Frailty: Pathophysiology, Theoretical and Operational Definition(s), Impact, Prevalence, Management and Prevention, in an Increasingly Economically Developed and Ageing World

Paul Doody; Janet M. Lord; Carolyn A. Greig; Anna C. Whittaker

doi:10.1159/000528561

Frailty: Pathophysiology, Theoretical and Operational Definition(s), Impact, Prevalence, Management and Prevention, in an Increasingly Economically Developed and Ageing World

Paul Doody^*, Janet M. Lord, Carolyn A. Greig, Anna C. Whittaker^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

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Abstract

The world's population is ageing, and most older adults experience a later life burdened with disease and disability. Frailty is a multidimensional and dynamic condition characterized by declines in reserve and function across multiple physiological systems, such that the ability to cope with every day or acute stressors becomes compromised. It is projected to become one of the most serious public health challenges economically developed societies will face in the coming century. This review provides a comprehensive overview of frailty, exploring its pathophysiology, theoretical and operational definition(s), impact, prevalence, management, and prevention, within the context of its emergence as a major public health challenge, in an increasingly economically developed and ageing world. Further, this review discusses the major limitations, deficiencies, and knowledge gaps presently within the field, and future research directions pertinent to the advancement of frailty research and the promotion of healthy longevity among the increasing global population of older adults.

Original language	English
Pages (from-to)	927-945
Number of pages	19
Journal	Gerontology
Volume	69
Issue number	8
DOIs	https://doi.org/10.1159/000528561
Publication status	Published - 1 Aug 2023

Bibliographical note

Funding Information:
This review was supported by the European Commission Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement (675003); of which Dr. Paul Doody was a Marie Sklodowska-Curie doctoral research fellow; Professor Anna Whittaker, Professor Janet Lord, and Professor Carolyn Greig doctoral supervisors; and Professor Anna Whittaker the grant’s principal investigator. The funding source had no role in the design, conduct, or reporting of the review, or the decision to publish the manuscript.

Publisher Copyright:
© 2022 The Author(s). Published by S. Karger AG, Basel. This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC). Usage and distribution for commercial purposes requires written permission.

Keywords

Ageing
Demography
Exercise
Frailty
Rehabilitation

ASJC Scopus subject areas

Ageing
Geriatrics and Gerontology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1159/000528561Licence: Creative Commons: Attribution-NonCommercial (CC BY-NC)

DoodyP2023FrailityFinal published version, 558 KBLicence: Creative Commons: Attribution-NonCommercial (CC BY-NC)

H2020_ITN_PANINI (CO-ORDINATOR)
Thompson, J., Lord, J., Whittaker, A. & Greig, C.
European Commission, European Commission - Management Costs
1/01/16 → 31/12/19
Project: Research

Cite this

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title = "Frailty: Pathophysiology, Theoretical and Operational Definition(s), Impact, Prevalence, Management and Prevention, in an Increasingly Economically Developed and Ageing World",

abstract = "The world's population is ageing, and most older adults experience a later life burdened with disease and disability. Frailty is a multidimensional and dynamic condition characterized by declines in reserve and function across multiple physiological systems, such that the ability to cope with every day or acute stressors becomes compromised. It is projected to become one of the most serious public health challenges economically developed societies will face in the coming century. This review provides a comprehensive overview of frailty, exploring its pathophysiology, theoretical and operational definition(s), impact, prevalence, management, and prevention, within the context of its emergence as a major public health challenge, in an increasingly economically developed and ageing world. Further, this review discusses the major limitations, deficiencies, and knowledge gaps presently within the field, and future research directions pertinent to the advancement of frailty research and the promotion of healthy longevity among the increasing global population of older adults.",

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Frailty: Pathophysiology, Theoretical and Operational Definition(s), Impact, Prevalence, Management and Prevention, in an Increasingly Economically Developed and Ageing World

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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Projects

H2020_ITN_PANINI (CO-ORDINATOR)

Cite this