Abstract
Long-range communication through the motor system is thought to be facilitated by phase coupling between neural activity in the 15-30 Hz beta range. During periods of sustained muscle contraction (grip), such coupling is manifest between motor cortex and the contralateral forearm muscles - measured as the cortico-muscular coherence. We examined alterations in cortico-muscular coherence in individuals with Parkinson's disease, while equating grip strength between individuals with Parkinson's disease (off their medication) and healthy control participants. We show a marked reduction in beta cortico-muscular coherence in the Parkinson's disease group, even though the grip strength was comparable between the two groups. Moreover, the reduced cortico-muscular coherence was related to motor symptoms, so that individuals with lower cortico-muscular coherence also displayed worse motor symptoms. These findings highlight the cortico-muscular coherence as a simple, effective and clinically relevant neural marker of Parkinson's disease pathology, with the potential to aid monitoring of disease progression and the efficacy of novel treatments for Parkinson's disease.
Original language | English |
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Article number | fcab179 |
Journal | Brain Communications |
Volume | 3 |
Issue number | 3 |
DOIs | |
Publication status | Published - 23 Aug 2021 |
Bibliographical note
Publisher Copyright:© 2021 The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain.
Keywords
- cortico-muscular coherence
- magnetoencephalography
- Parkinson's disease
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
- Cellular and Molecular Neuroscience
- Neurology