Development of the PSYCHS: Positive SYmptoms and Diagnostic Criteria for the CAARMS Harmonized with the SIPS

The Accelerating Medicines Partnership Schizophrenia; Scott W. Woods; Sophie Parker; Melissa J. Kerr; Barbara C. Walsh; S. Andrea Wijtenburg; Nicholas Prunier; Angela R. Nunez; Kate Buccilli; Catalina Mourgues‐Codern; Kali Brummitt; Kyle S. Kinney; Carli Trankler; Julia Szacilo; Beau‐Luke Colton; Munaza Ali; Anastasia Haidar; Tashrif Billah; Kevin Huynh; Uzair Ahmed; Laura L. Adery; Patricia J. Marcy; Kelly Allott; Paul Amminger; Celso Arango; Matthew R. Broome; Kristin S. Cadenhead; Eric Y. H. Chen; Jimmy Choi; Philippe Conus; Barbara A. Cornblatt; Louise Birkedal Glenthøj; Leslie E. Horton; Joseph Kambeitz; Tina Kapur; Matcheri S. Keshavan; Nikolaos Koutsouleris; Kerstin Langbein; Suzie Lavoie; Covadonga Martinez Diaz‐Caneja; Daniel H. Mathalon; Vijay A. Mittal; Merete Nordentoft; Ofer Pasternak; Godfrey D. Pearlson; Pablo A. Gaspar; Jai L. Shah; Stefan Smesny; William S. Stone; Gregory P. Strauss; Jijun Wang; Cheryl M. Corcoran; Diana O. Perkins; Jason Schiffman; Jesus Perez; Daniel Mamah; Lauren M. Ellman; III Albert R. Powers; Michael J. Coleman; Alan Anticevic; Paolo Fusar-Poli; John M. Kane; René S. Kahn; Patrick D. McGorry; Carrie E. Bearden; Martha E. Shenton; Barnaby Nelson; Monica E. Calkins; Larry Hendricks; Sylvain Bouix; Jean Addington; Thomas H. McGlashan; Alison R Yung

doi:10.1111/eip.13457

Development of the PSYCHS: Positive SYmptoms and Diagnostic Criteria for the CAARMS Harmonized with the SIPS

The Accelerating Medicines Partnership Schizophrenia, Scott W. Woods^*, Sophie Parker, Melissa J. Kerr, Barbara C. Walsh, S. Andrea Wijtenburg, Nicholas Prunier, Angela R. Nunez, Kate Buccilli, Catalina Mourgues‐Codern, Kali Brummitt, Kyle S. Kinney, Carli Trankler, Julia Szacilo, Beau‐Luke Colton, Munaza Ali, Anastasia Haidar, Tashrif Billah, Kevin Huynh, Uzair AhmedLaura L. Adery, Patricia J. Marcy, Kelly Allott, Paul Amminger, Celso Arango, Matthew R. Broome, Kristin S. Cadenhead, Eric Y. H. Chen, Jimmy Choi, Philippe Conus, Barbara A. Cornblatt, Louise Birkedal Glenthøj, Leslie E. Horton, Joseph Kambeitz, Tina Kapur, Matcheri S. Keshavan, Nikolaos Koutsouleris, Kerstin Langbein, Suzie Lavoie, Covadonga Martinez Diaz‐Caneja, Daniel H. Mathalon, Vijay A. Mittal, Merete Nordentoft, Ofer Pasternak, Godfrey D. Pearlson, Pablo A. Gaspar, Jai L. Shah, Stefan Smesny, William S. Stone, Gregory P. Strauss, Jijun Wang, Cheryl M. Corcoran, Diana O. Perkins, Jason Schiffman, Jesus Perez, Daniel Mamah, Lauren M. Ellman, III Albert R. Powers, Michael J. Coleman, Alan Anticevic, Paolo Fusar-Poli, John M. Kane, René S. Kahn, Patrick D. McGorry, Carrie E. Bearden, Martha E. Shenton, Barnaby Nelson, Monica E. Calkins, Larry Hendricks, Sylvain Bouix, Jean Addington, Thomas H. McGlashan, Alison R Yung

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Aim: To harmonize two ascertainment and severity rating instruments commonly used for the clinical high risk syndrome for psychosis (CHR‐P): the Structured Interview for Psychosis‐risk Syndromes (SIPS) and the Comprehensive Assessment of At‐Risk Mental States (CAARMS).

Methods: The initial workshop is described in the companion report from Addington et al. After the workshop, lead experts for each instrument continued harmonizing attenuated positive symptoms and criteria for psychosis and CHR‐P through an intensive series of joint videoconferences.

Results: Full harmonization was achieved for attenuated positive symptom ratings and psychosis criteria, and modest harmonization for CHR‐P criteria. The semi‐structured interview, named Positive SYmptoms and Diagnostic Criteria for the CAARMS Harmonized with the SIPS (PSYCHS), generates CHR‐P criteria and severity scores for both CAARMS and SIPS.

Conclusions: Using the PSYCHS for CHR‐P ascertainment, conversion determination, and attenuated positive symptom severity rating will help in comparing findings across studies and in meta‐analyses.

Original language	English
Journal	Early Intervention in Psychiatry
Early online date	28 Aug 2023
DOIs	https://doi.org/10.1111/eip.13457
Publication status	E-pub ahead of print - 28 Aug 2023

Keywords

ascertainment
clinical high risk
early detection
psychometrics
severity rating

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The Accelerating Medicines Partnership Schizophrenia, Woods, S. W., Parker, S., Kerr, M. J., Walsh, B. C., Wijtenburg, S. A., Prunier, N., Nunez, A. R., Buccilli, K., Mourgues‐Codern, C., Brummitt, K., Kinney, K. S., Trankler, C., Szacilo, J., Colton, BL., Ali, M., Haidar, A., Billah, T., Huynh, K., ... Yung, A. R. (2023). Development of the PSYCHS: Positive SYmptoms and Diagnostic Criteria for the CAARMS Harmonized with the SIPS. Early Intervention in Psychiatry. Advance online publication. https://doi.org/10.1111/eip.13457

@article{ab3ba1fa860842018f840737d3e8cd29,

title = "Development of the PSYCHS: Positive SYmptoms and Diagnostic Criteria for the CAARMS Harmonized with the SIPS",

abstract = "Aim: To harmonize two ascertainment and severity rating instruments commonly used for the clinical high risk syndrome for psychosis (CHR‐P): the Structured Interview for Psychosis‐risk Syndromes (SIPS) and the Comprehensive Assessment of At‐Risk Mental States (CAARMS). Methods: The initial workshop is described in the companion report from Addington et al. After the workshop, lead experts for each instrument continued harmonizing attenuated positive symptoms and criteria for psychosis and CHR‐P through an intensive series of joint videoconferences. Results: Full harmonization was achieved for attenuated positive symptom ratings and psychosis criteria, and modest harmonization for CHR‐P criteria. The semi‐structured interview, named Positive SYmptoms and Diagnostic Criteria for the CAARMS Harmonized with the SIPS (PSYCHS), generates CHR‐P criteria and severity scores for both CAARMS and SIPS. Conclusions: Using the PSYCHS for CHR‐P ascertainment, conversion determination, and attenuated positive symptom severity rating will help in comparing findings across studies and in meta‐analyses.",

keywords = "ascertainment, clinical high risk, early detection, psychometrics, severity rating",

author = "{The Accelerating Medicines Partnership Schizophrenia} and Woods, {Scott W.} and Sophie Parker and Kerr, {Melissa J.} and Walsh, {Barbara C.} and Wijtenburg, {S. Andrea} and Nicholas Prunier and Nunez, {Angela R.} and Kate Buccilli and Catalina Mourgues‐Codern and Kali Brummitt and Kinney, {Kyle S.} and Carli Trankler and Julia Szacilo and Beau‐Luke Colton and Munaza Ali and Anastasia Haidar and Tashrif Billah and Kevin Huynh and Uzair Ahmed and Adery, {Laura L.} and Marcy, {Patricia J.} and Kelly Allott and Paul Amminger and Celso Arango and Broome, {Matthew R.} and Cadenhead, {Kristin S.} and Chen, {Eric Y. H.} and Jimmy Choi and Philippe Conus and Cornblatt, {Barbara A.} and Glenth{\o}j, {Louise Birkedal} and Horton, {Leslie E.} and Joseph Kambeitz and Tina Kapur and Keshavan, {Matcheri S.} and Nikolaos Koutsouleris and Kerstin Langbein and Suzie Lavoie and Diaz‐Caneja, {Covadonga Martinez} and Mathalon, {Daniel H.} and Mittal, {Vijay A.} and Merete Nordentoft and Ofer Pasternak and Pearlson, {Godfrey D.} and Gaspar, {Pablo A.} and Shah, {Jai L.} and Stefan Smesny and Stone, {William S.} and Strauss, {Gregory P.} and Jijun Wang and Corcoran, {Cheryl M.} and Perkins, {Diana O.} and Jason Schiffman and Jesus Perez and Daniel Mamah and Ellman, {Lauren M.} and {Albert R. Powers}, III and Coleman, {Michael J.} and Alan Anticevic and Paolo Fusar-Poli and Kane, {John M.} and Kahn, {Ren{\'e} S.} and McGorry, {Patrick D.} and Bearden, {Carrie E.} and Shenton, {Martha E.} and Barnaby Nelson and Calkins, {Monica E.} and Larry Hendricks and Sylvain Bouix and Jean Addington and McGlashan, {Thomas H.} and Yung, {Alison R}",

year = "2023",

month = aug,

day = "28",

doi = "10.1111/eip.13457",

language = "English",

journal = "Early Intervention in Psychiatry",

issn = "1751-7885",

publisher = "Wiley",

}

The Accelerating Medicines Partnership Schizophrenia, Woods, SW, Parker, S, Kerr, MJ, Walsh, BC, Wijtenburg, SA, Prunier, N, Nunez, AR, Buccilli, K, Mourgues‐Codern, C, Brummitt, K, Kinney, KS, Trankler, C, Szacilo, J, Colton, BL, Ali, M, Haidar, A, Billah, T, Huynh, K, Ahmed, U, Adery, LL, Marcy, PJ, Allott, K, Amminger, P, Arango, C, Broome, MR, Cadenhead, KS, Chen, EYH, Choi, J, Conus, P, Cornblatt, BA, Glenthøj, LB, Horton, LE, Kambeitz, J, Kapur, T, Keshavan, MS, Koutsouleris, N, Langbein, K, Lavoie, S, Diaz‐Caneja, CM, Mathalon, DH, Mittal, VA, Nordentoft, M, Pasternak, O, Pearlson, GD, Gaspar, PA, Shah, JL, Smesny, S, Stone, WS, Strauss, GP, Wang, J, Corcoran, CM, Perkins, DO, Schiffman, J, Perez, J, Mamah, D, Ellman, LM, Albert R. Powers, III, Coleman, MJ, Anticevic, A, Fusar-Poli, P, Kane, JM, Kahn, RS, McGorry, PD, Bearden, CE, Shenton, ME, Nelson, B, Calkins, ME, Hendricks, L, Bouix, S, Addington, J, McGlashan, TH & Yung, AR 2023, 'Development of the PSYCHS: Positive SYmptoms and Diagnostic Criteria for the CAARMS Harmonized with the SIPS', Early Intervention in Psychiatry. https://doi.org/10.1111/eip.13457

TY - JOUR

T1 - Development of the PSYCHS: Positive SYmptoms and Diagnostic Criteria for the CAARMS Harmonized with the SIPS

AU - The Accelerating Medicines Partnership Schizophrenia

AU - Woods, Scott W.

AU - Parker, Sophie

AU - Kerr, Melissa J.

AU - Walsh, Barbara C.

AU - Wijtenburg, S. Andrea

AU - Prunier, Nicholas

AU - Nunez, Angela R.

AU - Buccilli, Kate

AU - Mourgues‐Codern, Catalina

AU - Brummitt, Kali

AU - Kinney, Kyle S.

AU - Trankler, Carli

AU - Szacilo, Julia

AU - Colton, Beau‐Luke

AU - Ali, Munaza

AU - Haidar, Anastasia

AU - Billah, Tashrif

AU - Huynh, Kevin

AU - Ahmed, Uzair

AU - Adery, Laura L.

AU - Marcy, Patricia J.

AU - Allott, Kelly

AU - Amminger, Paul

AU - Arango, Celso

AU - Broome, Matthew R.

AU - Cadenhead, Kristin S.

AU - Chen, Eric Y. H.

AU - Choi, Jimmy

AU - Conus, Philippe

AU - Cornblatt, Barbara A.

AU - Glenthøj, Louise Birkedal

AU - Horton, Leslie E.

AU - Kambeitz, Joseph

AU - Kapur, Tina

AU - Keshavan, Matcheri S.

AU - Koutsouleris, Nikolaos

AU - Langbein, Kerstin

AU - Lavoie, Suzie

AU - Diaz‐Caneja, Covadonga Martinez

AU - Mathalon, Daniel H.

AU - Mittal, Vijay A.

AU - Nordentoft, Merete

AU - Pasternak, Ofer

AU - Pearlson, Godfrey D.

AU - Gaspar, Pablo A.

AU - Shah, Jai L.

AU - Smesny, Stefan

AU - Stone, William S.

AU - Strauss, Gregory P.

AU - Wang, Jijun

AU - Corcoran, Cheryl M.

AU - Perkins, Diana O.

AU - Schiffman, Jason

AU - Perez, Jesus

AU - Mamah, Daniel

AU - Ellman, Lauren M.

AU - Albert R. Powers, III

AU - Coleman, Michael J.

AU - Anticevic, Alan

AU - Fusar-Poli, Paolo

AU - Kane, John M.

AU - Kahn, René S.

AU - McGorry, Patrick D.

AU - Bearden, Carrie E.

AU - Shenton, Martha E.

AU - Nelson, Barnaby

AU - Calkins, Monica E.

AU - Hendricks, Larry

AU - Bouix, Sylvain

AU - Addington, Jean

AU - McGlashan, Thomas H.

AU - Yung, Alison R

PY - 2023/8/28

Y1 - 2023/8/28

N2 - Aim: To harmonize two ascertainment and severity rating instruments commonly used for the clinical high risk syndrome for psychosis (CHR‐P): the Structured Interview for Psychosis‐risk Syndromes (SIPS) and the Comprehensive Assessment of At‐Risk Mental States (CAARMS). Methods: The initial workshop is described in the companion report from Addington et al. After the workshop, lead experts for each instrument continued harmonizing attenuated positive symptoms and criteria for psychosis and CHR‐P through an intensive series of joint videoconferences. Results: Full harmonization was achieved for attenuated positive symptom ratings and psychosis criteria, and modest harmonization for CHR‐P criteria. The semi‐structured interview, named Positive SYmptoms and Diagnostic Criteria for the CAARMS Harmonized with the SIPS (PSYCHS), generates CHR‐P criteria and severity scores for both CAARMS and SIPS. Conclusions: Using the PSYCHS for CHR‐P ascertainment, conversion determination, and attenuated positive symptom severity rating will help in comparing findings across studies and in meta‐analyses.

AB - Aim: To harmonize two ascertainment and severity rating instruments commonly used for the clinical high risk syndrome for psychosis (CHR‐P): the Structured Interview for Psychosis‐risk Syndromes (SIPS) and the Comprehensive Assessment of At‐Risk Mental States (CAARMS). Methods: The initial workshop is described in the companion report from Addington et al. After the workshop, lead experts for each instrument continued harmonizing attenuated positive symptoms and criteria for psychosis and CHR‐P through an intensive series of joint videoconferences. Results: Full harmonization was achieved for attenuated positive symptom ratings and psychosis criteria, and modest harmonization for CHR‐P criteria. The semi‐structured interview, named Positive SYmptoms and Diagnostic Criteria for the CAARMS Harmonized with the SIPS (PSYCHS), generates CHR‐P criteria and severity scores for both CAARMS and SIPS. Conclusions: Using the PSYCHS for CHR‐P ascertainment, conversion determination, and attenuated positive symptom severity rating will help in comparing findings across studies and in meta‐analyses.

KW - ascertainment

KW - clinical high risk

KW - early detection

KW - psychometrics

KW - severity rating

U2 - 10.1111/eip.13457

DO - 10.1111/eip.13457

M3 - Article

SN - 1751-7885

JO - Early Intervention in Psychiatry

JF - Early Intervention in Psychiatry

ER -

Development of the PSYCHS: Positive SYmptoms and Diagnostic Criteria for the CAARMS Harmonized with the SIPS

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