Abstract
The breast cancer type-1 susceptibility protein (BRCA1) contributes to genome integrity through homologous recombinational DNA repair and by protecting stalled replication forks from nucleolytic degradation. We recently discovered that fork protection requires a conformational change of BRCA1 unimportant to homologous recombination repair, indicating separate roles for BRCA1 in these pathways.
Original language | English |
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Article number | e1656500 |
Journal | Molecular and Cellular Oncology |
Volume | 6 |
Issue number | 6 |
Early online date | 11 Sept 2019 |
DOIs | |
Publication status | Published - 2 Nov 2019 |
Keywords
- BRCA1
- BARD1
- PIN1
- fork protection
- isomerization
- RAD51