TY - JOUR
T1 - Exposure to passive heat and cold stress differentially modulates cerebrovascular-CO2 responsiveness
AU - Skinner, Bethany D
AU - Lucas, Rebekah A I
AU - Lucas, Samuel J E
PY - 2023/11/16
Y1 - 2023/11/16
N2 - Heat and cold stress influence cerebral blood flow (CBF) regulatory factors (e.g., arterial CO2 partial pressure). However, it is unclear whether the CBF response to a CO2 stimulus (i.e., cerebrovascular-CO2 responsiveness) is maintained under different thermal conditions. This study aimed to compare cerebrovascular-CO2 responsiveness between normothermia, passive heat and cold stress conditions. Sixteen participants (8 female; 25 ± 7 yrs) completed two experimental sessions (randomised) comprising of normothermic and either passive heat or cold stress conditions. Middle and posterior cerebral artery velocity (MCAv, PCAv) was measured during rest, hypercapnia (5% CO2 inhalation) and hypocapnia (voluntary hyperventilation to an end-tidal CO2 of 30 mmHg). The linear slope of the cerebral blood velocity (CBv) response to changing end-tidal CO2 was calculated to measure cerebrovascular-CO2 responsiveness, and cerebrovascular conductance (CVC) was used to examine responsiveness independent of blood pressure. CBv-CVC-CO2 responsiveness to hypocapnia was greater during heat stress compared to cold stress (MCA: +0.05 ± 0.08 cm/s/mmHg/mmHg, p=0.04; PCA: +0.02 ± 0.02 cm/s/mmHg/mmHg, p=0.002). CBv-CO2 responsiveness to hypercapnia decreased during heat stress (MCA: -0.67 ± 0.89 cm/s/mmHg, p=0.02; PCA: -0.64 ± 0.62 cm/s/mmHg; p=0.01) and increased during cold stress (MCA: +0.98 ± 1.33 cm/s/mmHg, p=0.03; PCA: +1.00 ± 0.82 cm/s/mmHg; p=0.01) compared to normothermia. However, CBv-CVC-CO2 responsiveness to hypercapnia was not different between thermal conditions (p>0.08). Overall, passive heat, but not cold, stress challenges maintenance of cerebral perfusion. A greater cerebrovascular responsiveness to hypocapnia during heat stress likely reduces an already impaired cerebrovascular reserve capacity and may contribute to adverse events (e.g., syncope).
AB - Heat and cold stress influence cerebral blood flow (CBF) regulatory factors (e.g., arterial CO2 partial pressure). However, it is unclear whether the CBF response to a CO2 stimulus (i.e., cerebrovascular-CO2 responsiveness) is maintained under different thermal conditions. This study aimed to compare cerebrovascular-CO2 responsiveness between normothermia, passive heat and cold stress conditions. Sixteen participants (8 female; 25 ± 7 yrs) completed two experimental sessions (randomised) comprising of normothermic and either passive heat or cold stress conditions. Middle and posterior cerebral artery velocity (MCAv, PCAv) was measured during rest, hypercapnia (5% CO2 inhalation) and hypocapnia (voluntary hyperventilation to an end-tidal CO2 of 30 mmHg). The linear slope of the cerebral blood velocity (CBv) response to changing end-tidal CO2 was calculated to measure cerebrovascular-CO2 responsiveness, and cerebrovascular conductance (CVC) was used to examine responsiveness independent of blood pressure. CBv-CVC-CO2 responsiveness to hypocapnia was greater during heat stress compared to cold stress (MCA: +0.05 ± 0.08 cm/s/mmHg/mmHg, p=0.04; PCA: +0.02 ± 0.02 cm/s/mmHg/mmHg, p=0.002). CBv-CO2 responsiveness to hypercapnia decreased during heat stress (MCA: -0.67 ± 0.89 cm/s/mmHg, p=0.02; PCA: -0.64 ± 0.62 cm/s/mmHg; p=0.01) and increased during cold stress (MCA: +0.98 ± 1.33 cm/s/mmHg, p=0.03; PCA: +1.00 ± 0.82 cm/s/mmHg; p=0.01) compared to normothermia. However, CBv-CVC-CO2 responsiveness to hypercapnia was not different between thermal conditions (p>0.08). Overall, passive heat, but not cold, stress challenges maintenance of cerebral perfusion. A greater cerebrovascular responsiveness to hypocapnia during heat stress likely reduces an already impaired cerebrovascular reserve capacity and may contribute to adverse events (e.g., syncope).
U2 - 10.1152/japplphysiol.00494.2023
DO - 10.1152/japplphysiol.00494.2023
M3 - Article
C2 - 37969086
SN - 8750-7587
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
ER -