Abstract
Pyruvate kinase (PK) is the final and rate-limiting enzyme in glycolysis. It has four isoforms PKM1, PKM2, PKL and PKR. PK can form homo tetramers, dimers or monomers. The tetrameric form has the most catalytic activity; however, the dimeric form has non-canonical functions that contribute to the inflammatory response, wound healing and cellular crosstalk. This brief review explores these functions and speculates on their role in periodontal disease.
Original language | English |
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Article number | 784 |
Pages (from-to) | 784 |
Number of pages | 6 |
Journal | Pathogens |
Volume | 10 |
Issue number | 7 |
DOIs | |
Publication status | Published - 22 Jun 2021 |
Keywords
- glycolysis
- inflammation
- pyruvate kinase
- regulation