Nr4a nuclear receptors: markers and modulators of antigen receptor signaling

David Bending*, Julie Zikherman*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

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Abstract

Nr4a1-3 encode a small family of orphan nuclear hormone receptors with transcriptional activity. Their expression reflects both acute and chronic antigen-receptor signaling in T and B-cells, and they have been implicated in critical aspects of lymphocyte development, tolerance, and function. These include roles in regulatory T-cell (Treg), thymic-negative selection, humoral responses, anergy, and exhaustion. Here, we review recent advances in this field such as functional roles in B-cells, transcriptional targets, and mechanism of action. We highlight recurrent themes, including integration of antigen-receptor signaling with costimulatory input, as well as unanswered questions and translational applications of this work.

Original languageEnglish
Article number102285
Number of pages8
JournalCurrent Opinion in Immunology
Volume81
Early online date9 Feb 2023
DOIs
Publication statusPublished - Apr 2023

Bibliographical note

Copyright © 2023 The Authors. Published by Elsevier Ltd.

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