Validation of diffuse correlation spectroscopy measures of critical closing pressure against transcranial Doppler ultrasound in stroke patients

Kuan-Cheng Wu; John Sunwoo; Faheem Sheriff; Parisa Farzam; Parya Y. Farzam; Felipe Orihuela-Espina; Sarah L. LaRose; Andrew D. Monk; Mohammed Ali Aziz-Sultan; Nirav Patel; Henrikas Vaitkevicius; Maria Angela Franceschini

doi:10.1117/1.jbo.26.3.036008

Validation of diffuse correlation spectroscopy measures of critical closing pressure against transcranial Doppler ultrasound in stroke patients

Kuan-Cheng Wu, John Sunwoo, Faheem Sheriff, Parisa Farzam, Parya Y. Farzam, Felipe Orihuela-Espina, Sarah L. LaRose, Andrew D. Monk, Mohammed Ali Aziz-Sultan, Nirav Patel, Henrikas Vaitkevicius, Maria Angela Franceschini

Computer Science

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Abstract

Significance: Intracranial pressure (ICP), variability in perfusion, and resulting ischemia are leading causes of secondary brain injury in patients treated in the neurointensive care unit. Continuous, accurate monitoring of cerebral blood flow (CBF) and ICP guide intervention and ultimately reduce morbidity and mortality. Currently, only invasive tools are used to monitor patients at high risk for intracranial hypertension.

Aim: Diffuse correlation spectroscopy (DCS), a noninvasive near-infrared optical technique, is emerging as a possible method for continuous monitoring of CBF and critical closing pressure (CrCP or zero-flow pressure), a parameter directly related to ICP.

Approach: We optimized DCS hardware and algorithms for the quantification of CrCP. Toward its clinical translation, we validated the DCS estimates of cerebral blood flow index (CBFi) and CrCP in ischemic stroke patients with respect to simultaneously acquired transcranial Doppler ultrasound (TCD) cerebral blood flow velocity (CBFV) and CrCP.

Results: We found CrCP derived from DCS and TCD were highly linearly correlated (ipsilateral R² = 0.77, p = 9 × 10 ^− 7; contralateral R² = 0.83, p = 7 × 10 ^− 8). We found weaker correlations between CBFi and CBFV (ipsilateral R² = 0.25, p = 0.03; contralateral R² = 0.48, p = 1 × 10 ^− 3) probably due to the different vasculature measured.

Conclusion: Our results suggest DCS is a valid alternative to TCD for continuous monitoring of CrCP.

Original language	English
Article number	036008
Number of pages	14
Journal	Journal of Biomedical Optics
Volume	26
Issue number	3
DOIs	https://doi.org/10.1117/1.jbo.26.3.036008
Publication status	Published - 27 Mar 2021

Keywords

critical closing pressure
diffuse correlation spectroscopy
intracranial pressure
ischemic stroke
near-infrared spectroscopy

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WuK2021ValidationFinal published version, 1.82 MBLicence: Creative Commons: Attribution (CC BY)

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Wu, K-C., Sunwoo, J., Sheriff, F., Farzam, P., Farzam, P. Y., Orihuela-Espina, F., LaRose, S. L., Monk, A. D., Aziz-Sultan, M. A., Patel, N., Vaitkevicius, H., & Franceschini, M. A. (2021). Validation of diffuse correlation spectroscopy measures of critical closing pressure against transcranial Doppler ultrasound in stroke patients. Journal of Biomedical Optics, 26(3), Article 036008. https://doi.org/10.1117/1.jbo.26.3.036008

@article{016419305f35414eae62b039fae1cd67,

title = "Validation of diffuse correlation spectroscopy measures of critical closing pressure against transcranial Doppler ultrasound in stroke patients",

abstract = "Significance: Intracranial pressure (ICP), variability in perfusion, and resulting ischemia are leading causes of secondary brain injury in patients treated in the neurointensive care unit. Continuous, accurate monitoring of cerebral blood flow (CBF) and ICP guide intervention and ultimately reduce morbidity and mortality. Currently, only invasive tools are used to monitor patients at high risk for intracranial hypertension.Aim: Diffuse correlation spectroscopy (DCS), a noninvasive near-infrared optical technique, is emerging as a possible method for continuous monitoring of CBF and critical closing pressure (CrCP or zero-flow pressure), a parameter directly related to ICP.Approach: We optimized DCS hardware and algorithms for the quantification of CrCP. Toward its clinical translation, we validated the DCS estimates of cerebral blood flow index (CBFi) and CrCP in ischemic stroke patients with respect to simultaneously acquired transcranial Doppler ultrasound (TCD) cerebral blood flow velocity (CBFV) and CrCP.Results: We found CrCP derived from DCS and TCD were highly linearly correlated (ipsilateral R2 = 0.77, p = 9 × 10 − 7; contralateral R2 = 0.83, p = 7 × 10 − 8). We found weaker correlations between CBFi and CBFV (ipsilateral R2 = 0.25, p = 0.03; contralateral R2 = 0.48, p = 1 × 10 − 3) probably due to the different vasculature measured.Conclusion: Our results suggest DCS is a valid alternative to TCD for continuous monitoring of CrCP.",

keywords = "critical closing pressure, diffuse correlation spectroscopy, intracranial pressure, ischemic stroke, near-infrared spectroscopy",

author = "Kuan-Cheng Wu and John Sunwoo and Faheem Sheriff and Parisa Farzam and Farzam, {Parya Y.} and Felipe Orihuela-Espina and LaRose, {Sarah L.} and Monk, {Andrew D.} and Aziz-Sultan, {Mohammed Ali} and Nirav Patel and Henrikas Vaitkevicius and Franceschini, {Maria Angela}",

year = "2021",

month = mar,

day = "27",

doi = "10.1117/1.jbo.26.3.036008",

language = "English",

volume = "26",

journal = "Journal of Biomedical Optics",

issn = "1083-3668",

publisher = "Society of Photo-Optical Instrumentation Engineers",

number = "3",

}

Wu, K-C, Sunwoo, J, Sheriff, F, Farzam, P, Farzam, PY, Orihuela-Espina, F, LaRose, SL, Monk, AD, Aziz-Sultan, MA, Patel, N, Vaitkevicius, H & Franceschini, MA 2021, 'Validation of diffuse correlation spectroscopy measures of critical closing pressure against transcranial Doppler ultrasound in stroke patients', Journal of Biomedical Optics, vol. 26, no. 3, 036008. https://doi.org/10.1117/1.jbo.26.3.036008

TY - JOUR

T1 - Validation of diffuse correlation spectroscopy measures of critical closing pressure against transcranial Doppler ultrasound in stroke patients

AU - Wu, Kuan-Cheng

AU - Sunwoo, John

AU - Sheriff, Faheem

AU - Farzam, Parisa

AU - Farzam, Parya Y.

AU - Orihuela-Espina, Felipe

AU - LaRose, Sarah L.

AU - Monk, Andrew D.

AU - Aziz-Sultan, Mohammed Ali

AU - Patel, Nirav

AU - Vaitkevicius, Henrikas

AU - Franceschini, Maria Angela

PY - 2021/3/27

Y1 - 2021/3/27

N2 - Significance: Intracranial pressure (ICP), variability in perfusion, and resulting ischemia are leading causes of secondary brain injury in patients treated in the neurointensive care unit. Continuous, accurate monitoring of cerebral blood flow (CBF) and ICP guide intervention and ultimately reduce morbidity and mortality. Currently, only invasive tools are used to monitor patients at high risk for intracranial hypertension.Aim: Diffuse correlation spectroscopy (DCS), a noninvasive near-infrared optical technique, is emerging as a possible method for continuous monitoring of CBF and critical closing pressure (CrCP or zero-flow pressure), a parameter directly related to ICP.Approach: We optimized DCS hardware and algorithms for the quantification of CrCP. Toward its clinical translation, we validated the DCS estimates of cerebral blood flow index (CBFi) and CrCP in ischemic stroke patients with respect to simultaneously acquired transcranial Doppler ultrasound (TCD) cerebral blood flow velocity (CBFV) and CrCP.Results: We found CrCP derived from DCS and TCD were highly linearly correlated (ipsilateral R2 = 0.77, p = 9 × 10 − 7; contralateral R2 = 0.83, p = 7 × 10 − 8). We found weaker correlations between CBFi and CBFV (ipsilateral R2 = 0.25, p = 0.03; contralateral R2 = 0.48, p = 1 × 10 − 3) probably due to the different vasculature measured.Conclusion: Our results suggest DCS is a valid alternative to TCD for continuous monitoring of CrCP.

AB - Significance: Intracranial pressure (ICP), variability in perfusion, and resulting ischemia are leading causes of secondary brain injury in patients treated in the neurointensive care unit. Continuous, accurate monitoring of cerebral blood flow (CBF) and ICP guide intervention and ultimately reduce morbidity and mortality. Currently, only invasive tools are used to monitor patients at high risk for intracranial hypertension.Aim: Diffuse correlation spectroscopy (DCS), a noninvasive near-infrared optical technique, is emerging as a possible method for continuous monitoring of CBF and critical closing pressure (CrCP or zero-flow pressure), a parameter directly related to ICP.Approach: We optimized DCS hardware and algorithms for the quantification of CrCP. Toward its clinical translation, we validated the DCS estimates of cerebral blood flow index (CBFi) and CrCP in ischemic stroke patients with respect to simultaneously acquired transcranial Doppler ultrasound (TCD) cerebral blood flow velocity (CBFV) and CrCP.Results: We found CrCP derived from DCS and TCD were highly linearly correlated (ipsilateral R2 = 0.77, p = 9 × 10 − 7; contralateral R2 = 0.83, p = 7 × 10 − 8). We found weaker correlations between CBFi and CBFV (ipsilateral R2 = 0.25, p = 0.03; contralateral R2 = 0.48, p = 1 × 10 − 3) probably due to the different vasculature measured.Conclusion: Our results suggest DCS is a valid alternative to TCD for continuous monitoring of CrCP.

KW - critical closing pressure

KW - diffuse correlation spectroscopy

KW - intracranial pressure

KW - ischemic stroke

KW - near-infrared spectroscopy

UR - http://www.scopus.com/inward/record.url?scp=85103522881&partnerID=8YFLogxK

U2 - 10.1117/1.jbo.26.3.036008

DO - 10.1117/1.jbo.26.3.036008

M3 - Article

SN - 1083-3668

VL - 26

JO - Journal of Biomedical Optics

JF - Journal of Biomedical Optics

IS - 3

M1 - 036008

ER -

Validation of diffuse correlation spectroscopy measures of critical closing pressure against transcranial Doppler ultrasound in stroke patients

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Keywords

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