Periodontal health, neutrophil activity and cardiovascular health in captive chimpanzees

Devan Raindi; Jacqueline Rees; Josefine Hirschfeld; Helen Wright; Phillipa Dobbs; Sophie Moittie; Kate White; Wilhelm Stahl; Mike Martin; Sharon Redrobe; Francis Hughes; Matyas Liptovszky; Kerstin Baiker; Melissa Grant

doi:10.1016/j.archoralbio.2021.105342

Periodontal health, neutrophil activity and cardiovascular health in captive chimpanzees

Devan Raindi, Jacqueline Rees, Josefine Hirschfeld, Helen Wright, Phillipa Dobbs, Sophie Moittie, Kate White, Wilhelm Stahl, Mike Martin, Sharon Redrobe, Francis Hughes, Matyas Liptovszky, Kerstin Baiker, Melissa Grant

Dentistry

Research output: Contribution to journal › Article › peer-review

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Abstract

Objective
To investigate the association of dental and cardiac disease in a cohort of captive chimpanzees

Design
12 captive chimpanzees underwent periodontal and cardiac examinations under anaesthesia during a relocation to a new enclosure. Blood samples were taken for analysis of circulating markers of cardiac health, nutritional status and isolation of neutrophils for functional assays. They were then observed for three years for signs of heart disease.

Results
Although the chimpanzees displayed large quantities of supragingival plaque, they had low bleeding scores. Peripheral blood neutrophils responded to innate and adaptive immune stimuli. In the follow up period two animals died and post mortem confirmed heart disease. Levels of NT-proBNP were found to be high in chimpanzees that died from heart disease.

Conclusions
Whilst there appeared to be a correlation between probing depth and age, there appeared to be no correlation between dental data and heart data in this cohort.

Original language	English
Article number	105342
Journal	Archives of Oral Biology
Volume	134
Early online date	16 Dec 2021
DOIs	https://doi.org/10.1016/j.archoralbio.2021.105342
Publication status	Published - Feb 2022

Keywords

Cardiac health
Chimpanzee
Periodontitis

ASJC Scopus subject areas

Otorhinolaryngology
Dentistry(all)
Cell Biology

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10.1016/j.archoralbio.2021.105342Licence: None: All rights reserved

RaindiD2021PeriodontalAccepted author manuscript, 929 KBLicence: Creative Commons: Attribution-NonCommercial-NoDerivs (CC BY-NC-ND)

Cite this

Raindi, D., Rees, J., Hirschfeld, J., Wright, H., Dobbs, P., Moittie, S., White, K., Stahl, W., Martin, M., Redrobe, S., Hughes, F., Liptovszky, M., Baiker, K., & Grant, M. (2022). Periodontal health, neutrophil activity and cardiovascular health in captive chimpanzees. Archives of Oral Biology, 134, Article 105342. Advance online publication. https://doi.org/10.1016/j.archoralbio.2021.105342

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abstract = "ObjectiveTo investigate the association of dental and cardiac disease in a cohort of captive chimpanzeesDesign12 captive chimpanzees underwent periodontal and cardiac examinations under anaesthesia during a relocation to a new enclosure. Blood samples were taken for analysis of circulating markers of cardiac health, nutritional status and isolation of neutrophils for functional assays. They were then observed for three years for signs of heart disease.ResultsAlthough the chimpanzees displayed large quantities of supragingival plaque, they had low bleeding scores. Peripheral blood neutrophils responded to innate and adaptive immune stimuli. In the follow up period two animals died and post mortem confirmed heart disease. Levels of NT-proBNP were found to be high in chimpanzees that died from heart disease.ConclusionsWhilst there appeared to be a correlation between probing depth and age, there appeared to be no correlation between dental data and heart data in this cohort.",

keywords = "Cardiac health, Chimpanzee, Periodontitis",

author = "Devan Raindi and Jacqueline Rees and Josefine Hirschfeld and Helen Wright and Phillipa Dobbs and Sophie Moittie and Kate White and Wilhelm Stahl and Mike Martin and Sharon Redrobe and Francis Hughes and Matyas Liptovszky and Kerstin Baiker and Melissa Grant",

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doi = "10.1016/j.archoralbio.2021.105342",

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T1 - Periodontal health, neutrophil activity and cardiovascular health in captive chimpanzees

AU - Raindi, Devan

AU - Rees, Jacqueline

AU - Hirschfeld, Josefine

AU - Wright, Helen

AU - Dobbs, Phillipa

AU - Moittie, Sophie

AU - White, Kate

AU - Stahl, Wilhelm

AU - Martin, Mike

AU - Redrobe, Sharon

AU - Hughes, Francis

AU - Liptovszky, Matyas

AU - Baiker, Kerstin

AU - Grant, Melissa

PY - 2022/2

Y1 - 2022/2

N2 - ObjectiveTo investigate the association of dental and cardiac disease in a cohort of captive chimpanzeesDesign12 captive chimpanzees underwent periodontal and cardiac examinations under anaesthesia during a relocation to a new enclosure. Blood samples were taken for analysis of circulating markers of cardiac health, nutritional status and isolation of neutrophils for functional assays. They were then observed for three years for signs of heart disease.ResultsAlthough the chimpanzees displayed large quantities of supragingival plaque, they had low bleeding scores. Peripheral blood neutrophils responded to innate and adaptive immune stimuli. In the follow up period two animals died and post mortem confirmed heart disease. Levels of NT-proBNP were found to be high in chimpanzees that died from heart disease.ConclusionsWhilst there appeared to be a correlation between probing depth and age, there appeared to be no correlation between dental data and heart data in this cohort.

AB - ObjectiveTo investigate the association of dental and cardiac disease in a cohort of captive chimpanzeesDesign12 captive chimpanzees underwent periodontal and cardiac examinations under anaesthesia during a relocation to a new enclosure. Blood samples were taken for analysis of circulating markers of cardiac health, nutritional status and isolation of neutrophils for functional assays. They were then observed for three years for signs of heart disease.ResultsAlthough the chimpanzees displayed large quantities of supragingival plaque, they had low bleeding scores. Peripheral blood neutrophils responded to innate and adaptive immune stimuli. In the follow up period two animals died and post mortem confirmed heart disease. Levels of NT-proBNP were found to be high in chimpanzees that died from heart disease.ConclusionsWhilst there appeared to be a correlation between probing depth and age, there appeared to be no correlation between dental data and heart data in this cohort.

KW - Cardiac health

KW - Chimpanzee

KW - Periodontitis

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JO - Archives of Oral Biology

JF - Archives of Oral Biology

M1 - 105342

ER -

Periodontal health, neutrophil activity and cardiovascular health in captive chimpanzees

Abstract

Keywords

ASJC Scopus subject areas

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