Sex‐specific aging in animals: perspective and future directions

Anne M. Bronikowski; Richard P. Meisel; Peggy R. Biga; James r. Walters; Judith E. Mank; Erica Larschan; Gerald S. Wilkinson; Nicole Valenzuela; Ashley Mae Conard; João Pedro Magalhães; Jingyue (ellie) Duan; Amy E. Elias; Tony Gamble; Rita m. Graze; Kristin E. Gribble; Jill A. Kreiling; Nicole C. Riddle

doi:10.1111/acel.13542

Sex‐specific aging in animals: perspective and future directions

Anne M. Bronikowski, Richard P. Meisel, Peggy R. Biga, James r. Walters, Judith E. Mank, Erica Larschan, Gerald S. Wilkinson, Nicole Valenzuela, Ashley Mae Conard, João Pedro Magalhães, Jingyue (ellie) Duan, Amy E. Elias, Tony Gamble, Rita m. Graze, Kristin E. Gribble, Jill A. Kreiling, Nicole C. Riddle

Inflammation and Ageing

Research output: Contribution to journal › Review article › peer-review

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Abstract

Sex differences in aging occur in many animal species, and they include sex differences in lifespan, in the onset and progression of age-associated decline, and in physiological and molecular markers of aging. Sex differences in aging vary greatly across the animal kingdom. For example, there are species with longer-lived females, species where males live longer, and species lacking sex differences in lifespan. The underlying causes of sex differences in aging remain mostly unknown. Currently, we do not understand the molecular drivers of sex differences in aging, or whether they are related to the accepted hallmarks or pillars of aging or linked to other well-characterized processes. In particular, understanding the role of sex-determination mechanisms and sex differences in aging is relatively understudied. Here, we take a comparative, interdisciplinary approach to explore various hypotheses about how sex differences in aging arise. We discuss genomic, morphological, and environmental differences between the sexes and how these relate to sex differences in aging. Finally, we present some suggestions for future research in this area and provide recommendations for promising experimental designs.

Original language	English
Article number	e13542
Number of pages	25
Journal	Aging Cell
Volume	21
Issue number	2
Early online date	23 Jan 2022
DOIs	https://doi.org/10.1111/acel.13542
Publication status	Published - Feb 2022

Bibliographical note

Funding Information:
We would like to thank all the participants in the series of workshops focused on “Sex, Aging, Genomics, and Epigenetics” held in October 2020 for their insightful and passionate discussions (I. Sullivan as well as unnamed participants). We also thank our facilitators from KnowInnovation for helping us make these workshops a success despite the unplanned switch to a virtual format. Funding for these workshops was provided by National Science Foundation award number 2021305 (PI: NCR).

Publisher Copyright:
© 2022 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.

Keywords

aging
comparative biology
lifespan
mortality
sex differences

ASJC Scopus subject areas

Ageing
Cell Biology

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BronikowskiA2022SexFinal published version, 1.84 MBLicence: Creative Commons: Attribution (CC BY)

Cite this

Bronikowski, A. M., Meisel, R. P., Biga, P. R., Walters, J., Mank, J. E., Larschan, E., Wilkinson, G. S., Valenzuela, N., Conard, A. M., Magalhães, J. P., Duan, J., Elias, A. E., Gamble, T., Graze, R., Gribble, K. E., Kreiling, J. A., & Riddle, N. C. (2022). Sex‐specific aging in animals: perspective and future directions. Aging Cell, 21(2), Article e13542. https://doi.org/10.1111/acel.13542

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Sex‐specific aging in animals: perspective and future directions

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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