TY - JOUR
T1 - Memory destabilization during reconsolidation – a consequence of homeostatic plasticity?
AU - Espinelli Amorim, Felippe
AU - Chapot, Renata
AU - Moulin, Thiago
AU - Lee, Jonathan
AU - Amaral, Olavo
PY - 2021/10/1
Y1 - 2021/10/1
N2 - Remembering is not a static process: When retrieved, a memory can be destabilized and become prone to modifications. This phenomenon has been demonstrated in a number of brain regions, but the neuronal mechanisms that rule memory destabilization and its boundary conditions remain elusive. Using two distinct computational models that combine Hebbian plasticity and synaptic downscaling, we show that homeostatic plasticity can function as a destabilization mechanism, accounting for behavioral results of protein synthesis inhibition upon reactivation with different re-exposure times. Furthermore, by performing systematic reviews, we identify a series of overlapping molecular mechanisms between memory destabilization and synaptic downscaling, although direct experimental links between both phenomena remain scarce. In light of these results, we propose a theoretical framework where memory destabilization can emerge as an epiphenomenon of homeostatic adaptations prompted by memory retrieval.
AB - Remembering is not a static process: When retrieved, a memory can be destabilized and become prone to modifications. This phenomenon has been demonstrated in a number of brain regions, but the neuronal mechanisms that rule memory destabilization and its boundary conditions remain elusive. Using two distinct computational models that combine Hebbian plasticity and synaptic downscaling, we show that homeostatic plasticity can function as a destabilization mechanism, accounting for behavioral results of protein synthesis inhibition upon reactivation with different re-exposure times. Furthermore, by performing systematic reviews, we identify a series of overlapping molecular mechanisms between memory destabilization and synaptic downscaling, although direct experimental links between both phenomena remain scarce. In light of these results, we propose a theoretical framework where memory destabilization can emerge as an epiphenomenon of homeostatic adaptations prompted by memory retrieval.
UR - http://www.scopus.com/inward/record.url?scp=85116354949&partnerID=8YFLogxK
U2 - 10.1101/lm.053418.121
DO - 10.1101/lm.053418.121
M3 - Article
SN - 1549-5485
VL - 28
SP - 371
EP - 389
JO - Learning & memory
JF - Learning & memory
IS - 10
ER -