TY - JOUR
T1 - Core outcome measurement instruments for use in clinical and research settings for adults with post-COVID-19 condition
T2 - an international Delphi consensus study
AU - Gorst, Sarah L
AU - Seylanova, Nina
AU - Dodd, Susanna R
AU - Harman, Nicola L
AU - O'Hara, Margaret
AU - Terwee, Caroline B
AU - Williamson, Paula R
AU - Needham, Dale M
AU - Munblit, Daniel
AU - Nicholson, Timothy R
AU - PC-COS Study Group
AU - Aiyegbusi, Olalekan L.
AU - Akrami, Athena
AU - Apfelbacher, Christian
AU - Calvert, Melanie
AU - Chen, Jessica
AU - Chernyawskaya, Anastasia
AU - Fallon, Vicky
AU - Haroon, Shamil
AU - Hughes, Sarah E.
AU - Jaure, Allison
AU - Kokorinia, Alisa
AU - Michelen, Melina
AU - Olliaro, Piero
AU - Parr, Callum
AU - Pokrovskaya, Alexandra
AU - Saunders, Nile
AU - Schmitt, Jochen
AU - Shemilt, Ian
AU - Sigfrid, Louise
AU - Simpson, Frances
AU - Sivan, Manoj
AU - Stavropoulous, Charitini
PY - 2023/11/2
Y1 - 2023/11/2
N2 - Post-COVID-19 condition (also known as long COVID) is a new, complex, and poorly understood disorder. A core outcome set (COS) for post-COVID-19 condition in adults has been developed and agreement is now required on the most appropriate measurement instruments for these core outcomes. We conducted an international consensus study involving multidisciplinary experts and people with lived experience of long COVID. The study comprised a literature review to identify measurement instruments for the core outcomes, a three-round online modified Delphi process, and an online consensus meeting to generate a core outcome measurement set (COMS). 594 individuals from 58 countries participated. The number of potential instruments for the 12 core outcomes was reduced from 319 to 19. Consensus was reached for inclusion of the modified Medical Research Council Dyspnoea Scale for respiratory outcomes. Measures for two relevant outcomes from a previously published COS for acute COVID-19 were also included: time until death, for survival, and the Recovery Scale for COVID-19, for recovery. Instruments were suggested for consideration for the remaining nine core outcomes: fatigue or exhaustion, pain, post-exertion symptoms, work or occupational and study changes, and cardiovascular, nervous system, cognitive, mental health, and physical outcomes; however, consensus was not achieved for instruments for these outcomes. The recommended COMS and instruments for consideration provide a foundation for the evaluation of post-COVID-19 condition in adults, which should help to optimise clinical care and accelerate research worldwide. Further assessment of this COMS is warranted as new data emerge on existing and novel measurement instruments.
AB - Post-COVID-19 condition (also known as long COVID) is a new, complex, and poorly understood disorder. A core outcome set (COS) for post-COVID-19 condition in adults has been developed and agreement is now required on the most appropriate measurement instruments for these core outcomes. We conducted an international consensus study involving multidisciplinary experts and people with lived experience of long COVID. The study comprised a literature review to identify measurement instruments for the core outcomes, a three-round online modified Delphi process, and an online consensus meeting to generate a core outcome measurement set (COMS). 594 individuals from 58 countries participated. The number of potential instruments for the 12 core outcomes was reduced from 319 to 19. Consensus was reached for inclusion of the modified Medical Research Council Dyspnoea Scale for respiratory outcomes. Measures for two relevant outcomes from a previously published COS for acute COVID-19 were also included: time until death, for survival, and the Recovery Scale for COVID-19, for recovery. Instruments were suggested for consideration for the remaining nine core outcomes: fatigue or exhaustion, pain, post-exertion symptoms, work or occupational and study changes, and cardiovascular, nervous system, cognitive, mental health, and physical outcomes; however, consensus was not achieved for instruments for these outcomes. The recommended COMS and instruments for consideration provide a foundation for the evaluation of post-COVID-19 condition in adults, which should help to optimise clinical care and accelerate research worldwide. Further assessment of this COMS is warranted as new data emerge on existing and novel measurement instruments.
U2 - 10.1016/S2213-2600(23)00370-3
DO - 10.1016/S2213-2600(23)00370-3
M3 - Article
SN - 2213-2600
JO - The Lancet Respiratory Medicine
JF - The Lancet Respiratory Medicine
ER -