Abstract
Cerebrospinal fluid (CSF) analysis is routinely used in the diagnostic work-up of multiple sclerosis (MS), by detecting CSF-specific oligoclonal bands (OCB). More recently, several studies have reported CSF free light chains (FLC) as an alternative. We show that absolute CSF κFLC concentrations were highly sensitive — more than OCB testing — and specific for clinically isolated syndrome, relapsing remitting and primary progressive MS. Measurement of κFLC alone was sufficient. Our results suggest that CSF κFLC levels measured by nephelometry, if validated in a larger series, are a preferred test to OCB analysis in the diagnostic work-up of patients suspected of having MS.
Original language | English |
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Pages (from-to) | 175-179 |
Number of pages | 5 |
Journal | Journal of Neuroimmunology |
Volume | 276 |
Issue number | 1-2 |
Early online date | 8 Aug 2014 |
DOIs | |
Publication status | Published - 15 Nov 2014 |
Keywords
- Adult
- Aged
- Female
- Humans
- Immunoglobulin kappa-Chains
- Male
- Middle Aged
- Multiple Sclerosis
- Nephelometry and Turbidimetry
- Oligoclonal Bands
- Sensitivity and Specificity
- Young Adult