Antimicrobial bioceramics for biomedical applications

Pietro Riccio; Mohadeseh Zare; Diana Gomes; David Green; Artemis Stamboulis

doi:10.1007/978-981-16-7435-8_5

Antimicrobial bioceramics for biomedical applications

Pietro Riccio, Mohadeseh Zare, Diana Gomes, David Green, Artemis Stamboulis

Metallurgy and Materials

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Bioceramics are ideal for hard tissue repair because they are akin to the bone in mechanical and physical properties. The main application of bioceramics is in orthopedics. Orthopedic implants can fail prematurely, mainly due to bacterial colonization and ongoing biofilm formation on implant surfaces. Antimicrobial peptides (AMPs) are small bioactive proteins with unique physicochemical and structural properties, ubiquitous component of the innate immune system, where they play an essential role in modulating both innate and adaptive immune responses. The chapter reviews the fundamental concepts of the design and synthesis of AMPs to functionalize bioceramic coatings, scaffolds, composites and (nano)particles for short- and long-term antibacterial activity.

Original language	English
Title of host publication	Innovative Bioceramics in Translational Medicine I
Subtitle of host publication	Fundamental Research
Editors	Andy H. Choi, Besim Ben-Nissan
Publisher	Springer
Chapter	5
Pages	159-193
Number of pages	35
Edition	1
ISBN (Electronic)	9789811674358
ISBN (Print)	9789811674341, 9789811674372
DOIs	https://doi.org/10.1007/978-981-16-7435-8_5
Publication status	Published - 18 Dec 2021

Publication series

Name	Springer Series In Biomaterials Science and Engineering
Publisher	Springer
Volume	17
ISSN (Print)	2195-0644
ISSN (Electronic)	2195-0652

Keywords

Antimicrobial peptides
AMPs
Surface functionalization
Bacterial infection
Coatings
Physical adsorption
Biofilm
Antibacterial
Proteins

Access to Document

10.1007/978-981-16-7435-8_5

Cite this

Riccio, P., Zare, M., Gomes, D., Green, D., & Stamboulis, A. (2021). Antimicrobial bioceramics for biomedical applications. In A. H. Choi, & B. Ben-Nissan (Eds.), Innovative Bioceramics in Translational Medicine I: Fundamental Research (1 ed., pp. 159-193). (Springer Series In Biomaterials Science and Engineering; Vol. 17). Springer. https://doi.org/10.1007/978-981-16-7435-8_5

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title = "Antimicrobial bioceramics for biomedical applications",

abstract = "Bioceramics are ideal for hard tissue repair because they are akin to the bone in mechanical and physical properties. The main application of bioceramics is in orthopedics. Orthopedic implants can fail prematurely, mainly due to bacterial colonization and ongoing biofilm formation on implant surfaces. Antimicrobial peptides (AMPs) are small bioactive proteins with unique physicochemical and structural properties, ubiquitous component of the innate immune system, where they play an essential role in modulating both innate and adaptive immune responses. The chapter reviews the fundamental concepts of the design and synthesis of AMPs to functionalize bioceramic coatings, scaffolds, composites and (nano)particles for short- and long-term antibacterial activity.",

keywords = "Antimicrobial peptides, AMPs, Surface functionalization, Bacterial infection, Coatings, Physical adsorption, Biofilm, Antibacterial, Proteins",

author = "Pietro Riccio and Mohadeseh Zare and Diana Gomes and David Green and Artemis Stamboulis",

year = "2021",

month = dec,

day = "18",

doi = "10.1007/978-981-16-7435-8_5",

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series = "Springer Series In Biomaterials Science and Engineering",

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Antimicrobial bioceramics for biomedical applications. / Riccio, Pietro ; Zare, Mohadeseh ; Gomes, Diana et al.
Innovative Bioceramics in Translational Medicine I: Fundamental Research. ed. / Andy H. Choi; Besim Ben-Nissan. 1. ed. Springer, 2021. p. 159-193 (Springer Series In Biomaterials Science and Engineering; Vol. 17).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

TY - CHAP

T1 - Antimicrobial bioceramics for biomedical applications

AU - Riccio, Pietro

AU - Zare, Mohadeseh

AU - Gomes, Diana

AU - Green, David

AU - Stamboulis, Artemis

PY - 2021/12/18

Y1 - 2021/12/18

N2 - Bioceramics are ideal for hard tissue repair because they are akin to the bone in mechanical and physical properties. The main application of bioceramics is in orthopedics. Orthopedic implants can fail prematurely, mainly due to bacterial colonization and ongoing biofilm formation on implant surfaces. Antimicrobial peptides (AMPs) are small bioactive proteins with unique physicochemical and structural properties, ubiquitous component of the innate immune system, where they play an essential role in modulating both innate and adaptive immune responses. The chapter reviews the fundamental concepts of the design and synthesis of AMPs to functionalize bioceramic coatings, scaffolds, composites and (nano)particles for short- and long-term antibacterial activity.

AB - Bioceramics are ideal for hard tissue repair because they are akin to the bone in mechanical and physical properties. The main application of bioceramics is in orthopedics. Orthopedic implants can fail prematurely, mainly due to bacterial colonization and ongoing biofilm formation on implant surfaces. Antimicrobial peptides (AMPs) are small bioactive proteins with unique physicochemical and structural properties, ubiquitous component of the innate immune system, where they play an essential role in modulating both innate and adaptive immune responses. The chapter reviews the fundamental concepts of the design and synthesis of AMPs to functionalize bioceramic coatings, scaffolds, composites and (nano)particles for short- and long-term antibacterial activity.

KW - Antimicrobial peptides

KW - AMPs

KW - Surface functionalization

KW - Bacterial infection

KW - Coatings

KW - Physical adsorption

KW - Biofilm

KW - Antibacterial

KW - Proteins

UR - https://link.springer.com/book/10.1007%2F978-981-16-7435-8

U2 - 10.1007/978-981-16-7435-8_5

DO - 10.1007/978-981-16-7435-8_5

M3 - Chapter

SN - 9789811674341

SN - 9789811674372

T3 - Springer Series In Biomaterials Science and Engineering

SP - 159

EP - 193

BT - Innovative Bioceramics in Translational Medicine I

A2 - Choi, Andy H.

A2 - Ben-Nissan, Besim

PB - Springer

ER -

Antimicrobial bioceramics for biomedical applications

Abstract

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Keywords

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