Risk of progression from pre-diabetes to type 2 diabetes in a large UK adult cohort

Michael P Gardner; Jingya Wang; Jonathan M Hazlehurst; Chris Sainsbury; Jacqueline Blissett; Krishnarajah Nirantharakumar; Neil Thomas; Srikanth Bellary

doi:10.1111/dme.14996

Risk of progression from pre-diabetes to type 2 diabetes in a large UK adult cohort

Michael P Gardner, Jingya Wang, Jonathan M Hazlehurst, Chris Sainsbury, Jacqueline Blissett, Krishnarajah Nirantharakumar^*, Neil Thomas^*, Srikanth Bellary

^*Corresponding author for this work

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Abstract

Aims: People with pre‐diabetes are at high risk of progressing to type 2 diabetes. This progression is not well characterised by ethnicity, deprivation and age, which we describe in a large cohort of individuals with pre‐diabetes. Methods: A retrospective cohort study with The Health Improvement Network (THIN) database was conducted. Patients aged 18 years and over and diagnosed with pre‐diabetes [HbA1c 42 mmol/mol (6.0%) to 48 mmol/mol (6.5%) were included]. Cox proportional hazards regression was used to calculate adjusted hazard rate ratios (aHR) for the risk of progression from pre‐diabetes to type 2 diabetes for each of the exposure categories [ethnicity, deprivation (Townsend), age and body mass index (BMI)] separately. Results: Of the baseline population with pre‐diabetes (n = 397,853), South Asian (aHR 1.31; 95% CI 1.26–1.37) or Mixed‐Race individuals (aHR 1.22; 95% CI 1.11–1.33) had an increased risk of progression to type 2 diabetes compared with those of white European ethnicity. Likewise, deprivation (aHR 1.17; 95% CI 1.14–1.20; most vs. least deprived) was associated with an increased risk of progression. Both younger (aHR 0.63; 95% CI 0.58–0.69; 18 to

Original language	English
Article number	e14996
Number of pages	10
Journal	Diabetic Medicine
Early online date	29 Oct 2022
DOIs	https://doi.org/10.1111/dme.14996
Publication status	E-pub ahead of print - 29 Oct 2022

Bibliographical note

Keywords

Type 2 diabetes
epidemiology
incidence
pre-diabetes
progression

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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abstract = "Aims: People with pre‐diabetes are at high risk of progressing to type 2 diabetes. This progression is not well characterised by ethnicity, deprivation and age, which we describe in a large cohort of individuals with pre‐diabetes. Methods: A retrospective cohort study with The Health Improvement Network (THIN) database was conducted. Patients aged 18 years and over and diagnosed with pre‐diabetes [HbA1c 42 mmol/mol (6.0%) to 48 mmol/mol (6.5%) were included]. Cox proportional hazards regression was used to calculate adjusted hazard rate ratios (aHR) for the risk of progression from pre‐diabetes to type 2 diabetes for each of the exposure categories [ethnicity, deprivation (Townsend), age and body mass index (BMI)] separately. Results: Of the baseline population with pre‐diabetes (n = 397,853), South Asian (aHR 1.31; 95% CI 1.26–1.37) or Mixed‐Race individuals (aHR 1.22; 95% CI 1.11–1.33) had an increased risk of progression to type 2 diabetes compared with those of white European ethnicity. Likewise, deprivation (aHR 1.17; 95% CI 1.14–1.20; most vs. least deprived) was associated with an increased risk of progression. Both younger (aHR 0.63; 95% CI 0.58–0.69; 18 to",

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AU - Hazlehurst, Jonathan M

AU - Sainsbury, Chris

AU - Blissett, Jacqueline

AU - Nirantharakumar, Krishnarajah

AU - Thomas, Neil

AU - Bellary, Srikanth

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Risk of progression from pre-diabetes to type 2 diabetes in a large UK adult cohort

Abstract

Bibliographical note

Keywords

UN SDGs

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