Projects per year
Abstract
Germinal centers (GCs) are sites where plasma and memory B cells form to generate high-affinity, Ig class-switched antibodies. Specialized stromal cells called follicular dendritic cells (FDCs) are essential for GC formation. During systemic Salmonella Typhimurium (STm) infection GCs are absent, whereas extensive extrafollicular and switched antibody responses are maintained. The mechanisms that underpin the absence of GC formation are incompletely understood. Here, we demonstrate that STm induces a reversible disruption of niches within the splenic microenvironment, including the T and B cell compartments and the marginal zone. Alongside these effects after infection, mature FDC networks are strikingly absent, whereas immature FDC precursors, including marginal sinus pre-FDCs (MadCAM-1+) and perivascular pre-FDCs (PDGFRβ+) are enriched. As normal FDC networks re-establish, extensive GCs become detectable throughout the spleen. Therefore, the reorganization of FDC networks and the loss of GC responses are key, parallel features of systemic STm infections.
Original language | English |
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Article number | 106310 |
Number of pages | 21 |
Journal | iScience |
Volume | 26 |
Issue number | 4 |
Early online date | 2 Mar 2023 |
DOIs | |
Publication status | Published - 21 Apr 2023 |
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Dive into the research topics of 'Salmonella infection induces the reorganization of follicular dendritic cell networks concomitant with the failure to generate germinal centers'. Together they form a unique fingerprint.Projects
- 2 Finished
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Using Salmonella infections to understand why vaccines are less effective in regions with high burdens of bacterial infections
6/03/20 → 30/04/23
Project: Research Councils
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How does inflammation regulate CLEC-2-mediated thrombosis after infection?
1/02/17 → 31/01/21
Project: Research Councils