A walk in the PARC: developing and implementing 21st century chemical risk assessment in Europe

P. Marx-Stoelting; G. Rivière; M. Luijten; K. Aiello-Holden; N. Bandow; K. Baken; A. Cañas; A. Castano; S. Denys; C. Fillol; M. Herzler; I. Iavicoli; S. Karakitsios; J. Klanova; M. Kolossa-Gehring; A. Koutsodimou; J. Lobo Vicente; I. Lynch; S. Namorado; S. Norager; A. Pittman; S. Rotter; D. Sarigiannis; M. J. Silva; J. Theunis; T. Tralau; M. Uhl; J. van Klaveren; L. Wendt-Rasch; E. Westerholm; C. Rousselle; P. Sanders

doi:10.1007/s00204-022-03435-7

A walk in the PARC: developing and implementing 21st century chemical risk assessment in Europe

P. Marx-Stoelting^*, G. Rivière, M. Luijten, K. Aiello-Holden, N. Bandow, K. Baken, A. Cañas, A. Castano, S. Denys, C. Fillol, M. Herzler, I. Iavicoli, S. Karakitsios, J. Klanova, M. Kolossa-Gehring, A. Koutsodimou, J. Lobo Vicente, I. Lynch, S. Namorado, S. NoragerA. Pittman, S. Rotter, D. Sarigiannis, M. J. Silva, J. Theunis, T. Tralau, M. Uhl, J. van Klaveren, L. Wendt-Rasch, E. Westerholm, C. Rousselle, P. Sanders

^*Corresponding author for this work

Research output: Contribution to journal › Letter › peer-review

111 Downloads (Pure)

Abstract

Current approaches for the assessment of environmental and human health risks due to exposure to chemical substances have served their purpose reasonably well. Nevertheless, the systems in place for different uses of chemicals are faced with various challenges, ranging from a growing number of chemicals to changes in the types of chemicals and materials produced. This has triggered global awareness of the need for a paradigm shift, which in turn has led to the publication of new concepts for chemical risk assessment and explorations of how to translate these concepts into pragmatic approaches. As a result, next-generation risk assessment (NGRA) is generally seen as the way forward. However, incorporating new scientific insights and innovative approaches into hazard and exposure assessments in such a way that regulatory needs are adequately met has appeared to be challenging. The European Partnership for the Assessment of Risks from Chemicals (PARC) has been designed to address various challenges associated with innovating chemical risk assessment. Its overall goal is to consolidate and strengthen the European research and innovation capacity for chemical risk assessment to protect human health and the environment. With around 200 participating organisations from all over Europe, including three European agencies, and a total budget of over 400 million euro, PARC is one of the largest projects of its kind. It has a duration of seven years and is coordinated by ANSES, the French Agency for Food, Environmental and Occupational Health & Safety.

Original language	English
Pages (from-to)	893-908
Number of pages	16
Journal	Archives of toxicology
Volume	97
Issue number	3
Early online date	16 Jan 2023
DOIs	https://doi.org/10.1007/s00204-022-03435-7
Publication status	Published - Mar 2023

Bibliographical note

Funding Information:
Open Access funding enabled and organized by Projekt DEAL. The European Partnership for the Assessment of Risks from Chemicals has received funding from the European Union’s Horizon Europe research and innovation programme under Grant Agreement No 101057014. Co-funding for the UK contribution via Innovate UK project ID 1752317 as part of the Horizon Europe Guarantee fund. Views and opinions expressed are, however, those of the author(s) only and do not necessarily reflect those of the European Union or the Health and Digital Executive Agency. Neither the European Union nor the granting authority can be held responsible for them.

Publisher Copyright:
© 2023, The Author(s).

Keywords

Chemicals
Exposure assessment
Hazard characterisation
Human biomonitoring (HBM)
New approach methods (NAM)
Next-generation risk assessment (NGRA)
Safety assessment
Letter to the Editor, News and Views

ASJC Scopus subject areas

Health, Toxicology and Mutagenesis
Toxicology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s00204-022-03435-7Licence: Creative Commons: Attribution (CC BY)

MarxStoeltingP2023walkFinal published version, 869 KBLicence: Creative Commons: Attribution (CC BY)

Cite this

Marx-Stoelting, P., Rivière, G., Luijten, M., Aiello-Holden, K., Bandow, N., Baken, K., Cañas, A., Castano, A., Denys, S., Fillol, C., Herzler, M., Iavicoli, I., Karakitsios, S., Klanova, J., Kolossa-Gehring, M., Koutsodimou, A., Vicente, J. L., Lynch, I., Namorado, S., ... Sanders, P. (2023). A walk in the PARC: developing and implementing 21st century chemical risk assessment in Europe. Archives of toxicology, 97(3), 893-908. https://doi.org/10.1007/s00204-022-03435-7

@article{8ad47af3050245208c7bcf2a53a1f1f4,

title = "A walk in the PARC: developing and implementing 21st century chemical risk assessment in Europe",

abstract = "Current approaches for the assessment of environmental and human health risks due to exposure to chemical substances have served their purpose reasonably well. Nevertheless, the systems in place for different uses of chemicals are faced with various challenges, ranging from a growing number of chemicals to changes in the types of chemicals and materials produced. This has triggered global awareness of the need for a paradigm shift, which in turn has led to the publication of new concepts for chemical risk assessment and explorations of how to translate these concepts into pragmatic approaches. As a result, next-generation risk assessment (NGRA) is generally seen as the way forward. However, incorporating new scientific insights and innovative approaches into hazard and exposure assessments in such a way that regulatory needs are adequately met has appeared to be challenging. The European Partnership for the Assessment of Risks from Chemicals (PARC) has been designed to address various challenges associated with innovating chemical risk assessment. Its overall goal is to consolidate and strengthen the European research and innovation capacity for chemical risk assessment to protect human health and the environment. With around 200 participating organisations from all over Europe, including three European agencies, and a total budget of over 400 million euro, PARC is one of the largest projects of its kind. It has a duration of seven years and is coordinated by ANSES, the French Agency for Food, Environmental and Occupational Health & Safety.",

keywords = "Chemicals, Exposure assessment, Hazard characterisation, Human biomonitoring (HBM), New approach methods (NAM), Next-generation risk assessment (NGRA), Safety assessment, Letter to the Editor, News and Views",

author = "P. Marx-Stoelting and G. Rivi{\`e}re and M. Luijten and K. Aiello-Holden and N. Bandow and K. Baken and A. Ca{\~n}as and A. Castano and S. Denys and C. Fillol and M. Herzler and I. Iavicoli and S. Karakitsios and J. Klanova and M. Kolossa-Gehring and A. Koutsodimou and Vicente, {J. Lobo} and I. Lynch and S. Namorado and S. Norager and A. Pittman and S. Rotter and D. Sarigiannis and Silva, {M. J.} and J. Theunis and T. Tralau and M. Uhl and {van Klaveren}, J. and L. Wendt-Rasch and E. Westerholm and C. Rousselle and P. Sanders",

note = "Funding Information: Open Access funding enabled and organized by Projekt DEAL. The European Partnership for the Assessment of Risks from Chemicals has received funding from the European Union{\textquoteright}s Horizon Europe research and innovation programme under Grant Agreement No 101057014. Co-funding for the UK contribution via Innovate UK project ID 1752317 as part of the Horizon Europe Guarantee fund. Views and opinions expressed are, however, those of the author(s) only and do not necessarily reflect those of the European Union or the Health and Digital Executive Agency. Neither the European Union nor the granting authority can be held responsible for them. Publisher Copyright: {\textcopyright} 2023, The Author(s).",

year = "2023",

month = mar,

doi = "10.1007/s00204-022-03435-7",

language = "English",

volume = "97",

pages = "893--908",

journal = "Archives of toxicology",

issn = "0340-5761",

publisher = "Springer",

number = "3",

}

Marx-Stoelting, P, Rivière, G, Luijten, M, Aiello-Holden, K, Bandow, N, Baken, K, Cañas, A, Castano, A, Denys, S, Fillol, C, Herzler, M, Iavicoli, I, Karakitsios, S, Klanova, J, Kolossa-Gehring, M, Koutsodimou, A, Vicente, JL, Lynch, I, Namorado, S, Norager, S, Pittman, A, Rotter, S, Sarigiannis, D, Silva, MJ, Theunis, J, Tralau, T, Uhl, M, van Klaveren, J, Wendt-Rasch, L, Westerholm, E, Rousselle, C & Sanders, P 2023, 'A walk in the PARC: developing and implementing 21st century chemical risk assessment in Europe', Archives of toxicology, vol. 97, no. 3, pp. 893-908. https://doi.org/10.1007/s00204-022-03435-7

TY - JOUR

T1 - A walk in the PARC

T2 - developing and implementing 21st century chemical risk assessment in Europe

AU - Marx-Stoelting, P.

AU - Rivière, G.

AU - Luijten, M.

AU - Aiello-Holden, K.

AU - Bandow, N.

AU - Baken, K.

AU - Cañas, A.

AU - Castano, A.

AU - Denys, S.

AU - Fillol, C.

AU - Herzler, M.

AU - Iavicoli, I.

AU - Karakitsios, S.

AU - Klanova, J.

AU - Kolossa-Gehring, M.

AU - Koutsodimou, A.

AU - Vicente, J. Lobo

AU - Lynch, I.

AU - Namorado, S.

AU - Norager, S.

AU - Pittman, A.

AU - Rotter, S.

AU - Sarigiannis, D.

AU - Silva, M. J.

AU - Theunis, J.

AU - Tralau, T.

AU - Uhl, M.

AU - van Klaveren, J.

AU - Wendt-Rasch, L.

AU - Westerholm, E.

AU - Rousselle, C.

AU - Sanders, P.

N1 - Funding Information: Open Access funding enabled and organized by Projekt DEAL. The European Partnership for the Assessment of Risks from Chemicals has received funding from the European Union’s Horizon Europe research and innovation programme under Grant Agreement No 101057014. Co-funding for the UK contribution via Innovate UK project ID 1752317 as part of the Horizon Europe Guarantee fund. Views and opinions expressed are, however, those of the author(s) only and do not necessarily reflect those of the European Union or the Health and Digital Executive Agency. Neither the European Union nor the granting authority can be held responsible for them. Publisher Copyright: © 2023, The Author(s).

PY - 2023/3

Y1 - 2023/3

N2 - Current approaches for the assessment of environmental and human health risks due to exposure to chemical substances have served their purpose reasonably well. Nevertheless, the systems in place for different uses of chemicals are faced with various challenges, ranging from a growing number of chemicals to changes in the types of chemicals and materials produced. This has triggered global awareness of the need for a paradigm shift, which in turn has led to the publication of new concepts for chemical risk assessment and explorations of how to translate these concepts into pragmatic approaches. As a result, next-generation risk assessment (NGRA) is generally seen as the way forward. However, incorporating new scientific insights and innovative approaches into hazard and exposure assessments in such a way that regulatory needs are adequately met has appeared to be challenging. The European Partnership for the Assessment of Risks from Chemicals (PARC) has been designed to address various challenges associated with innovating chemical risk assessment. Its overall goal is to consolidate and strengthen the European research and innovation capacity for chemical risk assessment to protect human health and the environment. With around 200 participating organisations from all over Europe, including three European agencies, and a total budget of over 400 million euro, PARC is one of the largest projects of its kind. It has a duration of seven years and is coordinated by ANSES, the French Agency for Food, Environmental and Occupational Health & Safety.

AB - Current approaches for the assessment of environmental and human health risks due to exposure to chemical substances have served their purpose reasonably well. Nevertheless, the systems in place for different uses of chemicals are faced with various challenges, ranging from a growing number of chemicals to changes in the types of chemicals and materials produced. This has triggered global awareness of the need for a paradigm shift, which in turn has led to the publication of new concepts for chemical risk assessment and explorations of how to translate these concepts into pragmatic approaches. As a result, next-generation risk assessment (NGRA) is generally seen as the way forward. However, incorporating new scientific insights and innovative approaches into hazard and exposure assessments in such a way that regulatory needs are adequately met has appeared to be challenging. The European Partnership for the Assessment of Risks from Chemicals (PARC) has been designed to address various challenges associated with innovating chemical risk assessment. Its overall goal is to consolidate and strengthen the European research and innovation capacity for chemical risk assessment to protect human health and the environment. With around 200 participating organisations from all over Europe, including three European agencies, and a total budget of over 400 million euro, PARC is one of the largest projects of its kind. It has a duration of seven years and is coordinated by ANSES, the French Agency for Food, Environmental and Occupational Health & Safety.

KW - Chemicals

KW - Exposure assessment

KW - Hazard characterisation

KW - Human biomonitoring (HBM)

KW - New approach methods (NAM)

KW - Next-generation risk assessment (NGRA)

KW - Safety assessment

KW - Letter to the Editor, News and Views

UR - http://www.scopus.com/inward/record.url?scp=85146242985&partnerID=8YFLogxK

U2 - 10.1007/s00204-022-03435-7

DO - 10.1007/s00204-022-03435-7

M3 - Letter

AN - SCOPUS:85146242985

SN - 0340-5761

VL - 97

SP - 893

EP - 908

JO - Archives of toxicology

JF - Archives of toxicology

IS - 3

ER -

A walk in the PARC: developing and implementing 21st century chemical risk assessment in Europe

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Fingerprint

Cite this