Abstract
Heteroleptic metal-organic cages, formed through integrative self-assembly of ligand mixtures, are highly attractive as reduced symmetry supramolecular hosts. Ensuring high-fidelity, non-statistical self-assembly, however, presents a significant challenge in molecular engineering due to the inherent difficulty in predicting thermodynamic energy landscapes. In this work, two conceptual strategies are described that circumvent this issue, using ligand design strategies to access structurally sophisticated metal-organic hosts. Using these approaches, it was possible to realise cavity environments described by two inequivalent, unsymmetrical ligand frameworks, representing a significant step forward in the construction of highly anisotropic confined spaces.
| Original language | English |
|---|---|
| Article number | e202212392 |
| Number of pages | 7 |
| Journal | Angewandte Chemie International Edition |
| Volume | 61 |
| Issue number | 44 |
| Early online date | 8 Sept 2022 |
| DOIs | |
| Publication status | Published - 2 Nov 2022 |
Bibliographical note
Funding Information:Dr. Andrew J. P. White (Imperial College London) is thanked for collection and analysis of SCXRD data. The Imperial College Research Fellowship programme is acknowledged for funding. Professor Matthew J. Fuchter is thanked for discussions and access to resources.
Publisher Copyright:
© 2022 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.
Keywords
- Cage
- Heteroleptic
- Low-Symmetry
- Metallosupramolecular
- Self-Assembly
ASJC Scopus subject areas
- Catalysis
- General Chemistry