Rapid determination of enantiomeric excess via NMR spectroscopy: a research-informed experiment

John S. Fossey; Eric V. Anslyn; William D. G. Brittain; Steven D. Bull; Brette M. Chapin; Cécile S. Le Duff; Tony D. James; Glenn Lees; Stephanie Lim; Jennifer A. C. Lloyd; Charles V. Manville; Daniel T. Payne; Kimberley A. Roper

doi:10.1021/acs.jchemed.6b00355

Rapid determination of enantiomeric excess via NMR spectroscopy: a research-informed experiment

John S. Fossey, Eric V. Anslyn, William D. G. Brittain, Steven D. Bull, Brette M. Chapin, Cécile S. Le Duff, Tony D. James, Glenn Lees, Stephanie Lim, Jennifer A. C. Lloyd, Charles V. Manville, Daniel T. Payne, Kimberley A. Roper

Chemistry

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Abstract

An undergraduate chemistry experiment that draws from primary research is described. The experiment exploits chiral supramolecular assemblies for the determination of enantiomeric excess by 1H NMR spectroscopy. This report describes the delivery of the experiment to a cohort of students, and as a result of feedback from those involved, an optimized protocol is presented. Particular care has been taken to facilitate ready adoption in other institutions by providing comprehensive teaching support materials as well as technical guidance for supporting the experiment.

Original language	English
Pages (from-to)	79-84
Number of pages	5
Journal	Journal of Chemical Education
Volume	94
Issue number	1
Early online date	30 Sept 2016
DOIs	https://doi.org/10.1021/acs.jchemed.6b00355
Publication status	Published - Jan 2017

Keywords

Analytical Chemistry
Chirality/Optical Activity
Hands-On Learning/Manipulatives
Computer-Based Learning

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http://pubs.acs.org/doi/abs/10.1021/acs.jchemed.6b00355Licence: Creative Commons: Attribution (CC BY)

Boronic Acids for Dye Sensitised Solar Cells
Fossey, J.
Engineering & Physical Science Research Council
23/04/12 → 22/04/14
Project: Research

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Fossey, J. S., Anslyn, E. V., Brittain, W. D. G., Bull, S. D., Chapin, B. M., Le Duff, C. S., James, T. D., Lees, G., Lim, S., Lloyd, J. A. C., Manville, C. V., Payne, D. T., & Roper, K. A. (2017). Rapid determination of enantiomeric excess via NMR spectroscopy: a research-informed experiment. Journal of Chemical Education, 94(1), 79-84. https://doi.org/10.1021/acs.jchemed.6b00355

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abstract = "An undergraduate chemistry experiment that draws from primary research is described. The experiment exploits chiral supramolecular assemblies for the determination of enantiomeric excess by 1H NMR spectroscopy. This report describes the delivery of the experiment to a cohort of students, and as a result of feedback from those involved, an optimized protocol is presented. Particular care has been taken to facilitate ready adoption in other institutions by providing comprehensive teaching support materials as well as technical guidance for supporting the experiment.",

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AU - Bull, Steven D.

AU - Chapin, Brette M.

AU - Le Duff, Cécile S.

AU - James, Tony D.

AU - Lees, Glenn

AU - Lim, Stephanie

AU - Lloyd, Jennifer A. C.

AU - Manville, Charles V.

AU - Payne, Daniel T.

AU - Roper, Kimberley A.

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KW - Analytical Chemistry

KW - Chirality/Optical Activity

KW - Hands-On Learning/Manipulatives

KW - Computer-Based Learning

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Rapid determination of enantiomeric excess via NMR spectroscopy: a research-informed experiment

Abstract

Keywords

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Boronic Acids for Dye Sensitised Solar Cells

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