Projects per year
Abstract
The clinical success of immune checkpoint blockade in some patients has transformed treatment approaches in cancer and offers the hope of durable curative responses. Building from studies of chronic infection, the composition of tumour infiltrating lymphocytes and in particular, the spectrum of exhausted CD8 T cells has now been characterized in detail, profiling the phenotype, function, transcriptional regulation and even the epigenetic changes. However, what remains less clear is how intratumoural immune cells interface with populations in the periphery, both in terms of sustaining the response in cancer, but also in establishing systemic memory responses that can provide long-term protection. Here we will succinctly review the current understanding of the anti-tumour response, consider the tissue microenvironments that support key cellular subsets and the extent to which cellular migration between these sites impacts the response.
Original language | English |
---|---|
Article number | kyad004 |
Journal | Discovery Immunology |
Volume | 2 |
Issue number | 1 |
Early online date | 18 Feb 2023 |
DOIs | |
Publication status | E-pub ahead of print - 18 Feb 2023 |
Keywords
- cancer
- CD8 T cells
- stem-like
- immune checkpoint blockade
- trafficking
Fingerprint
Dive into the research topics of 'Migration of stem-like CD8 T cells between tissue microenvironments underpins successful anti-tumour immune responses'. Together they form a unique fingerprint.Projects
- 1 Finished
-
Revealing anti-tumour T cell recruitment and recirculation in vivo to optimise therapeutic intervention.
1/02/19 → 31/01/22
Project: Research