Coprecipitation of curcumin/PVP with enhanced dissolution properties by the supercritical antisolvent process

Ravenna Lessa Matos*, Tiejun Lu, Valentina Prosapio, Christopher McConville, Gary Leeke, Andrew Ingram

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)
276 Downloads (Pure)

Abstract

The poor solubility of curcumin (CURC) in aqueous media leads to a low bioavailability, which prevents its application in pharmaceutical formulations. In this work, the Supercritical Antisolvent process (SAS) was used to produce coprecipitates of CURC and poly (vinyl pyrrolidone) (PVP) from mixtures of ethanol and acetone. The effects of operating parameters: pressure, temperature, solution concentration, drug/polymer mass ratio and solution flow rate were analysed for a 70–30 (v/v) acetone-ethanol mixture. It was found that the composition of acetone in the solvent mixture is the parameter that affects particle size and curcumin recovery the most. The thermal behaviour, crystallinity, molecular interactions, apparent solubility, release profile of the coprecipitates and possible degradation of curcumin were investigated. The results showed that the SAS process is effective in preparing amorphous formulations of CURC/PVP with an apparent solubility of more than 600 times higher than that of the physical mixture of the raw compounds.
Original languageEnglish
Pages (from-to)48-62
Number of pages15
JournalJournal of CO2 Utilization
Volume30
Early online date19 Jan 2019
DOIs
Publication statusPublished - Mar 2019

Keywords

  • coprecipitation
  • curcumin
  • PVP
  • supercritical antisolvent process
  • dissolution

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Waste Management and Disposal
  • Process Chemistry and Technology

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