Versailles project on advanced materials and standards (VAMAS) interlaboratory study on measuring the number concentration of colloidal gold nanoparticles

Caterina Minelli; Magdalena Wywijas; Dorota Bartczak; Susana Cuello-Nuñez; Heidi Goenaga Infante; Jerome Deumer; Christian Gollwitzer; Michael Krumrey; Karen E Murphy; Monique E Johnson; Antonio R Montoro Bustos; Ingo H Strenge; Bertrand Faure; Peter Høghøj; Vivian Tong; Loïc Burr; Karin Norling; Fredrik Höök; Matthias Roesslein; Jovana Kocic; Lyndsey Hendriks; Vikram Kestens; Yannic Ramaye; Maria C Contreras Lopez; Guy Auclair; Dora Mehn; Douglas Gilliland; Annegret Potthoff; Kathrin Oelschlägel; Jutta Tentschert; Harald Jungnickel; Benjamin C Krause; Yves U Hachenberger; Philipp Reichardt; Andreas Luch; Thomas E Whittaker; Molly M Stevens; Shalini Gupta; Akash Singh; Fang-Hsin Lin; Yi-Hung Liu; Anna Luisa Costa; Carlo Baldisserri; Rid Jawad; Samir E L Andaloussi; Margaret N Holme; Tae Geol Lee; Minjeong Kwak; Jaeseok Kim; Johanna Ziebel; Cedric Guignard; Sebastien Cambier; Servane Contal; Arno C Gutleb; Jan Kuba Tatarkiewicz; Bartłomiej J Jankiewicz; Bartosz Bartosewicz; Xiaochun Wu; Jeffrey A Fagan; Elisabeth Elje; Elise Rundén-Pran; Maria Dusinska; Inder Preet Kaur; David Price; Ian Nesbitt; Sarah O Reilly; Ruud J B Peters; Guillaume Bucher; Dennis Coleman; Angela J Harrison; Antoine Ghanem; Anne Gering; Eileen McCarron; Niamh Fitzgerald; Geert Cornelis; Jani Tuoriniemi; Midori Sakai; Hidehisa Tsuchida; Ciarán Maguire; Adriele Prina-Mello; Alan J Lawlor; Jessica Adams; Carolin L Schultz; Doru Constantin; Nguyen Thi Kim Thanh; Le Duc Tung; Luca Panariello; Spyridon Damilos; Asterios Gavriilidis; Iseult Lynch; Benjamin Fryer; Ana Carrazco Quevedo; Emily Guggenheim; Sophie Briffa; Eugenia Valsami-Jones; Yuxiong Huang; Arturo A Keller; Virva-Tuuli Kinnunen; Siiri Perämäki; Zeljka Krpetic; Michael Greenwood; Alexander G Shard

doi:10.1039/d1nr07775a

Versailles project on advanced materials and standards (VAMAS) interlaboratory study on measuring the number concentration of colloidal gold nanoparticles

Caterina Minelli, Magdalena Wywijas, Dorota Bartczak, Susana Cuello-Nuñez, Heidi Goenaga Infante, Jerome Deumer, Christian Gollwitzer, Michael Krumrey, Karen E Murphy, Monique E Johnson, Antonio R Montoro Bustos, Ingo H Strenge, Bertrand Faure, Peter Høghøj, Vivian Tong, Loïc Burr, Karin Norling, Fredrik Höök, Matthias Roesslein, Jovana KocicLyndsey Hendriks, Vikram Kestens, Yannic Ramaye, Maria C Contreras Lopez, Guy Auclair, Dora Mehn, Douglas Gilliland, Annegret Potthoff, Kathrin Oelschlägel, Jutta Tentschert, Harald Jungnickel, Benjamin C Krause, Yves U Hachenberger, Philipp Reichardt, Andreas Luch, Thomas E Whittaker, Molly M Stevens, Shalini Gupta, Akash Singh, Fang-Hsin Lin, Yi-Hung Liu, Anna Luisa Costa, Carlo Baldisserri, Rid Jawad, Samir E L Andaloussi, Margaret N Holme, Tae Geol Lee, Minjeong Kwak, Jaeseok Kim, Johanna Ziebel, Cedric Guignard, Sebastien Cambier, Servane Contal, Arno C Gutleb, Jan Kuba Tatarkiewicz, Bartłomiej J Jankiewicz, Bartosz Bartosewicz, Xiaochun Wu, Jeffrey A Fagan, Elisabeth Elje, Elise Rundén-Pran, Maria Dusinska, Inder Preet Kaur, David Price, Ian Nesbitt, Sarah O Reilly, Ruud J B Peters, Guillaume Bucher, Dennis Coleman, Angela J Harrison, Antoine Ghanem, Anne Gering, Eileen McCarron, Niamh Fitzgerald, Geert Cornelis, Jani Tuoriniemi, Midori Sakai, Hidehisa Tsuchida, Ciarán Maguire, Adriele Prina-Mello, Alan J Lawlor, Jessica Adams, Carolin L Schultz, Doru Constantin, Nguyen Thi Kim Thanh, Le Duc Tung, Luca Panariello, Spyridon Damilos, Asterios Gavriilidis, Iseult Lynch, Benjamin Fryer, Ana Carrazco Quevedo, Emily Guggenheim, Sophie Briffa, Eugenia Valsami-Jones, Yuxiong Huang, Arturo A Keller, Virva-Tuuli Kinnunen, Siiri Perämäki, Zeljka Krpetic, Michael Greenwood, Alexander G Shard

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Abstract

We describe the outcome of a large international interlaboratory study of the measurement of particle number concentration of colloidal nanoparticles, project 10 of the technical working area 34, "Nanoparticle Populations" of the Versailles Project on Advanced Materials and Standards (VAMAS). A total of 50 laboratories delivered results for the number concentration of 30 nm gold colloidal nanoparticles measured using particle tracking analysis (PTA), single particle inductively coupled plasma mass spectrometry (spICP-MS), ultraviolet-visible (UV-Vis) light spectroscopy, centrifugal liquid sedimentation (CLS) and small angle X-ray scattering (SAXS). The study provides quantitative data to evaluate the repeatability of these methods and their reproducibility in the measurement of number concentration of model nanoparticle systems following a common measurement protocol. We find that the population-averaging methods of SAXS, CLS and UV-Vis have high measurement repeatability and reproducibility, with between-labs variability of 2.6%, 11% and 1.4% respectively. However, results may be significantly biased for reasons including inaccurate material properties whose values are used to compute the number concentration. Particle-counting method results are less reproducibile than population-averaging methods, with measured between-labs variability of 68% and 46% for PTA and spICP-MS respectively. This study provides the stakeholder community with important comparative data to underpin measurement reproducibility and method validation for number concentration of nanoparticles.

Original language	English
Article number	d1nr07775a
Pages (from-to)	4690-4704
Number of pages	15
Journal	Nanoscale
Volume	14
Issue number	12
Early online date	9 Mar 2022
DOIs	https://doi.org/10.1039/d1nr07775a
Publication status	E-pub ahead of print - 9 Mar 2022

ASJC Scopus subject areas

Materials Science(all)

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Minelli, C., Wywijas, M., Bartczak, D., Cuello-Nuñez, S., Infante, H. G., Deumer, J., Gollwitzer, C., Krumrey, M., Murphy, K. E., Johnson, M. E., Montoro Bustos, A. R., Strenge, I. H., Faure, B., Høghøj, P., Tong, V., Burr, L., Norling, K., Höök, F., Roesslein, M., ... Shard, A. G. (2022). Versailles project on advanced materials and standards (VAMAS) interlaboratory study on measuring the number concentration of colloidal gold nanoparticles. Nanoscale, 14(12), 4690-4704. Article d1nr07775a. Advance online publication. https://doi.org/10.1039/d1nr07775a

@article{c4b262508fd244128a38eb762c2257ea,

title = "Versailles project on advanced materials and standards (VAMAS) interlaboratory study on measuring the number concentration of colloidal gold nanoparticles",

abstract = "We describe the outcome of a large international interlaboratory study of the measurement of particle number concentration of colloidal nanoparticles, project 10 of the technical working area 34, {"}Nanoparticle Populations{"} of the Versailles Project on Advanced Materials and Standards (VAMAS). A total of 50 laboratories delivered results for the number concentration of 30 nm gold colloidal nanoparticles measured using particle tracking analysis (PTA), single particle inductively coupled plasma mass spectrometry (spICP-MS), ultraviolet-visible (UV-Vis) light spectroscopy, centrifugal liquid sedimentation (CLS) and small angle X-ray scattering (SAXS). The study provides quantitative data to evaluate the repeatability of these methods and their reproducibility in the measurement of number concentration of model nanoparticle systems following a common measurement protocol. We find that the population-averaging methods of SAXS, CLS and UV-Vis have high measurement repeatability and reproducibility, with between-labs variability of 2.6%, 11% and 1.4% respectively. However, results may be significantly biased for reasons including inaccurate material properties whose values are used to compute the number concentration. Particle-counting method results are less reproducibile than population-averaging methods, with measured between-labs variability of 68% and 46% for PTA and spICP-MS respectively. This study provides the stakeholder community with important comparative data to underpin measurement reproducibility and method validation for number concentration of nanoparticles.",

author = "Caterina Minelli and Magdalena Wywijas and Dorota Bartczak and Susana Cuello-Nu{\~n}ez and Infante, {Heidi Goenaga} and Jerome Deumer and Christian Gollwitzer and Michael Krumrey and Murphy, {Karen E} and Johnson, {Monique E} and {Montoro Bustos}, {Antonio R} and Strenge, {Ingo H} and Bertrand Faure and Peter H{\o}gh{\o}j and Vivian Tong and Lo{\"i}c Burr and Karin Norling and Fredrik H{\"o}{\"o}k and Matthias Roesslein and Jovana Kocic and Lyndsey Hendriks and Vikram Kestens and Yannic Ramaye and {Contreras Lopez}, {Maria C} and Guy Auclair and Dora Mehn and Douglas Gilliland and Annegret Potthoff and Kathrin Oelschl{\"a}gel and Jutta Tentschert and Harald Jungnickel and Krause, {Benjamin C} and Hachenberger, {Yves U} and Philipp Reichardt and Andreas Luch and Whittaker, {Thomas E} and Stevens, {Molly M} and Shalini Gupta and Akash Singh and Fang-Hsin Lin and Yi-Hung Liu and Costa, {Anna Luisa} and Carlo Baldisserri and Rid Jawad and Andaloussi, {Samir E L} and Holme, {Margaret N} and Lee, {Tae Geol} and Minjeong Kwak and Jaeseok Kim and Johanna Ziebel and Cedric Guignard and Sebastien Cambier and Servane Contal and Gutleb, {Arno C} and {Kuba Tatarkiewicz}, Jan and Jankiewicz, {Bart{\l}omiej J} and Bartosz Bartosewicz and Xiaochun Wu and Fagan, {Jeffrey A} and Elisabeth Elje and Elise Rund{\'e}n-Pran and Maria Dusinska and Kaur, {Inder Preet} and David Price and Ian Nesbitt and {O Reilly}, Sarah and Peters, {Ruud J B} and Guillaume Bucher and Dennis Coleman and Harrison, {Angela J} and Antoine Ghanem and Anne Gering and Eileen McCarron and Niamh Fitzgerald and Geert Cornelis and Jani Tuoriniemi and Midori Sakai and Hidehisa Tsuchida and Ciar{\'a}n Maguire and Adriele Prina-Mello and Lawlor, {Alan J} and Jessica Adams and Schultz, {Carolin L} and Doru Constantin and Thanh, {Nguyen Thi Kim} and Tung, {Le Duc} and Luca Panariello and Spyridon Damilos and Asterios Gavriilidis and Iseult Lynch and Benjamin Fryer and {Carrazco Quevedo}, Ana and Emily Guggenheim and Sophie Briffa and Eugenia Valsami-Jones and Yuxiong Huang and Keller, {Arturo A} and Virva-Tuuli Kinnunen and Siiri Per{\"a}m{\"a}ki and Zeljka Krpetic and Michael Greenwood and Shard, {Alexander G}",

year = "2022",

month = mar,

day = "9",

doi = "10.1039/d1nr07775a",

language = "English",

volume = "14",

pages = "4690--4704",

journal = "Nanoscale",

issn = "2040-3364",

publisher = "Royal Society of Chemistry",

number = "12",

}

Minelli, C, Wywijas, M, Bartczak, D, Cuello-Nuñez, S, Infante, HG, Deumer, J, Gollwitzer, C, Krumrey, M, Murphy, KE, Johnson, ME, Montoro Bustos, AR, Strenge, IH, Faure, B, Høghøj, P, Tong, V, Burr, L, Norling, K, Höök, F, Roesslein, M, Kocic, J, Hendriks, L, Kestens, V, Ramaye, Y, Contreras Lopez, MC, Auclair, G, Mehn, D, Gilliland, D, Potthoff, A, Oelschlägel, K, Tentschert, J, Jungnickel, H, Krause, BC, Hachenberger, YU, Reichardt, P, Luch, A, Whittaker, TE, Stevens, MM, Gupta, S, Singh, A, Lin, F-H, Liu, Y-H, Costa, AL, Baldisserri, C, Jawad, R, Andaloussi, SEL, Holme, MN, Lee, TG, Kwak, M, Kim, J, Ziebel, J, Guignard, C, Cambier, S, Contal, S, Gutleb, AC, Kuba Tatarkiewicz, J, Jankiewicz, BJ, Bartosewicz, B, Wu, X, Fagan, JA, Elje, E, Rundén-Pran, E, Dusinska, M, Kaur, IP, Price, D, Nesbitt, I, O Reilly, S, Peters, RJB, Bucher, G, Coleman, D, Harrison, AJ, Ghanem, A, Gering, A, McCarron, E, Fitzgerald, N, Cornelis, G, Tuoriniemi, J, Sakai, M, Tsuchida, H, Maguire, C, Prina-Mello, A, Lawlor, AJ, Adams, J, Schultz, CL, Constantin, D, Thanh, NTK, Tung, LD, Panariello, L, Damilos, S, Gavriilidis, A, Lynch, I, Fryer, B, Carrazco Quevedo, A, Guggenheim, E, Briffa, S, Valsami-Jones, E, Huang, Y, Keller, AA, Kinnunen, V-T, Perämäki, S, Krpetic, Z, Greenwood, M & Shard, AG 2022, 'Versailles project on advanced materials and standards (VAMAS) interlaboratory study on measuring the number concentration of colloidal gold nanoparticles', Nanoscale, vol. 14, no. 12, d1nr07775a, pp. 4690-4704. https://doi.org/10.1039/d1nr07775a

TY - JOUR

T1 - Versailles project on advanced materials and standards (VAMAS) interlaboratory study on measuring the number concentration of colloidal gold nanoparticles

AU - Minelli, Caterina

AU - Wywijas, Magdalena

AU - Bartczak, Dorota

AU - Cuello-Nuñez, Susana

AU - Infante, Heidi Goenaga

AU - Deumer, Jerome

AU - Gollwitzer, Christian

AU - Krumrey, Michael

AU - Murphy, Karen E

AU - Johnson, Monique E

AU - Montoro Bustos, Antonio R

AU - Strenge, Ingo H

AU - Faure, Bertrand

AU - Høghøj, Peter

AU - Tong, Vivian

AU - Burr, Loïc

AU - Norling, Karin

AU - Höök, Fredrik

AU - Roesslein, Matthias

AU - Kocic, Jovana

AU - Hendriks, Lyndsey

AU - Kestens, Vikram

AU - Ramaye, Yannic

AU - Contreras Lopez, Maria C

AU - Auclair, Guy

AU - Mehn, Dora

AU - Gilliland, Douglas

AU - Potthoff, Annegret

AU - Oelschlägel, Kathrin

AU - Tentschert, Jutta

AU - Jungnickel, Harald

AU - Krause, Benjamin C

AU - Hachenberger, Yves U

AU - Reichardt, Philipp

AU - Luch, Andreas

AU - Whittaker, Thomas E

AU - Stevens, Molly M

AU - Gupta, Shalini

AU - Singh, Akash

AU - Lin, Fang-Hsin

AU - Liu, Yi-Hung

AU - Costa, Anna Luisa

AU - Baldisserri, Carlo

AU - Jawad, Rid

AU - Andaloussi, Samir E L

AU - Holme, Margaret N

AU - Lee, Tae Geol

AU - Kwak, Minjeong

AU - Kim, Jaeseok

AU - Ziebel, Johanna

AU - Guignard, Cedric

AU - Cambier, Sebastien

AU - Contal, Servane

AU - Gutleb, Arno C

AU - Kuba Tatarkiewicz, Jan

AU - Jankiewicz, Bartłomiej J

AU - Bartosewicz, Bartosz

AU - Wu, Xiaochun

AU - Fagan, Jeffrey A

AU - Elje, Elisabeth

AU - Rundén-Pran, Elise

AU - Dusinska, Maria

AU - Kaur, Inder Preet

AU - Price, David

AU - Nesbitt, Ian

AU - O Reilly, Sarah

AU - Peters, Ruud J B

AU - Bucher, Guillaume

AU - Coleman, Dennis

AU - Harrison, Angela J

AU - Ghanem, Antoine

AU - Gering, Anne

AU - McCarron, Eileen

AU - Fitzgerald, Niamh

AU - Cornelis, Geert

AU - Tuoriniemi, Jani

AU - Sakai, Midori

AU - Tsuchida, Hidehisa

AU - Maguire, Ciarán

AU - Prina-Mello, Adriele

AU - Lawlor, Alan J

AU - Adams, Jessica

AU - Schultz, Carolin L

AU - Constantin, Doru

AU - Thanh, Nguyen Thi Kim

AU - Tung, Le Duc

AU - Panariello, Luca

AU - Damilos, Spyridon

AU - Gavriilidis, Asterios

AU - Lynch, Iseult

AU - Fryer, Benjamin

AU - Carrazco Quevedo, Ana

AU - Guggenheim, Emily

AU - Briffa, Sophie

AU - Valsami-Jones, Eugenia

AU - Huang, Yuxiong

AU - Keller, Arturo A

AU - Kinnunen, Virva-Tuuli

AU - Perämäki, Siiri

AU - Krpetic, Zeljka

AU - Greenwood, Michael

AU - Shard, Alexander G

PY - 2022/3/9

Y1 - 2022/3/9

N2 - We describe the outcome of a large international interlaboratory study of the measurement of particle number concentration of colloidal nanoparticles, project 10 of the technical working area 34, "Nanoparticle Populations" of the Versailles Project on Advanced Materials and Standards (VAMAS). A total of 50 laboratories delivered results for the number concentration of 30 nm gold colloidal nanoparticles measured using particle tracking analysis (PTA), single particle inductively coupled plasma mass spectrometry (spICP-MS), ultraviolet-visible (UV-Vis) light spectroscopy, centrifugal liquid sedimentation (CLS) and small angle X-ray scattering (SAXS). The study provides quantitative data to evaluate the repeatability of these methods and their reproducibility in the measurement of number concentration of model nanoparticle systems following a common measurement protocol. We find that the population-averaging methods of SAXS, CLS and UV-Vis have high measurement repeatability and reproducibility, with between-labs variability of 2.6%, 11% and 1.4% respectively. However, results may be significantly biased for reasons including inaccurate material properties whose values are used to compute the number concentration. Particle-counting method results are less reproducibile than population-averaging methods, with measured between-labs variability of 68% and 46% for PTA and spICP-MS respectively. This study provides the stakeholder community with important comparative data to underpin measurement reproducibility and method validation for number concentration of nanoparticles.

AB - We describe the outcome of a large international interlaboratory study of the measurement of particle number concentration of colloidal nanoparticles, project 10 of the technical working area 34, "Nanoparticle Populations" of the Versailles Project on Advanced Materials and Standards (VAMAS). A total of 50 laboratories delivered results for the number concentration of 30 nm gold colloidal nanoparticles measured using particle tracking analysis (PTA), single particle inductively coupled plasma mass spectrometry (spICP-MS), ultraviolet-visible (UV-Vis) light spectroscopy, centrifugal liquid sedimentation (CLS) and small angle X-ray scattering (SAXS). The study provides quantitative data to evaluate the repeatability of these methods and their reproducibility in the measurement of number concentration of model nanoparticle systems following a common measurement protocol. We find that the population-averaging methods of SAXS, CLS and UV-Vis have high measurement repeatability and reproducibility, with between-labs variability of 2.6%, 11% and 1.4% respectively. However, results may be significantly biased for reasons including inaccurate material properties whose values are used to compute the number concentration. Particle-counting method results are less reproducibile than population-averaging methods, with measured between-labs variability of 68% and 46% for PTA and spICP-MS respectively. This study provides the stakeholder community with important comparative data to underpin measurement reproducibility and method validation for number concentration of nanoparticles.

UR - http://www.scopus.com/inward/record.url?scp=85127027556&partnerID=8YFLogxK

U2 - 10.1039/d1nr07775a

DO - 10.1039/d1nr07775a

M3 - Article

C2 - 35262538

SN - 2040-3364

VL - 14

SP - 4690

EP - 4704

JO - Nanoscale

JF - Nanoscale

IS - 12

M1 - d1nr07775a

ER -

Versailles project on advanced materials and standards (VAMAS) interlaboratory study on measuring the number concentration of colloidal gold nanoparticles

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