Triazole-based, optically-pure metallosupramolecules; highly potent and selective anticancer compounds

Hualong Song; Nicola J. Rogers; Viktor Brabec; Guy J. Clarkson; James P. C. Coverdale; Hana Kostrhunova; Roger M. Phillips; Miles Postings; Samantha L. Shepherd; Peter Scott

doi:10.1039/D0CC02429E

Triazole-based, optically-pure metallosupramolecules; highly potent and selective anticancer compounds

Hualong Song, Nicola J. Rogers, Viktor Brabec, Guy J. Clarkson, James P. C. Coverdale, Hana Kostrhunova, Roger M. Phillips, Miles Postings, Samantha L. Shepherd, Peter Scott

Research output: Contribution to journal › Article › peer-review

Abstract

Functionalised triazole aldehydes are used in the highly selective self-assembly of water compatible, optically pure, low symmetry Fe(II)- and Zn(II)-based metallohelices. Sub-micromolar antiproliferative activity is observed against various cancerous cell lines, accompanied by excellent selectivity versus non-cancerous cells and potential for synergistic combinatorial therapy with cisplatin.

Original language	English
Journal	Chemical Communications
Volume	47
DOIs	https://doi.org/10.1039/D0CC02429E
Publication status	Published - 29 Apr 2020
Externally published	Yes

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10.1039/D0CC02429E

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title = "Triazole-based, optically-pure metallosupramolecules; highly potent and selective anticancer compounds",

abstract = "Functionalised triazole aldehydes are used in the highly selective self-assembly of water compatible, optically pure, low symmetry Fe(II)- and Zn(II)-based metallohelices. Sub-micromolar antiproliferative activity is observed against various cancerous cell lines, accompanied by excellent selectivity versus non-cancerous cells and potential for synergistic combinatorial therapy with cisplatin.",

author = "Hualong Song and Rogers, {Nicola J.} and Viktor Brabec and Clarkson, {Guy J.} and Coverdale, {James P. C.} and Hana Kostrhunova and Phillips, {Roger M.} and Miles Postings and Shepherd, {Samantha L.} and Peter Scott",

year = "2020",

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day = "29",

doi = "10.1039/D0CC02429E",

language = "English",

volume = "47",

journal = "Chemical Communications",

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T1 - Triazole-based, optically-pure metallosupramolecules; highly potent and selective anticancer compounds

AU - Song, Hualong

AU - Rogers, Nicola J.

AU - Brabec, Viktor

AU - Clarkson, Guy J.

AU - Coverdale, James P. C.

AU - Kostrhunova, Hana

AU - Phillips, Roger M.

AU - Postings, Miles

AU - Shepherd, Samantha L.

AU - Scott, Peter

PY - 2020/4/29

Y1 - 2020/4/29

N2 - Functionalised triazole aldehydes are used in the highly selective self-assembly of water compatible, optically pure, low symmetry Fe(II)- and Zn(II)-based metallohelices. Sub-micromolar antiproliferative activity is observed against various cancerous cell lines, accompanied by excellent selectivity versus non-cancerous cells and potential for synergistic combinatorial therapy with cisplatin.

AB - Functionalised triazole aldehydes are used in the highly selective self-assembly of water compatible, optically pure, low symmetry Fe(II)- and Zn(II)-based metallohelices. Sub-micromolar antiproliferative activity is observed against various cancerous cell lines, accompanied by excellent selectivity versus non-cancerous cells and potential for synergistic combinatorial therapy with cisplatin.

UR - https://doi.org/10.1039/D0CC02429E

U2 - 10.1039/D0CC02429E

DO - 10.1039/D0CC02429E

M3 - Article

SN - 1359-7345

VL - 47

JO - Chemical Communications

JF - Chemical Communications

ER -

Triazole-based, optically-pure metallosupramolecules; highly potent and selective anticancer compounds

Abstract

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