Male breast cancer after childhood cancer: systematic review and analyses in the PanCareSurFup cohort

Yuehan Wang; Raoul C Reulen; Leontien C M Kremer; Florent de Vathaire; Riccardo Haupt; Lorna Zadravec Zaletel; Francesca Bagnasco; Charlotte Demoor-Goldschmidt; Willem J van Dorp; Nadia Haddy; Lars Hjorth; Zsuzsanna Jakab; Claudia E Kuehni; Päivi M Lähteenmäki; Helena J H van der Pal; Carlotta Sacerdote; Roderick Skinner; Monica Terenziani; Finn Wesenberg; Jeanette F Winther; Flora E van Leeuwen; Mike M Hawkins; Jop C Teepen; Elvira C van Dalen; Cécile M Ronckers

doi:10.1016/j.ejca.2022.01.001

Male breast cancer after childhood cancer: systematic review and analyses in the PanCareSurFup cohort

Yuehan Wang^*, Raoul C Reulen, Leontien C M Kremer, Florent de Vathaire, Riccardo Haupt, Lorna Zadravec Zaletel, Francesca Bagnasco, Charlotte Demoor-Goldschmidt, Willem J van Dorp, Nadia Haddy, Lars Hjorth, Zsuzsanna Jakab, Claudia E Kuehni, Päivi M Lähteenmäki, Helena J H van der Pal, Carlotta Sacerdote, Roderick Skinner, Monica Terenziani, Finn Wesenberg, Jeanette F WintherFlora E van Leeuwen, Mike M Hawkins, Jop C Teepen, Elvira C van Dalen, Cécile M Ronckers

^*Corresponding author for this work

Applied Health Research

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Breast cancer is a well-recognised late adverse effect in female childhood cancer survivors (CCSs), especially after chest radiotherapy; information on subsequent male breast cancer (SMBC) is limited. We summarised the existing evidence on SMBC after childhood cancer in a systematic review and investigated the risk of SMBC among males in a Pan-European cohort.

METHODS: We searched Medline/PubMed for cohort studies and case reports/series that assessed SMBC after childhood cancer (≤21 years). Furthermore, we analysed data on SMBC in the PanCareSurFup cohort, reporting standardised incidence ratios (SIRs), absolute excess risks (AERs), and 5- and 10-year survival rates.

RESULTS: The systematic review included 38 of 7080 potentially eligible articles. Cohort-specific SMBC frequencies were 0-0.40% (31 studies). SMBC occurred after a follow-up ranging from 24.0 to 42.0 years. Nine case reports/series described 11 SMBC cases, occurring 11.0-42.5 years after primary childhood cancer. In the PanCareSurFup cohort (16 SMBC/37,738 males; 0.04%), we observed a 22.3-fold increased risk of SMBC relative to the general male population (95% CI 12.7-36.2; absolute excess risk/100,000 person-years: 2.3, 95% CI 1.3-3.7). The five- and ten-year survival rates after SMBC diagnosis were 60.3% (95% CI 35.6%-85.0%) and 43.0% (95% CI 16.1%-69.9%), respectively. Clear evidence of risk factors did not emerge from these comprehensive efforts.

CONCLUSIONS: Compared to the general population, male CCSs have an elevated risk of developing subsequent breast cancer, although the absolute risk is low. Health care providers should be aware of this rare yet serious late effect; male CCSs with symptoms potentially related to SMBC warrant careful examination.

Original language	English
Pages (from-to)	27-47
Number of pages	21
Journal	European Journal of Cancer
Volume	165
Early online date	21 Feb 2022
DOIs	https://doi.org/10.1016/j.ejca.2022.01.001
Publication status	Published - Apr 2022

Bibliographical note

Keywords

Adult
Breast Neoplasms, Male/epidemiology
Cancer Survivors
Child
Cohort Studies
Female
Humans
Incidence
Male
Neoplasms/complications
Registries
Risk Factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.ejca.2022.01.001Licence: None: All rights reserved

Cite this

Wang, Y., Reulen, R. C., Kremer, L. C. M., de Vathaire, F., Haupt, R., Zadravec Zaletel, L., Bagnasco, F., Demoor-Goldschmidt, C., van Dorp, W. J., Haddy, N., Hjorth, L., Jakab, Z., Kuehni, C. E., Lähteenmäki, P. M., van der Pal, H. J. H., Sacerdote, C., Skinner, R., Terenziani, M., Wesenberg, F., ... Ronckers, C. M. (2022). Male breast cancer after childhood cancer: systematic review and analyses in the PanCareSurFup cohort. European Journal of Cancer, 165, 27-47. https://doi.org/10.1016/j.ejca.2022.01.001

@article{99f2b2cfcc65400c8f61baeae2dfba5a,

title = "Male breast cancer after childhood cancer: systematic review and analyses in the PanCareSurFup cohort",

abstract = "BACKGROUND: Breast cancer is a well-recognised late adverse effect in female childhood cancer survivors (CCSs), especially after chest radiotherapy; information on subsequent male breast cancer (SMBC) is limited. We summarised the existing evidence on SMBC after childhood cancer in a systematic review and investigated the risk of SMBC among males in a Pan-European cohort.METHODS: We searched Medline/PubMed for cohort studies and case reports/series that assessed SMBC after childhood cancer (≤21 years). Furthermore, we analysed data on SMBC in the PanCareSurFup cohort, reporting standardised incidence ratios (SIRs), absolute excess risks (AERs), and 5- and 10-year survival rates.RESULTS: The systematic review included 38 of 7080 potentially eligible articles. Cohort-specific SMBC frequencies were 0-0.40% (31 studies). SMBC occurred after a follow-up ranging from 24.0 to 42.0 years. Nine case reports/series described 11 SMBC cases, occurring 11.0-42.5 years after primary childhood cancer. In the PanCareSurFup cohort (16 SMBC/37,738 males; 0.04%), we observed a 22.3-fold increased risk of SMBC relative to the general male population (95% CI 12.7-36.2; absolute excess risk/100,000 person-years: 2.3, 95% CI 1.3-3.7). The five- and ten-year survival rates after SMBC diagnosis were 60.3% (95% CI 35.6%-85.0%) and 43.0% (95% CI 16.1%-69.9%), respectively. Clear evidence of risk factors did not emerge from these comprehensive efforts.CONCLUSIONS: Compared to the general population, male CCSs have an elevated risk of developing subsequent breast cancer, although the absolute risk is low. Health care providers should be aware of this rare yet serious late effect; male CCSs with symptoms potentially related to SMBC warrant careful examination.",

keywords = "Adult, Breast Neoplasms, Male/epidemiology, Cancer Survivors, Child, Cohort Studies, Female, Humans, Incidence, Male, Neoplasms/complications, Registries, Risk Factors",

author = "Yuehan Wang and Reulen, {Raoul C} and Kremer, {Leontien C M} and {de Vathaire}, Florent and Riccardo Haupt and {Zadravec Zaletel}, Lorna and Francesca Bagnasco and Charlotte Demoor-Goldschmidt and {van Dorp}, {Willem J} and Nadia Haddy and Lars Hjorth and Zsuzsanna Jakab and Kuehni, {Claudia E} and L{\"a}hteenm{\"a}ki, {P{\"a}ivi M} and {van der Pal}, {Helena J H} and Carlotta Sacerdote and Roderick Skinner and Monica Terenziani and Finn Wesenberg and Winther, {Jeanette F} and {van Leeuwen}, {Flora E} and Hawkins, {Mike M} and Teepen, {Jop C} and {van Dalen}, {Elvira C} and Ronckers, {C{\'e}cile M}",

year = "2022",

month = apr,

doi = "10.1016/j.ejca.2022.01.001",

language = "English",

volume = "165",

pages = "27--47",

journal = "European Journal of Cancer",

issn = "0959-8049",

publisher = "Elsevier",

}

Wang, Y, Reulen, RC, Kremer, LCM, de Vathaire, F, Haupt, R, Zadravec Zaletel, L, Bagnasco, F, Demoor-Goldschmidt, C, van Dorp, WJ, Haddy, N, Hjorth, L, Jakab, Z, Kuehni, CE, Lähteenmäki, PM, van der Pal, HJH, Sacerdote, C, Skinner, R, Terenziani, M, Wesenberg, F, Winther, JF, van Leeuwen, FE, Hawkins, MM, Teepen, JC, van Dalen, EC & Ronckers, CM 2022, 'Male breast cancer after childhood cancer: systematic review and analyses in the PanCareSurFup cohort', European Journal of Cancer, vol. 165, pp. 27-47. https://doi.org/10.1016/j.ejca.2022.01.001

TY - JOUR

T1 - Male breast cancer after childhood cancer

T2 - systematic review and analyses in the PanCareSurFup cohort

AU - Wang, Yuehan

AU - Reulen, Raoul C

AU - Kremer, Leontien C M

AU - de Vathaire, Florent

AU - Haupt, Riccardo

AU - Zadravec Zaletel, Lorna

AU - Bagnasco, Francesca

AU - Demoor-Goldschmidt, Charlotte

AU - van Dorp, Willem J

AU - Haddy, Nadia

AU - Hjorth, Lars

AU - Jakab, Zsuzsanna

AU - Kuehni, Claudia E

AU - Lähteenmäki, Päivi M

AU - van der Pal, Helena J H

AU - Sacerdote, Carlotta

AU - Skinner, Roderick

AU - Terenziani, Monica

AU - Wesenberg, Finn

AU - Winther, Jeanette F

AU - van Leeuwen, Flora E

AU - Hawkins, Mike M

AU - Teepen, Jop C

AU - van Dalen, Elvira C

AU - Ronckers, Cécile M

PY - 2022/4

Y1 - 2022/4

N2 - BACKGROUND: Breast cancer is a well-recognised late adverse effect in female childhood cancer survivors (CCSs), especially after chest radiotherapy; information on subsequent male breast cancer (SMBC) is limited. We summarised the existing evidence on SMBC after childhood cancer in a systematic review and investigated the risk of SMBC among males in a Pan-European cohort.METHODS: We searched Medline/PubMed for cohort studies and case reports/series that assessed SMBC after childhood cancer (≤21 years). Furthermore, we analysed data on SMBC in the PanCareSurFup cohort, reporting standardised incidence ratios (SIRs), absolute excess risks (AERs), and 5- and 10-year survival rates.RESULTS: The systematic review included 38 of 7080 potentially eligible articles. Cohort-specific SMBC frequencies were 0-0.40% (31 studies). SMBC occurred after a follow-up ranging from 24.0 to 42.0 years. Nine case reports/series described 11 SMBC cases, occurring 11.0-42.5 years after primary childhood cancer. In the PanCareSurFup cohort (16 SMBC/37,738 males; 0.04%), we observed a 22.3-fold increased risk of SMBC relative to the general male population (95% CI 12.7-36.2; absolute excess risk/100,000 person-years: 2.3, 95% CI 1.3-3.7). The five- and ten-year survival rates after SMBC diagnosis were 60.3% (95% CI 35.6%-85.0%) and 43.0% (95% CI 16.1%-69.9%), respectively. Clear evidence of risk factors did not emerge from these comprehensive efforts.CONCLUSIONS: Compared to the general population, male CCSs have an elevated risk of developing subsequent breast cancer, although the absolute risk is low. Health care providers should be aware of this rare yet serious late effect; male CCSs with symptoms potentially related to SMBC warrant careful examination.

AB - BACKGROUND: Breast cancer is a well-recognised late adverse effect in female childhood cancer survivors (CCSs), especially after chest radiotherapy; information on subsequent male breast cancer (SMBC) is limited. We summarised the existing evidence on SMBC after childhood cancer in a systematic review and investigated the risk of SMBC among males in a Pan-European cohort.METHODS: We searched Medline/PubMed for cohort studies and case reports/series that assessed SMBC after childhood cancer (≤21 years). Furthermore, we analysed data on SMBC in the PanCareSurFup cohort, reporting standardised incidence ratios (SIRs), absolute excess risks (AERs), and 5- and 10-year survival rates.RESULTS: The systematic review included 38 of 7080 potentially eligible articles. Cohort-specific SMBC frequencies were 0-0.40% (31 studies). SMBC occurred after a follow-up ranging from 24.0 to 42.0 years. Nine case reports/series described 11 SMBC cases, occurring 11.0-42.5 years after primary childhood cancer. In the PanCareSurFup cohort (16 SMBC/37,738 males; 0.04%), we observed a 22.3-fold increased risk of SMBC relative to the general male population (95% CI 12.7-36.2; absolute excess risk/100,000 person-years: 2.3, 95% CI 1.3-3.7). The five- and ten-year survival rates after SMBC diagnosis were 60.3% (95% CI 35.6%-85.0%) and 43.0% (95% CI 16.1%-69.9%), respectively. Clear evidence of risk factors did not emerge from these comprehensive efforts.CONCLUSIONS: Compared to the general population, male CCSs have an elevated risk of developing subsequent breast cancer, although the absolute risk is low. Health care providers should be aware of this rare yet serious late effect; male CCSs with symptoms potentially related to SMBC warrant careful examination.

KW - Adult

KW - Breast Neoplasms, Male/epidemiology

KW - Cancer Survivors

KW - Child

KW - Cohort Studies

KW - Female

KW - Humans

KW - Incidence

KW - Male

KW - Neoplasms/complications

KW - Registries

KW - Risk Factors

UR - http://www.scopus.com/inward/record.url?scp=85124964577&partnerID=8YFLogxK

U2 - 10.1016/j.ejca.2022.01.001

DO - 10.1016/j.ejca.2022.01.001

M3 - Article

C2 - 35202973

SN - 0959-8049

VL - 165

SP - 27

EP - 47

JO - European Journal of Cancer

JF - European Journal of Cancer

ER -

Male breast cancer after childhood cancer: systematic review and analyses in the PanCareSurFup cohort

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this