Unravelling microbial efflux through mathematical modelling

Sara Jabbari

doi:10.1099/mic.0.001264

Unravelling microbial efflux through mathematical modelling

Sara Jabbari^*

^*Corresponding author for this work

Mathematics

Research output: Contribution to journal › Review article › peer-review

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Abstract

Mathematical modelling is a useful tool that is increasingly used in the life sciences to understand and predict the behaviour of biological systems. This review looks at how this interdisciplinary approach has advanced our understanding of microbial efflux, the process by which microbes expel harmful substances. The discussion is largely in the context of antimicrobial resistance, but applications in synthetic biology are also touched upon. The goal of the article is to spark further fruitful collaborations between modellers and experimentalists in the efflux community and beyond.

Original language	English
Article number	001264
Number of pages	7
Journal	Microbiology
Volume	168
Issue number	11
DOIs	https://doi.org/10.1099/mic.0.001264
Publication status	Published - 21 Nov 2022

Keywords

efflux pumps
interdisciplinary
mathematical modelling and multidisciplinary

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10.1099/mic.0.001264Licence: Creative Commons: Attribution (CC BY)

JabbariS2022UnravellingFinal published version, 219 KBLicence: Creative Commons: Attribution (CC BY)

2 Article

Dynamic Boolean modelling reveals the influence of energy supply on bacterial efflux pump expression
Kerr, R., Jabbari, S., Blair, J. & Johnston, I. G., 26 Jan 2022, In: Journal of The Royal Society Interface. 19, 186, 14 p., 20210771.
Research output: Contribution to journal › Article › peer-review

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Mathematical modelling highlights the potential for genetic manipulation as an adjuvant to counter efflux-mediated MDR in salmonella
Youlden, G., McNeil, H. E., Blair, J. M. A., Jabbari, S. & King, J. R., 5 Apr 2022, In: Bulletin of Mathematical Biology. 84, 5, 38 p., 56.
Research output: Contribution to journal › Article › peer-review

Open Access
File
47 Downloads (Pure)

Cite this

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AB - Mathematical modelling is a useful tool that is increasingly used in the life sciences to understand and predict the behaviour of biological systems. This review looks at how this interdisciplinary approach has advanced our understanding of microbial efflux, the process by which microbes expel harmful substances. The discussion is largely in the context of antimicrobial resistance, but applications in synthetic biology are also touched upon. The goal of the article is to spark further fruitful collaborations between modellers and experimentalists in the efflux community and beyond.

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Unravelling microbial efflux through mathematical modelling

Abstract

Keywords

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Research output

Dynamic Boolean modelling reveals the influence of energy supply on bacterial efflux pump expression

Mathematical modelling highlights the potential for genetic manipulation as an adjuvant to counter efflux-mediated MDR in salmonella

Cite this