Retinopathy and microalbuminuria are common microvascular complications in cystic fibrosis-related diabetes

Punith Kempegowda; Harbinder Sunsoa; Joht Chandan; Lauren Quinn; Prashant Amrelia; Syed Atta; Sidrah Amir; Yee Teh; Sabba Chaudhry; Annie De Bray; Rifat Rashid; Joanna Whitehouse; Edward Nash; Ateeq Syed

doi:10.1177/2042018820966428

Retinopathy and microalbuminuria are common microvascular complications in cystic fibrosis-related diabetes

Punith Kempegowda, Harbinder Sunsoa, Joht Chandan, Lauren Quinn, Prashant Amrelia, Syed Atta, Sidrah Amir, Yee Teh, Sabba Chaudhry, Annie De Bray, Rifat Rashid, Joanna Whitehouse, Edward Nash, Ateeq Syed

Research output: Contribution to journal › Article › peer-review

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Abstract

Aims:
To study the prevalence of microvascular complications and renal changes associated with cystic fibrosis-related diabetes (CFRD).

Methods:
This retrospective cohort study was conducted at the West Midlands Adult Cystic Fibrosis centre, United Kingdom. Data regarding age, sex, microalbuminuria, retinopathy neuropathy, and biochemical results were collected for all people with CFRD who had an annual review from 1 January 2018 to 31 December 2018 at the centre. Descriptive statistics were analysed using STATAv15.1.

Results:
A total of 189 patients were included, of which 56.6% were male and median age (interquartile range) was 33 (27–39) years; 79.4% (150/189) had their annual review in 2018. Those with a biochemically impaired renal function numbered 7.2% (13/180) and 22.7% (32/141) had microalbuminuria; 17.2% (10/58) had diabetes related retinopathy. No one in our cohort had diabetic ulcers; however, 10.3% (13/126) had absent foot pulses.

Conclusion:
We found a higher prevalence of microalbuminuria compared with retinopathy in a large cohort of cystic fibrosis adults. This study demonstrates the need for regular specialist follow-up to facilitate early identification of such complications and a long-term prospective cohort to understand underlying mechanisms.

Original language	English
Pages (from-to)	1-10
Number of pages	10
Journal	Therapeutic Advances in Endocrinology and Metabolism
Volume	11
Early online date	21 Oct 2020
DOIs	https://doi.org/10.1177/2042018820966428
Publication status	Published - 1 Jan 2021

Bibliographical note

Publisher Copyright:
© The Author(s), 2020.

Keywords

cystic fibrosis
diabetes
microalbuminuria
nephropathy
neuropathy
retinopathy

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

Kempegowda, P., Sunsoa, H., Chandan, J., Quinn, L., Amrelia, P., Atta, S., Amir, S., Teh, Y., Chaudhry, S., De Bray, A., Rashid, R., Whitehouse, J., Nash, E., & Syed, A. (2021). Retinopathy and microalbuminuria are common microvascular complications in cystic fibrosis-related diabetes. Therapeutic Advances in Endocrinology and Metabolism, 11, 1-10. https://doi.org/10.1177/2042018820966428

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title = "Retinopathy and microalbuminuria are common microvascular complications in cystic fibrosis-related diabetes",

abstract = "Aims:To study the prevalence of microvascular complications and renal changes associated with cystic fibrosis-related diabetes (CFRD).Methods:This retrospective cohort study was conducted at the West Midlands Adult Cystic Fibrosis centre, United Kingdom. Data regarding age, sex, microalbuminuria, retinopathy neuropathy, and biochemical results were collected for all people with CFRD who had an annual review from 1 January 2018 to 31 December 2018 at the centre. Descriptive statistics were analysed using STATAv15.1.Results:A total of 189 patients were included, of which 56.6% were male and median age (interquartile range) was 33 (27–39) years; 79.4% (150/189) had their annual review in 2018. Those with a biochemically impaired renal function numbered 7.2% (13/180) and 22.7% (32/141) had microalbuminuria; 17.2% (10/58) had diabetes related retinopathy. No one in our cohort had diabetic ulcers; however, 10.3% (13/126) had absent foot pulses.Conclusion:We found a higher prevalence of microalbuminuria compared with retinopathy in a large cohort of cystic fibrosis adults. This study demonstrates the need for regular specialist follow-up to facilitate early identification of such complications and a long-term prospective cohort to understand underlying mechanisms.",

keywords = "cystic fibrosis, diabetes, microalbuminuria, nephropathy, neuropathy, retinopathy",

author = "Punith Kempegowda and Harbinder Sunsoa and Joht Chandan and Lauren Quinn and Prashant Amrelia and Syed Atta and Sidrah Amir and Yee Teh and Sabba Chaudhry and {De Bray}, Annie and Rifat Rashid and Joanna Whitehouse and Edward Nash and Ateeq Syed",

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year = "2021",

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doi = "10.1177/2042018820966428",

language = "English",

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Kempegowda, P, Sunsoa, H, Chandan, J, Quinn, L, Amrelia, P, Atta, S, Amir, S, Teh, Y, Chaudhry, S, De Bray, A, Rashid, R, Whitehouse, J, Nash, E & Syed, A 2021, 'Retinopathy and microalbuminuria are common microvascular complications in cystic fibrosis-related diabetes', Therapeutic Advances in Endocrinology and Metabolism, vol. 11, pp. 1-10. https://doi.org/10.1177/2042018820966428

TY - JOUR

T1 - Retinopathy and microalbuminuria are common microvascular complications in cystic fibrosis-related diabetes

AU - Kempegowda, Punith

AU - Sunsoa, Harbinder

AU - Chandan, Joht

AU - Quinn, Lauren

AU - Amrelia, Prashant

AU - Atta, Syed

AU - Amir, Sidrah

AU - Teh, Yee

AU - Chaudhry, Sabba

AU - De Bray, Annie

AU - Rashid, Rifat

AU - Whitehouse, Joanna

AU - Nash, Edward

AU - Syed, Ateeq

PY - 2021/1/1

Y1 - 2021/1/1

N2 - Aims:To study the prevalence of microvascular complications and renal changes associated with cystic fibrosis-related diabetes (CFRD).Methods:This retrospective cohort study was conducted at the West Midlands Adult Cystic Fibrosis centre, United Kingdom. Data regarding age, sex, microalbuminuria, retinopathy neuropathy, and biochemical results were collected for all people with CFRD who had an annual review from 1 January 2018 to 31 December 2018 at the centre. Descriptive statistics were analysed using STATAv15.1.Results:A total of 189 patients were included, of which 56.6% were male and median age (interquartile range) was 33 (27–39) years; 79.4% (150/189) had their annual review in 2018. Those with a biochemically impaired renal function numbered 7.2% (13/180) and 22.7% (32/141) had microalbuminuria; 17.2% (10/58) had diabetes related retinopathy. No one in our cohort had diabetic ulcers; however, 10.3% (13/126) had absent foot pulses.Conclusion:We found a higher prevalence of microalbuminuria compared with retinopathy in a large cohort of cystic fibrosis adults. This study demonstrates the need for regular specialist follow-up to facilitate early identification of such complications and a long-term prospective cohort to understand underlying mechanisms.

AB - Aims:To study the prevalence of microvascular complications and renal changes associated with cystic fibrosis-related diabetes (CFRD).Methods:This retrospective cohort study was conducted at the West Midlands Adult Cystic Fibrosis centre, United Kingdom. Data regarding age, sex, microalbuminuria, retinopathy neuropathy, and biochemical results were collected for all people with CFRD who had an annual review from 1 January 2018 to 31 December 2018 at the centre. Descriptive statistics were analysed using STATAv15.1.Results:A total of 189 patients were included, of which 56.6% were male and median age (interquartile range) was 33 (27–39) years; 79.4% (150/189) had their annual review in 2018. Those with a biochemically impaired renal function numbered 7.2% (13/180) and 22.7% (32/141) had microalbuminuria; 17.2% (10/58) had diabetes related retinopathy. No one in our cohort had diabetic ulcers; however, 10.3% (13/126) had absent foot pulses.Conclusion:We found a higher prevalence of microalbuminuria compared with retinopathy in a large cohort of cystic fibrosis adults. This study demonstrates the need for regular specialist follow-up to facilitate early identification of such complications and a long-term prospective cohort to understand underlying mechanisms.

KW - cystic fibrosis

KW - diabetes

KW - microalbuminuria

KW - nephropathy

KW - neuropathy

KW - retinopathy

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U2 - 10.1177/2042018820966428

DO - 10.1177/2042018820966428

M3 - Article

SN - 2042-0188

VL - 11

SP - 1

EP - 10

JO - Therapeutic Advances in Endocrinology and Metabolism

JF - Therapeutic Advances in Endocrinology and Metabolism

ER -

Retinopathy and microalbuminuria are common microvascular complications in cystic fibrosis-related diabetes

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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