GPVI and CLEC-2

Elizabeth J. Haining; Phillip L.R. Nicolson; Marie Blanche Onselaer; Natalie S. Poulter; Julie Rayes; Mark R. Thomas; Steve P. Watson

doi:10.1016/B978-0-12-813456-6.00011-4

GPVI and CLEC-2

Elizabeth J. Haining, Phillip L.R. Nicolson, Marie Blanche Onselaer, Natalie S. Poulter, Julie Rayes, Mark R. Thomas, Steve P. Watson

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Citations (Scopus)

Abstract

Glycoprotein (GP) VI and C-type lectin-like receptor 2 (CLEC-2) are important surface receptors expressed on platelets that share a common signaling pathway downstream of a hemi-immunoreceptor tyrosine-based activation motif (hemITAM). This chapter discusses what is known about the structure, ligands, and signaling of both proteins, and the diverse and complex platelet functions that they mediate.

Original language	English
Title of host publication	Platelets
Publisher	Elsevier Masson
Pages	213-226
Number of pages	14
ISBN (Electronic)	9780128134566
DOIs	https://doi.org/10.1016/B978-0-12-813456-6.00011-4
Publication status	Published - 1 Jan 2019

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Inc. All rights reserved.

Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.

Keywords

CLEC-2
Collagen
GPVI
HemITAM
Hemostasis
Inflammation
Lymphangiogenesis
Podoplanin
Thrombosis
Vascular integrity

ASJC Scopus subject areas

General Agricultural and Biological Sciences
General Biochemistry,Genetics and Molecular Biology
General Medicine

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10.1016/B978-0-12-813456-6.00011-4

Cite this

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title = "GPVI and CLEC-2",

abstract = "Glycoprotein (GP) VI and C-type lectin-like receptor 2 (CLEC-2) are important surface receptors expressed on platelets that share a common signaling pathway downstream of a hemi-immunoreceptor tyrosine-based activation motif (hemITAM). This chapter discusses what is known about the structure, ligands, and signaling of both proteins, and the diverse and complex platelet functions that they mediate.",

keywords = "CLEC-2, Collagen, GPVI, HemITAM, Hemostasis, Inflammation, Lymphangiogenesis, Podoplanin, Thrombosis, Vascular integrity",

author = "Haining, {Elizabeth J.} and Nicolson, {Phillip L.R.} and Onselaer, {Marie Blanche} and Poulter, {Natalie S.} and Julie Rayes and Thomas, {Mark R.} and Watson, {Steve P.}",

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T1 - GPVI and CLEC-2

AU - Haining, Elizabeth J.

AU - Nicolson, Phillip L.R.

AU - Onselaer, Marie Blanche

AU - Poulter, Natalie S.

AU - Rayes, Julie

AU - Thomas, Mark R.

AU - Watson, Steve P.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Glycoprotein (GP) VI and C-type lectin-like receptor 2 (CLEC-2) are important surface receptors expressed on platelets that share a common signaling pathway downstream of a hemi-immunoreceptor tyrosine-based activation motif (hemITAM). This chapter discusses what is known about the structure, ligands, and signaling of both proteins, and the diverse and complex platelet functions that they mediate.

AB - Glycoprotein (GP) VI and C-type lectin-like receptor 2 (CLEC-2) are important surface receptors expressed on platelets that share a common signaling pathway downstream of a hemi-immunoreceptor tyrosine-based activation motif (hemITAM). This chapter discusses what is known about the structure, ligands, and signaling of both proteins, and the diverse and complex platelet functions that they mediate.

KW - CLEC-2

KW - Collagen

KW - GPVI

KW - HemITAM

KW - Hemostasis

KW - Inflammation

KW - Lymphangiogenesis

KW - Podoplanin

KW - Thrombosis

KW - Vascular integrity

UR - http://www.scopus.com/inward/record.url?scp=85081921982&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-813456-6.00011-4

DO - 10.1016/B978-0-12-813456-6.00011-4

M3 - Chapter

AN - SCOPUS:85081921982

SP - 213

EP - 226

BT - Platelets

PB - Elsevier Masson

ER -

GPVI and CLEC-2

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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Cite this