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Abstract
Metabolites generated from cellular and tissue metabolism have been rediscovered in recent years as signalling molecules. They may act as cofactor of enzymes or be linked to proteins as post-translational modifiers. They also act as ligands for specific receptors, highlighting that their neglected functions have, in fact, a long standing in evolution. Lactate is one such metabolite that has been considered for long time a waste product of metabolism devoid of any biological function. However, in the past 10 years, lactate has gained much attention in several physio-pathological processes. Mechanisms of sensing and signalling have been discovered and implicated in a broad range of diseases, from cancer to inflammation and fibrosis, providing opportunities for novel therapeutic avenues. Here, we review some of the most recently discovered mechanisms of lactate sensing and signalling.
Original language | English |
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Pages (from-to) | 722-735 |
Number of pages | 14 |
Journal | Trends in Endocrinology & Metabolism |
Volume | 33 |
Issue number | 10 |
Early online date | 20 Aug 2022 |
DOIs | |
Publication status | Published - 1 Oct 2022 |
Bibliographical note
Funding Information:This work is supported by the Medical Research Council (MRC) grant MR/T016736/1 to C.M. and by the European Commission grant H2020-MSCA-IF-2018, 841729 to A.L. Figures were created using Biorender.com .
Publisher Copyright:
© 2022 Elsevier Ltd
Keywords
- acidity
- G protein-coupled receptor
- lactylation
- metabolic reprogramming
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
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