TY - JOUR
T1 - MicroRNAs and long non-coding RNAs in adrenocortical carcinoma
AU - Detomas, Mario
AU - Pivonello, Claudia
AU - Pellegrini, Bianca
AU - Landwehr, Laura-sophie
AU - Sbiera, Silviu
AU - Pivonello, Rosario
AU - Ronchi, Cristina L.
AU - Colao, Annamaria
AU - Altieri, Barbara
AU - De Martino, Maria Cristina
PY - 2022/7/18
Y1 - 2022/7/18
N2 - Non-coding RNAs (ncRNAs) are a type of genetic material that do not encode proteins but regulate the gene expression at an epigenetic level, such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). The role played by ncRNAs in many physiological and pathological processes has gained attention during the last few decades, as they might be useful in the diagnosis, treatment and management of several human disorders, including endocrine and oncological diseases. Adrenocortical carcinoma (ACC) is a rare and aggressive endocrine cancer, still characterized by high mortality and morbidity due to both endocrine and oncological complications. Despite the rarity of this disease, recently, the role of ncRNA has been quite extensively evaluated in ACC. In order to better explore the role of the ncRNA in human ACC, this review summarizes the current knowledge on ncRNA dysregulation in ACC and its potential role in the diagnosis, treatment, and management of this tumor.
AB - Non-coding RNAs (ncRNAs) are a type of genetic material that do not encode proteins but regulate the gene expression at an epigenetic level, such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). The role played by ncRNAs in many physiological and pathological processes has gained attention during the last few decades, as they might be useful in the diagnosis, treatment and management of several human disorders, including endocrine and oncological diseases. Adrenocortical carcinoma (ACC) is a rare and aggressive endocrine cancer, still characterized by high mortality and morbidity due to both endocrine and oncological complications. Despite the rarity of this disease, recently, the role of ncRNA has been quite extensively evaluated in ACC. In order to better explore the role of the ncRNA in human ACC, this review summarizes the current knowledge on ncRNA dysregulation in ACC and its potential role in the diagnosis, treatment, and management of this tumor.
KW - ACC
KW - adrenocortical adenoma
KW - adrenocortical tumor
KW - lncRNA
KW - miRNA
KW - prognostic markers
UR - http://www.scopus.com/inward/record.url?scp=85135136259&partnerID=8YFLogxK
U2 - 10.3390/cells11142234
DO - 10.3390/cells11142234
M3 - Review article
SN - 2073-4409
VL - 11
JO - Cells
JF - Cells
IS - 14
M1 - 2234
ER -
