What fungal CNS infections can teach us about neuroimmunology and CNS-specific immunity

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Abstract

Immunity to fungal infections of the central nervous system (CNS) is one of the most poorly understood subjects within the field of medical mycology. Yet, the majority of deaths from invasive fungal infections are caused by brain-tropic fungi. In recent years, there have been several significant discoveries in the regulation of neuroinflammation and the role of the immune system in tissue homeostasis within the CNS. In this review, I highlight five important advances in the neuroimmunology field over the last decade and discuss how we should capitalise on these discoveries to better understand the pathogenesis of fungal CNS infections. In addition, the latest insights into fungal invasion tactics, microglia-astrocyte crosstalk and regulation of antifungal adaptive immune responses are summarised in the context of our contemporary understanding of CNS-specific immunity.

Original languageEnglish
Article number101751
Number of pages7
JournalSeminars in Immunology
Volume67
Early online date27 Mar 2023
DOIs
Publication statusPublished - 1 May 2023

Bibliographical note

Copyright © 2023 The Authors

Keywords

  • Humans
  • Central Nervous System
  • Microglia
  • Mycoses
  • Immunity
  • Central Nervous System Infections

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