TY - JOUR
T1 - Multidrug efflux pumps
T2 - structure, function and regulation
AU - Du, Dijun
AU - Wang-Kan, Xuan
AU - Neuberger, Arthur
AU - van Veen, Hendrik W.
AU - Pos, Klaas M.
AU - Piddock, Laura J.V.
AU - Luisi, Ben F.
PY - 2018/7/12
Y1 - 2018/7/12
N2 - Infections arising from multidrug-resistant pathogenic bacteria are spreading rapidly throughout the world and threaten to become untreatable. The origins of resistance are numerous and complex, but one underlying factor is the capacity of bacteria to rapidly export drugs through the intrinsic activity of efflux pumps. In this Review, we describe recent advances that have increased our understanding of the structures and molecular mechanisms of multidrug efflux pumps in bacteria. Clinical and laboratory data indicate that efflux pumps function not only in the drug extrusion process but also in virulence and the adaptive responses that contribute to antimicrobial resistance during infection. The emerging picture of the structure, function and regulation of efflux pumps suggests opportunities for countering their activities.
AB - Infections arising from multidrug-resistant pathogenic bacteria are spreading rapidly throughout the world and threaten to become untreatable. The origins of resistance are numerous and complex, but one underlying factor is the capacity of bacteria to rapidly export drugs through the intrinsic activity of efflux pumps. In this Review, we describe recent advances that have increased our understanding of the structures and molecular mechanisms of multidrug efflux pumps in bacteria. Clinical and laboratory data indicate that efflux pumps function not only in the drug extrusion process but also in virulence and the adaptive responses that contribute to antimicrobial resistance during infection. The emerging picture of the structure, function and regulation of efflux pumps suggests opportunities for countering their activities.
UR - http://www.scopus.com/inward/record.url?scp=85049771675&partnerID=8YFLogxK
U2 - 10.1038/s41579-018-0048-6
DO - 10.1038/s41579-018-0048-6
M3 - Review article
AN - SCOPUS:85049771675
SN - 1740-1526
VL - 16
SP - 523
EP - 539
JO - Nature Reviews Microbiology
JF - Nature Reviews Microbiology
IS - 9
ER -