Systemic Lupus Erythematosus: an update for Ophthalmologists

Efrosini Papagiannuli; Benjamin Rhodes; Graham R. Wallace; Caroline Gordon; Philip I. Murray; Alastair K. Denniston

doi:10.1016/j.survophthal.2015.06.003

Systemic Lupus Erythematosus: an update for Ophthalmologists

Efrosini Papagiannuli, Benjamin Rhodes, Graham R. Wallace, Caroline Gordon, Philip I. Murray, Alastair K. Denniston

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Abstract

Systemic lupus erythematosus (SLE) is a life-threatening multi-system inflammatory condition that may affect almost any part of the eye. We provide an update for the practicing ophthalmologist comprising a systematic review of the recent literature presented in the context of current knowledge of the pathogenesis, diagnosis and treatment of this condition. We review recent advances in the understanding of the influence of genetic and environmental factors on the development of SLE. Recent changes in the diagnostic criteria for SLE are considered. We assess the potential for novel molecular biomarkers to find a clinical application in disease diagnosis and stratification and in the development of therapeutic agents. We discuss limited forms of SLE and their differentiation from other collagen vascular disorders and review recent evidence underlying the use of established and novel therapeutics in this condition, including specific implications regarding monitoring for ocular toxicity associated with antimalarials.

Original language	English
Pages (from-to)	65-82
Journal	Survey Ophthalmol
Volume	61
Issue number	1
Early online date	18 Jul 2015
DOIs	https://doi.org/10.1016/j.survophthal.2015.06.003
Publication status	Published - Jan 2016

Keywords

Systemic Lupus Erythematosus
Keratoconjunctivitis sicca
Sjogren’s syndrome
Lupus Retinopathy

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Papagiannuli_et_al_Systemic_Lupus_Erythematosus_Survey_Opthamology_2015
Eligibility for repository: checked 07/10/2015
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Cite this

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title = "Systemic Lupus Erythematosus: an update for Ophthalmologists",

abstract = "Systemic lupus erythematosus (SLE) is a life-threatening multi-system inflammatory condition that may affect almost any part of the eye. We provide an update for the practicing ophthalmologist comprising a systematic review of the recent literature presented in the context of current knowledge of the pathogenesis, diagnosis and treatment of this condition. We review recent advances in the understanding of the influence of genetic and environmental factors on the development of SLE. Recent changes in the diagnostic criteria for SLE are considered. We assess the potential for novel molecular biomarkers to find a clinical application in disease diagnosis and stratification and in the development of therapeutic agents. We discuss limited forms of SLE and their differentiation from other collagen vascular disorders and review recent evidence underlying the use of established and novel therapeutics in this condition, including specific implications regarding monitoring for ocular toxicity associated with antimalarials.",

keywords = "Systemic Lupus Erythematosus, Keratoconjunctivitis sicca, Sjogren{\textquoteright}s syndrome, Lupus Retinopathy",

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year = "2016",

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AU - Papagiannuli, Efrosini

AU - Rhodes, Benjamin

AU - Wallace, Graham R.

AU - Gordon, Caroline

AU - Murray, Philip I.

AU - Denniston, Alastair K.

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AB - Systemic lupus erythematosus (SLE) is a life-threatening multi-system inflammatory condition that may affect almost any part of the eye. We provide an update for the practicing ophthalmologist comprising a systematic review of the recent literature presented in the context of current knowledge of the pathogenesis, diagnosis and treatment of this condition. We review recent advances in the understanding of the influence of genetic and environmental factors on the development of SLE. Recent changes in the diagnostic criteria for SLE are considered. We assess the potential for novel molecular biomarkers to find a clinical application in disease diagnosis and stratification and in the development of therapeutic agents. We discuss limited forms of SLE and their differentiation from other collagen vascular disorders and review recent evidence underlying the use of established and novel therapeutics in this condition, including specific implications regarding monitoring for ocular toxicity associated with antimalarials.

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KW - Keratoconjunctivitis sicca

KW - Sjogren’s syndrome

KW - Lupus Retinopathy

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DO - 10.1016/j.survophthal.2015.06.003

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JO - Survey Ophthalmol

JF - Survey Ophthalmol

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Systemic Lupus Erythematosus: an update for Ophthalmologists

Abstract

Keywords

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