Abstract
Introduction: Although recently introduced directional deep brain stimulation leads provide control of the stimulation field, programing is time consuming. Here we validate local field potentials recorded from directional contacts as a predictor of the most efficient contacts for stimulation in patients with Parkinson’s disease. Methods: Intraoperative local field potentials were recorded from directional contacts in the subthalamic nucleus of 12 patients and beta activity compared with the results of the clinical contact review performed after 4-7 months. Results: Normalized beta activity was positively correlated with the contact’s clinical efficacy. The two contacts with the highest beta activity included the most efficient stimulation contact in up to 92 % and that with the widest therapeutic window in 74% of cases. Conclusion: Local field potentials predict the most efficient stimulation contacts and may provide a useful tool to expedite the selection of the optimal contact for directional deep brain stimulation.
Original language | English |
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Pages (from-to) | 159–164 |
Number of pages | 15 |
Journal | Movement Disorders |
Volume | 33 |
Issue number | 1 |
Early online date | 18 Nov 2017 |
DOIs | |
Publication status | Published - Jan 2018 |