Effects of Different Exercise Types on Chrna7 and Chrfam7a Expression in Healthy Normal Weight and Overweight Type 2 Diabetic Adults

Keryma Chaves Da Silva Mateus; Ivan Luiz Padilha Bonfante; Amanda Veiga Sardeli; Renata Garbellini Duft; Arthur Fernandes Gáspari; Joice Cristina Dos Santos Trombeta; Joseane Morari; Bruno Rodrigues; Márcio Alberto Torsoni; Mara Patrícia Traina Chacon-Mikahil; Licio Augusto Velloso; Cláudia Regina Cavaglieri

doi:10.3390/biomedicines11020565

Effects of Different Exercise Types on Chrna7 and Chrfam7a Expression in Healthy Normal Weight and Overweight Type 2 Diabetic Adults

Keryma Chaves Da Silva Mateus, Ivan Luiz Padilha Bonfante^*, Amanda Veiga Sardeli, Renata Garbellini Duft, Arthur Fernandes Gáspari, Joice Cristina Dos Santos Trombeta, Joseane Morari, Bruno Rodrigues, Márcio Alberto Torsoni, Mara Patrícia Traina Chacon-Mikahil, Licio Augusto Velloso, Cláudia Regina Cavaglieri^*

^*Corresponding author for this work

Inflammation and Ageing

Research output: Contribution to journal › Article › peer-review

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Abstract

Purpose: Considering that the CHRNA7 and CHRFAM7A genes can be modulated by acute or chronic inflammation, and exercise modulates inflammatory responses, the question that arises is whether physical exercise could exert any effect on the expression of these genes. Thus, the aim of this work is to identify the effects of different types of exercises on the expression of the CHRNA7, CHRFAM7A and tumor necrosis factor-α (TNF-α) in leukocytes of healthy normal weight (HNW), and overweight with type 2 diabetes (OT2D) individuals.

Methods: 15 OT2D and 13 HNW participants (men and women, from 40 to 60 years old) performed in a randomized crossover design three exercise sessions: aerobic exercise (AE), resistance exercise (RE) and combined exercise (CE). Blood samples were collected at rest and post-60-min of the exercise sessions. The leukocytes were the analysis of the CHRNA7, CHRFAM7A and (TNF-α) gene expression.

Results: At baseline, OT2D had higher CHRFAM7A and TNF-α expression compared to HNW. No statistical differences were observed between groups for CHRNA7; however, the HNW group presented almost twice as many subjects with the expression of this gene (24% vs. 49%). Post exercise, the CHRFAM7A increased in AE, RE and CE for HNW, and in AE and CE for OT2D. There was no significant difference for TNF-α and CHRNA7 expression between any type of exercise and group.

Conclusions: Our study shows that OT2D individuals presented higher baseline expression of TNF-α and CHRFAM7A, besides evidence of decreased CHRNA7A expression in leukocytes when compared with HNW. On the other hand, acutely physical exercise induces increased CHRFAM7A expression, especially when the aerobic component is present.

Original language	English
Article number	565
Number of pages	14
Journal	Biomedicines
Volume	11
Issue number	2
DOIs	https://doi.org/10.3390/biomedicines11020565
Publication status	Published - 15 Feb 2023

Bibliographical note

Funding:
The Higher Education Personnel Improvement Coordination—Brazil (CAPES), finance code 001—financed the scholarship. The data collection and analysis were financially supported by the São Paulo Research Foundation (FAPESP) (n°: 2016/08751-3).

Keywords

obesity
type 2 diabetes mellitus
CHRNA7
CHRFAM7A
physical exercise

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Mateus, K. C. D. S., Bonfante, I. L. P., Sardeli, A. V., Duft, R. G., Gáspari, A. F., Trombeta, J. C. D. S., Morari, J., Rodrigues, B., Torsoni, M. A., Chacon-Mikahil, M. P. T., Velloso, L. A., & Cavaglieri, C. R. (2023). Effects of Different Exercise Types on Chrna7 and Chrfam7a Expression in Healthy Normal Weight and Overweight Type 2 Diabetic Adults. Biomedicines, 11(2), Article 565. https://doi.org/10.3390/biomedicines11020565

@article{b48489c77a4543149a4f83d9ac592109,

title = "Effects of Different Exercise Types on Chrna7 and Chrfam7a Expression in Healthy Normal Weight and Overweight Type 2 Diabetic Adults",

abstract = "Purpose: Considering that the CHRNA7 and CHRFAM7A genes can be modulated by acute or chronic inflammation, and exercise modulates inflammatory responses, the question that arises is whether physical exercise could exert any effect on the expression of these genes. Thus, the aim of this work is to identify the effects of different types of exercises on the expression of the CHRNA7, CHRFAM7A and tumor necrosis factor-α (TNF-α) in leukocytes of healthy normal weight (HNW), and overweight with type 2 diabetes (OT2D) individuals. Methods: 15 OT2D and 13 HNW participants (men and women, from 40 to 60 years old) performed in a randomized crossover design three exercise sessions: aerobic exercise (AE), resistance exercise (RE) and combined exercise (CE). Blood samples were collected at rest and post-60-min of the exercise sessions. The leukocytes were the analysis of the CHRNA7, CHRFAM7A and (TNF-α) gene expression. Results: At baseline, OT2D had higher CHRFAM7A and TNF-α expression compared to HNW. No statistical differences were observed between groups for CHRNA7; however, the HNW group presented almost twice as many subjects with the expression of this gene (24% vs. 49%). Post exercise, the CHRFAM7A increased in AE, RE and CE for HNW, and in AE and CE for OT2D. There was no significant difference for TNF-α and CHRNA7 expression between any type of exercise and group. Conclusions: Our study shows that OT2D individuals presented higher baseline expression of TNF-α and CHRFAM7A, besides evidence of decreased CHRNA7A expression in leukocytes when compared with HNW. On the other hand, acutely physical exercise induces increased CHRFAM7A expression, especially when the aerobic component is present.",

keywords = "obesity, type 2 diabetes mellitus, CHRNA7, CHRFAM7A, physical exercise",

author = "Mateus, {Keryma Chaves Da Silva} and Bonfante, {Ivan Luiz Padilha} and Sardeli, {Amanda Veiga} and Duft, {Renata Garbellini} and G{\'a}spari, {Arthur Fernandes} and Trombeta, {Joice Cristina Dos Santos} and Joseane Morari and Bruno Rodrigues and Torsoni, {M{\'a}rcio Alberto} and Chacon-Mikahil, {Mara Patr{\'i}cia Traina} and Velloso, {Licio Augusto} and Cavaglieri, {Cl{\'a}udia Regina}",

note = "Funding: The Higher Education Personnel Improvement Coordination—Brazil (CAPES), finance code 001—financed the scholarship. The data collection and analysis were financially supported by the S{\~a}o Paulo Research Foundation (FAPESP) (n°: 2016/08751-3).",

year = "2023",

month = feb,

day = "15",

doi = "10.3390/biomedicines11020565",

language = "English",

volume = "11",

journal = "Biomedicines",

issn = "2227-9059",

publisher = "MDPI",

number = "2",

}

Mateus, KCDS, Bonfante, ILP, Sardeli, AV, Duft, RG, Gáspari, AF, Trombeta, JCDS, Morari, J, Rodrigues, B, Torsoni, MA, Chacon-Mikahil, MPT, Velloso, LA & Cavaglieri, CR 2023, 'Effects of Different Exercise Types on Chrna7 and Chrfam7a Expression in Healthy Normal Weight and Overweight Type 2 Diabetic Adults', Biomedicines, vol. 11, no. 2, 565. https://doi.org/10.3390/biomedicines11020565

TY - JOUR

T1 - Effects of Different Exercise Types on Chrna7 and Chrfam7a Expression in Healthy Normal Weight and Overweight Type 2 Diabetic Adults

AU - Mateus, Keryma Chaves Da Silva

AU - Bonfante, Ivan Luiz Padilha

AU - Sardeli, Amanda Veiga

AU - Duft, Renata Garbellini

AU - Gáspari, Arthur Fernandes

AU - Trombeta, Joice Cristina Dos Santos

AU - Morari, Joseane

AU - Rodrigues, Bruno

AU - Torsoni, Márcio Alberto

AU - Chacon-Mikahil, Mara Patrícia Traina

AU - Velloso, Licio Augusto

AU - Cavaglieri, Cláudia Regina

N1 - Funding: The Higher Education Personnel Improvement Coordination—Brazil (CAPES), finance code 001—financed the scholarship. The data collection and analysis were financially supported by the São Paulo Research Foundation (FAPESP) (n°: 2016/08751-3).

PY - 2023/2/15

Y1 - 2023/2/15

N2 - Purpose: Considering that the CHRNA7 and CHRFAM7A genes can be modulated by acute or chronic inflammation, and exercise modulates inflammatory responses, the question that arises is whether physical exercise could exert any effect on the expression of these genes. Thus, the aim of this work is to identify the effects of different types of exercises on the expression of the CHRNA7, CHRFAM7A and tumor necrosis factor-α (TNF-α) in leukocytes of healthy normal weight (HNW), and overweight with type 2 diabetes (OT2D) individuals. Methods: 15 OT2D and 13 HNW participants (men and women, from 40 to 60 years old) performed in a randomized crossover design three exercise sessions: aerobic exercise (AE), resistance exercise (RE) and combined exercise (CE). Blood samples were collected at rest and post-60-min of the exercise sessions. The leukocytes were the analysis of the CHRNA7, CHRFAM7A and (TNF-α) gene expression. Results: At baseline, OT2D had higher CHRFAM7A and TNF-α expression compared to HNW. No statistical differences were observed between groups for CHRNA7; however, the HNW group presented almost twice as many subjects with the expression of this gene (24% vs. 49%). Post exercise, the CHRFAM7A increased in AE, RE and CE for HNW, and in AE and CE for OT2D. There was no significant difference for TNF-α and CHRNA7 expression between any type of exercise and group. Conclusions: Our study shows that OT2D individuals presented higher baseline expression of TNF-α and CHRFAM7A, besides evidence of decreased CHRNA7A expression in leukocytes when compared with HNW. On the other hand, acutely physical exercise induces increased CHRFAM7A expression, especially when the aerobic component is present.

AB - Purpose: Considering that the CHRNA7 and CHRFAM7A genes can be modulated by acute or chronic inflammation, and exercise modulates inflammatory responses, the question that arises is whether physical exercise could exert any effect on the expression of these genes. Thus, the aim of this work is to identify the effects of different types of exercises on the expression of the CHRNA7, CHRFAM7A and tumor necrosis factor-α (TNF-α) in leukocytes of healthy normal weight (HNW), and overweight with type 2 diabetes (OT2D) individuals. Methods: 15 OT2D and 13 HNW participants (men and women, from 40 to 60 years old) performed in a randomized crossover design three exercise sessions: aerobic exercise (AE), resistance exercise (RE) and combined exercise (CE). Blood samples were collected at rest and post-60-min of the exercise sessions. The leukocytes were the analysis of the CHRNA7, CHRFAM7A and (TNF-α) gene expression. Results: At baseline, OT2D had higher CHRFAM7A and TNF-α expression compared to HNW. No statistical differences were observed between groups for CHRNA7; however, the HNW group presented almost twice as many subjects with the expression of this gene (24% vs. 49%). Post exercise, the CHRFAM7A increased in AE, RE and CE for HNW, and in AE and CE for OT2D. There was no significant difference for TNF-α and CHRNA7 expression between any type of exercise and group. Conclusions: Our study shows that OT2D individuals presented higher baseline expression of TNF-α and CHRFAM7A, besides evidence of decreased CHRNA7A expression in leukocytes when compared with HNW. On the other hand, acutely physical exercise induces increased CHRFAM7A expression, especially when the aerobic component is present.

KW - obesity

KW - type 2 diabetes mellitus

KW - CHRNA7

KW - CHRFAM7A

KW - physical exercise

U2 - 10.3390/biomedicines11020565

DO - 10.3390/biomedicines11020565

M3 - Article

SN - 2227-9059

VL - 11

JO - Biomedicines

JF - Biomedicines

IS - 2

M1 - 565

ER -

Effects of Different Exercise Types on Chrna7 and Chrfam7a Expression in Healthy Normal Weight and Overweight Type 2 Diabetic Adults

Abstract

Bibliographical note

Keywords

UN SDGs

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