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Abstract
Receptor dimerisation and higher order oligomerisation regulates signalling by a wide variety of transmembrane receptors. We discuss how agent-based modelling (ABM) combined with advanced microscopy and structural studies can provide new insights into the regulation of clustering, including spatial considerations, revealing novel targets for therapeutic intervention.
Original language | English |
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Pages (from-to) | 643-646 |
Number of pages | 4 |
Journal | Trends in Pharmacological Sciences |
Volume | 44 |
Issue number | 10 |
Early online date | 26 Jul 2023 |
DOIs | |
Publication status | Published - 14 Sept 2023 |
Keywords
- agent-based modelling
- super-resolution
- single-molecule microscopy
- membrane receptors
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Fibrin at the interface of platelet activation and thrombus stabilisation
1/01/18 → 1/10/24
Project: Research