Abstract
Since the early 1990s asymmetric catalytic applications of chiral, azetidine-derived, ligands and organocatalysts have been developed and utilised to engender asymmetry in reactions including Friedel-Crafts alkylations, Henry reactions and Michael-type reactions. This review surveys the effective synthetic opportunities presented by chiral azetidines in asymmetric catalysis. In order to benchmark, contrast and evaluate these asymmetric azetidine-containing catalysts, comparisons with aziridine- and pyrrolidine-containing analogues are drawn.
Original language | English |
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Article number | 131767 |
Journal | Tetrahedron |
Volume | 77 |
Early online date | 18 Nov 2020 |
DOIs | |
Publication status | Published - 1 Jan 2021 |
Bibliographical note
Funding Information:JPM and JSF would like to thank the University of Birmingham for support. JPM and JSF thank members of our research group for assistance in the latter stages of manuscript preparation.
Publisher Copyright:
© 2020
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
Keywords
- Asymmetric catalysis
- AzePhenol
- Azetidines
- Aziridines
- ProPhenol
- Pyrrolidines
ASJC Scopus subject areas
- Organic Chemistry