Adaptive T cell tuning in immune regulation and immunotherapy of autoimmune diseases✰

David C Wraith

doi:10.1016/j.imlet.2022.02.007

Adaptive T cell tuning in immune regulation and immunotherapy of autoimmune diseases✰

David C Wraith

Immunology and Immunotherapy

Research output: Contribution to journal › Review article › peer-review

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Abstract

Lymphocyte receptors confer antigen specificity on the adaptive immune response. Increasing evidence points to the role of adaptive tuning particularly amongst CD4+ T cell responses. This review summarises how T cell tuning impacts on critically important aspects of immune regulation including thymic selection, the immune response to chronic antigen exposure and antigen-specific immunotherapy of autoimmune conditions. Recent work has revealed a novel mechanism for T cell anergy and regulatory type 1 T cell differentiation through a limitation of T cell receptor mediated signalling combined with epigenetic priming of tolerance associated genes.

Original language	English
Pages (from-to)	12-18
Number of pages	7
Journal	Immunology Letters
Volume	244
Early online date	26 Feb 2022
DOIs	https://doi.org/10.1016/j.imlet.2022.02.007
Publication status	Published - Apr 2022

Keywords

Autoimmune Diseases/therapy
Humans
Immune Tolerance
Immunologic Factors
Immunotherapy
Receptors, Antigen, T-Cell
T-Lymphocytes

Access to Document

10.1016/j.imlet.2022.02.007Licence: Creative Commons: Attribution (CC BY)

1-s2.0-S0165247822000268-mainFinal published version, 1.48 MBLicence: Creative Commons: Attribution (CC BY)

Defining peptide epitopes of islet antigens for detailed characterisation and immunotherapy of type 1 diabetes
Wraith, D. & Narendran, P.
Diabetes Uk
2/07/18 → 31/10/22
Project: Research
Definning peptide epitopes of islet for immunotherapy of type 1 diabetes
Narendran, P. & Wraith, D.
HELMSLEY TRUST
1/04/18 → 30/04/22
Project: Research

Cite this

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AB - Lymphocyte receptors confer antigen specificity on the adaptive immune response. Increasing evidence points to the role of adaptive tuning particularly amongst CD4+ T cell responses. This review summarises how T cell tuning impacts on critically important aspects of immune regulation including thymic selection, the immune response to chronic antigen exposure and antigen-specific immunotherapy of autoimmune conditions. Recent work has revealed a novel mechanism for T cell anergy and regulatory type 1 T cell differentiation through a limitation of T cell receptor mediated signalling combined with epigenetic priming of tolerance associated genes.

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KW - Immune Tolerance

KW - Immunologic Factors

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JO - Immunology Letters

JF - Immunology Letters

ER -

Adaptive T cell tuning in immune regulation and immunotherapy of autoimmune diseases✰

Abstract

Keywords

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Projects

Defining peptide epitopes of islet antigens for detailed characterisation and immunotherapy of type 1 diabetes

Definning peptide epitopes of islet for immunotherapy of type 1 diabetes

Cite this