Stimuli-responsive and core cross-linked micelles developed by NiCCo-PISA of helical poly(aryl isocyanide)s

Setuhn Jimaja, Spyridon Varlas, Jeff Foster, Daniel Taton, Andrew Dove, Rachel O'Reilly

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Abstract

We report the synthesis of redox- and pH-sensitive block copolymer micelles that contain chiral cores composed of helical poly(aryl isocyanide)s. Pentafluorophenyl (PFP) ester-containing micelles synthesised via nickel-catalysed coordination polymerisation-induced self-assembly (NiCCo-PISA) of helical poly(aryl isocyanide) amphiphilic diblock copolymers are modified post-polymerisation with various diamines to introduce cross-links and/or achieve stimulus-sensitive nanostructures. The successful introduction of the diamines is confirmed by Fourier-transform infrared spectroscopy (FT-IR), while the stabilisation effect of the cross-linking is explored by dynamic light scattering (DLS). The retention of the helicity of the core-forming polymer block is verified by circular dichroism (CD) spectroscopy and the stimuli-responsiveness of the nanoparticles towards a reducing agent (L-glutathione, GSH) and pH is evaluated by following the change in the size of the nanoparticles by DLS. These stimuli-responsive nanoparticles could find use in applications such as drug delivery, nanosensors or biological imaging.
Original languageEnglish
Pages (from-to)4047-4053
Number of pages7
JournalPolymer Chemistry
Volume13
Issue number27
Early online date13 Jun 2022
DOIs
Publication statusPublished - 12 Jul 2022

Bibliographical note

Funding Information:
This work was supported by the European Union (SUSPOL-EJD 642671), ERC (grant number 615142), EPSRC, and the University of Birmingham.

Keywords

  • stimuli-responsive
  • micelles
  • diamines

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