complex relationship. Method: A systematic review following PRISMA guidelines. A total of 2210 articles were identified from EMBASE, PsychInfo and MEDLINE, and further two articles were hand-searched from references. Twenty-seven met inclusion criteria and were included in the review. Results: In schizophrenia, primary evidence suggests symptoms of low mood, suicidal ideation and pessimism have more specificity for depression whereas alogia and blunted affect may have more specificity as negative symptoms. Anhedonia, anergia and avolition may be common to both. Conclusion: It may be possible to further distinguish depressive features from negative symptoms in schizophrenia when detailed phenomenology is considered. However, in a proposed dimensional model, these two domains continue to share certain phenomena, highlighting their close relationship.
| Original language | English |
|---|---|
| Pages (from-to) | 380-390 |
| Journal | Acta Psychiatrica Scandinavica |
| Volume | 137 |
| Issue number | 5 |
| Early online date | 13 Mar 2018 |
| DOIs | |
| Publication status | E-pub ahead of print - 13 Mar 2018 |
Keywords
- Depression
- Schizophrenia
ASJC Scopus subject areas
- Psychiatry and Mental health
Access to Document
- Krynicki_et_al_The_relationship_between_Acta_Psychiatrica_Scandinavica_2018
Checked for eligibility: 13/04/2018 This is the peer reviewed version of the following article: Krynicki CR, Upthegrove R, Deakin JFW, Barnes TRE. The relationship between negative symptoms and depression in schizophrenia: a systematic review., which has been published in final form at https://doi.org/10.1111/acps.12873. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.