TY - JOUR
T1 - Less social deprivation is associated with better health-related quality of life (HRQoL) in asthma and is mediated by less anxiety and better sleep quality
AU - Moitra, Subhabrata
AU - Adan, Ana
AU - Akgun, Metin
AU - Anderson, Augustus
AU - Brickstock, Amanda
AU - Eathorne, Allie
AU - Tabrizi, Ali Farshchi
AU - Haldar, Prasun
AU - Henderson, Linda
AU - Jindal, Aditya
AU - Jindal, Surinder Kumar
AU - Kerget, Bugra
AU - Khadour, Fadi
AU - Melenka, Lyle
AU - Moitra, Saibal
AU - Moitra, Tanusree
AU - Mukherjee, Rahul
AU - Semprini, Alex
AU - Turner, Alice M.
AU - Murgia, Nicola
AU - Ferrara, Giovanni
AU - Lacy, Paige
PY - 2023/4/20
Y1 - 2023/4/20
N2 - Background
Previous studies on health-related quality of life (HRQoL) in asthma have mainly focused on clinical and environmental determinants. Little is known about the role of social determinants on HRQoL in asthma.
Objectives
We aimed to investigate the association between social deprivation and HRQoL in asthma.
Methods
691 adult asthmatics from Canada, India, New Zealand, and the United Kingdom were administered a digital questionnaire containing demographic information, and questions about social and psychological attributes, sleep disturbances, and alcohol abuse. HRQoL was measured using the short-form chronic respiratory disease questionnaire (SF-CRQ). We analyzed the direct and indirect relationships between social deprivation and HRQoL using structural equation models with social deprivation as a latent variable. We tested for mediation via anxiety, depression, sleep disturbances, and alcohol abuse.
Results
We found that less social deprivation (latent variable) was directly associated with better SF-CRQ domain scores such as dyspnea (β: 0.33; 95%CI: 0.07 to 0.58), fatigue (β: 0.39; 95%CI: 0.14 to 0.64), and emotional function (β: 0.37; 95%CI: 0.11 to 0.62), but with worse mastery score (β: -0.29; 95%CI: -0.55 to -0.03); however, those associations varied across participating countries. We also observed that among all individual social deprivation indicators, education, companionship, emotional support, instrumental support, and social isolation were directly associated with HRQoL and the relationship between social deprivation and HRQoL was mediated through anxiety and sleep disturbances.
Conclusions
Our results demonstrated that less social deprivation was directly, and indirectly through less anxiety and better sleep quality, associated with better HRQoL in asthma.
AB - Background
Previous studies on health-related quality of life (HRQoL) in asthma have mainly focused on clinical and environmental determinants. Little is known about the role of social determinants on HRQoL in asthma.
Objectives
We aimed to investigate the association between social deprivation and HRQoL in asthma.
Methods
691 adult asthmatics from Canada, India, New Zealand, and the United Kingdom were administered a digital questionnaire containing demographic information, and questions about social and psychological attributes, sleep disturbances, and alcohol abuse. HRQoL was measured using the short-form chronic respiratory disease questionnaire (SF-CRQ). We analyzed the direct and indirect relationships between social deprivation and HRQoL using structural equation models with social deprivation as a latent variable. We tested for mediation via anxiety, depression, sleep disturbances, and alcohol abuse.
Results
We found that less social deprivation (latent variable) was directly associated with better SF-CRQ domain scores such as dyspnea (β: 0.33; 95%CI: 0.07 to 0.58), fatigue (β: 0.39; 95%CI: 0.14 to 0.64), and emotional function (β: 0.37; 95%CI: 0.11 to 0.62), but with worse mastery score (β: -0.29; 95%CI: -0.55 to -0.03); however, those associations varied across participating countries. We also observed that among all individual social deprivation indicators, education, companionship, emotional support, instrumental support, and social isolation were directly associated with HRQoL and the relationship between social deprivation and HRQoL was mediated through anxiety and sleep disturbances.
Conclusions
Our results demonstrated that less social deprivation was directly, and indirectly through less anxiety and better sleep quality, associated with better HRQoL in asthma.
UR - https://www.journals.elsevier.com/the-journal-of-allergy-and-clinical-immunology-in-practice
U2 - 10.1016/j.jaip.2023.03.052
DO - 10.1016/j.jaip.2023.03.052
M3 - Article
SN - 2213-2198
JO - Journal of Allergy and Clinical Immunology: In Practice
JF - Journal of Allergy and Clinical Immunology: In Practice
ER -