Graham Anderson

Accepting PhD Students

PhD projects

Graham Anderson’s laboratory is interested in the mechanisms that regulate the generation of a self-tolerant T cell pool. These events occur within the thymus, an organ that provides specialised microenvironments to support the development of mature T cells from their bone marrow-derived precursors. In particular, epithelial cells within the thymus provide essential signals to these migrant precursors that regulate their proliferation, commitment and differentiation. Defects in thymic epithelial cell development and function are known to be linked to autoimmunity and immunodeficiency, making analysis of these cells important in understanding normal immune system development and function.

Professor Anderson supervises doctoral research students in the areas of thymus biology and T cell development.

Research activity per year

175 Article
12 Review article
5 Comment/debate
2 Chapter
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1 - 50 out of 198 results

2024
Developmental conversion of thymocyte-attracting cells into self-antigen-displaying cells in embryonic thymus medulla epithelium
Ohigashi, I., White, A. J., Yang, M-T., Fujimori, S., Tanaka, Y., Jacques, A., Kiyonari, H., Matsushita, Y., Turan, S., Kelly, M. C., Anderson, G. & Takahama, Y., 11 Mar 2024, In: eLife. 12, 24 p., 92552.
Research output: Contribution to journal › Article › peer-review

Open Access
File
2023
Assembling the thymus medulla: Development and function of epithelial cell heterogeneity
James, K. D., Cosway, E. J., Parnell, S. M., White, A. J., Jenkinson, W. E. & Anderson, G., 31 Dec 2023, (E-pub ahead of print) In: BioEssays. 11 p., 2300165.
Research output: Contribution to journal › Review article › peer-review

Open Access
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1 Downloads (Pure)
Combined multidimensional single-cell protein and RNA profiling dissects the cellular and functional heterogeneity of thymic epithelial cells
Klein, F., Veiga-Villauriz, C., Börsch, A., Maio, S., Palmer, S., Dhalla, F., Handel, A. E., Zuklys, S., Calvo-Asensio, I., Musette, L., Deadman, M. E., White, A. J., Lucas, B., Anderson, G. & Holländer, G. A., 10 Jul 2023, In: Nature Communications. 14, 1, 16 p., 4071.
Research output: Contribution to journal › Article › peer-review

Open Access
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33 Downloads (Pure)
Developmental conversion of thymocyte-attracting cells into self-antigen-displaying cells in embryonic thymus medulla epithelium
Ohigashi, I., White, A. J., Yang, M-T., Fujimori, S., Tanaka, Y., Jacques, A., Kiyonari, H., Matsushita, Y., Turan, S., Kelly, M. C., Anderson, G. & Takahama, Y., 4 Oct 2023, bioRxiv.
Research output: Working paper/Preprint › Preprint
Diversity in Cortical Thymic Epithelial Cells Occurs through Loss of a Foxn1-Dependent Gene Signature Driven by Stage-Specific Thymocyte Cross-Talk
White, A. J., Parnell, S. M., Handel, A., Maio, S., Bacon, A., Cosway, E. J., Lucas, B., James, K. D., Cowan, J. E., Jenkinson, W. E., Hollander, G. A. & Anderson, G., 1 Jan 2023, In: Journal of Immunology. 210, 1, p. 40-49 10 p.
Research output: Contribution to journal › Article › peer-review

Open Access
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28 Downloads (Pure)
Embryonic keratin19+ progenitors generate multiple functionally distinct progeny to maintain epithelial diversity in the adult thymus medulla
Lucas, B., White, A. J., Klein, F., Veiga-Villauriz, C., Handel, A., Bacon, A., Cosway, E. J., James, K. D., Parnell, S. M., Ohigashi, I., Takahama, Y., Jenkinson, W. E., Hollander, G. A., Lu, W-Y. & Anderson, G., 12 Apr 2023, In: Nature Communications. 14, 1, 14 p., 2066.
Research output: Contribution to journal › Article › peer-review

Open Access
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20 Downloads (Pure)
The alarmin IL33 orchestrates type 2 immune-mediated control of thymus regeneration
Cosway, E. J., James, K. D., White, A. J., Parnell, S. M., Bacon, A., McKenzie, A. N. J., Jenkinson, W. E. & Anderson, G., 8 Nov 2023, In: Nature Communications. 14, 1, 11 p., 7201.
Research output: Contribution to journal › Article › peer-review

Open Access
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21 Downloads (Pure)
The medulla controls effector primed γδT-cell development in the adult mouse thymus
James, K. D., White, A. J., Jenkinson, W. E. & Anderson, G., 6 Jun 2023, In: European Journal of Immunology. 53, 6, e2350388.
Research output: Contribution to journal › Article › peer-review

Open Access
File
10 Downloads (Pure)
2022
Eosinophils are an essential element of a type 2 immune axis that controls thymus regeneration
Cosway, E. J., White, A. J., Parnell, S. M., Schweighoffer, E., Jolin, H. E., Bacon, A., Rodewald, H. R., Tybulewicz, V., McKenzie, A. N. J., Jenkinson, W. E. & Anderson, G., 11 Mar 2022, In: Science Immunology. 7, 69, 12 p., eabn3286.
Research output: Contribution to journal › Article › peer-review
7 Citations (Scopus)
G-CSF induces CD15⁺ CD14⁺ cells from granulocytes early in the physiological environment of pregnancy and the cancer immunosuppressive microenvironment
Maneta, E., Fultang, L., Taylor, J., Pugh, M., Jenkinson, W., Anderson, G., Coomarasamy, A., Kilby, M. D., Lissauer, D. M., Mussai, F. & De Santo, C., 17 May 2022, In: Clinical and Translational Immunology. 11, 5, 12 p., e1395.
Research output: Contribution to journal › Article › peer-review

Open Access
File
82 Downloads (Pure)
2021
A novel method to identify Post-Aire stages of medullary thymic epithelial cell differentiation
Ferreirinha, P., Ribeiro, C., Morimoto, J., Landry, J. J. M., Matsumoto, M., Meireles, C., White, A. J., Ohigashi, I., Araújo, L., Benes, V., Takahama, Y., Anderson, G., Matsumoto, M. & Alves, N. L., Feb 2021, In: European Journal of Immunology. 51, 2, p. 311-318 8 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
2 Downloads (Pure)
Failures in thymus medulla regeneration during immune recovery cause tolerance loss and prime recipients for auto-GVHD
Alawam, A. S., Cosway, E. J., James, K. D., Lucas, B., Bacon, A., Parnell, S. M., White, A. J., Jenkinson, W. E. & Anderson, G., 15 Dec 2021, In: The Journal of Experimental Medicine. 219, 2, 15 p., e20211239.
Research output: Contribution to journal › Article › peer-review

Open Access
File
55 Downloads (Pure)
FOXN1 forms higher-order nuclear condensates displaced by mutations causing immunodeficiency
Rota, I. A., Handel, A. E., Maio, S., Klein, F., Dhalla, F., Deadman, M. E., Cheuk, S., Newman, J. A., Michaels, Y. S., Zuklys, S., Prevot, N., Hublitz, P., Charles, P. D., Gkazi, A. S., Adamopoulou, E., Qasim, W., Davies, E. G., Hanson, I., Pagnamenta, A. T., Camps, C., & 11 othersDreau, H. M., White, A., James, K., Fischer, R., Gileadi, O., Taylor, J. C., Fulga, T., Christoffer Lagerholm, B., Anderson, G., Sezgin, E. & Holländer, G. A., 3 Dec 2021, In: Science Advances. 7, 49, 19 p., eabj9247.
Research output: Contribution to journal › Article › peer-review

Open Access
File
5 Citations (Scopus)

2 Downloads (Pure)
Medullary stromal cells synergize their production and capture of CCL21 for T-cell emigration from neonatal mouse thymus
James, K. D., Legler, D. F., Purvanov, V., Ohigashi, I., Takahama, Y., Parnell, S. M., White, A. J., Jenkinson, W. E. & Anderson, G., 12 Jan 2021, In: Blood Advances. 5, 1, p. 99-112 14 p.
Research output: Contribution to journal › Article › peer-review
10 Citations (Scopus)
Non-Epithelial Stromal Cells in Thymus Development and Function
James, K. D., Jenkinson, W. E. & Anderson, G., 25 Feb 2021, In: Frontiers in immunology. 12, 634367.
Research output: Contribution to journal › Review article › peer-review

Open Access
File
1 Citation (Scopus)

142 Downloads (Pure)
RANK links thymic regulatory T cells to fetal loss and gestational diabetes in pregnancy
Paolino, M., Koglgruber, R., Cronin, S. J. F., Uribesalgo, I., Rauscher, E., Harreiter, J., Schuster, M., Bancher-Todesca, D., Pranjic, B., Novatchkova, M., Fededa, J. P., White, A. J., Sigl, V., Dekan, S., Penz, T., Bock, C., Kenner, L., Holländer, G. A., Anderson, G., Kautzky-Willer, A., & 1 othersPenninger, J. M., 21 Jan 2021, In: Nature. 589, 7842, p. 442-447 6 p.
Research output: Contribution to journal › Article › peer-review
42 Citations (Scopus)
The thymus medulla and its control of αβT cell development
Cosway, E. J., James, K. D., Lucas, B., Anderson, G. & White, A. J., 1 Feb 2021, In: Seminars in immunopathology. 43, 1, p. 15-27 13 p.
Research output: Contribution to journal › Review article › peer-review

Open Access
File
1 Citation (Scopus)

153 Downloads (Pure)
2020
Active module identification from multilayer weighted gene co-expression networks: a continuous optimization approach
Li, D., Pan, Z., Hu, G., Anderson, G. & He, S., 30 Jan 2020, (E-pub ahead of print) In: IEEE/ACM Transactions on Computational Biology and Bioinformatics. 10 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
340 Downloads (Pure)
A population of proinflammatory T cells coexpresses αβ and γδ T cell receptors in mice and humans
Edwards, S. C., Sutton, C. E., Ladell, K., Grant, E. J., McLaren, J. E., Roche, F., Dash, P., Apiwattanakul, N., Awad, W., Miners, K. L., Lalor, S. J., Ribot, J. C., Baik, S., Moran, B., McGinley, A., Pivorunas, V., Dowding, L., Macoritto, M., Paez-Cortez, J., Slavin, A., & 7 othersAnderson, G., Silva-Santos, B., Hokamp, K., Price, D. A., Thomas, P. G., McLoughlin, R. M. & Mills, K. H. G., 4 May 2020, In: Journal of Experimental Medicine. 217, 5, e20190834.
Research output: Contribution to journal › Article › peer-review

Open Access
21 Citations (Scopus)
Critical role of wnk1 in myc-dependent early mouse thymocyte development
Köchl, R., Vanes, L., Sopena, M. L., Chakravarty, P., Hartweger, H., Fountain, K., White, A., Cowan, J., Anderson, G. & Tybulewicz, V. L. J., Oct 2020, In: eLife. 9, p. 1-32 32 p., e56934.
Research output: Contribution to journal › Article › peer-review

Open Access
4 Citations (Scopus)
Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells
Lucas, B., White, A. J., Cosway, E. J., Parnell, S. M., James, K. D., Jones, N. D., Ohigashi, I., Takahama, Y., Jenkinson, W. E. & Anderson, G., Dec 2020, In: Nature Communications. 11, 1, 14 p., 2198.
Research output: Contribution to journal › Article › peer-review

Open Access
File
10 Citations (Scopus)

169 Downloads (Pure)
Erratum: Correction: Tissue-specific shaping of the TCR repertoire and antigen specificity of iNKT cells (eLife (2019) 8 PII: e56997)
Jimeno, R., Lebrusant-Fernandez, M., Margreitter, C., Lucas, B., Veerapen, N., Besra, G. S., Fraternali, F., Spencer, J., Anderson, G. & Barral, P., 18 Mar 2020, In: eLife. 9, e56997.
Research output: Contribution to journal › Comment/debate › peer-review

Open Access
Generation and Regeneration of Thymic Epithelial Cells
Alawam, A. S., Anderson, G. & Lucas, B., 7 May 2020, In: Frontiers in immunology. 11, 858.
Research output: Contribution to journal › Review article › peer-review

Open Access
File
6 Citations (Scopus)

205 Downloads (Pure)
Homeostatic Cytokines Drive Epigenetic Reprogramming of Activated T Cells into a "Naive-Memory" Phenotype
Frumento, G., Verma, K., Croft, W., White, A., Zuo, J., Nagy, Z., Kissane, S., Anderson, G., Moss, P. & Chen, F. E., 24 Apr 2020, In: iScience. 23, 4, 100989.
Research output: Contribution to journal › Article › peer-review

Open Access
File
2 Citations (Scopus)

197 Downloads (Pure)
Nr4a1 and Nr4a3 reporter mice are differentially sensitive to T cell receptor signal strength and duration
Jennings, E., Elliot, T., Thawait, N., Kanabar, S., Yam-Puc, J. C., Ono, M., Toellner, K-M., Wraith, D. C., Anderson, G. & Bending, D., 3 Nov 2020, In: Cell Reports. 33, 5, 108328.
Research output: Contribution to journal › Article › peer-review

Open Access
File
1 Citation (Scopus)

216 Downloads (Pure)
Thymic Engraftment by in vitro-Derived Progenitor T Cells in Young and Aged Mice
Singh, J., Mohtashami, M., Anderson, G. & Zúñiga-Pflücker, J. C., 18 Aug 2020, In: Frontiers in immunology. 11, 1850.
Research output: Contribution to journal › Article › peer-review

Open Access
7 Citations (Scopus)
2019
CXCR4, but not CXCR3, drives CD8 ⁺ T-cell entry into and migration through the murine bone marrow
Goedhart, M., Gessel, S., van der Voort, R., Slot, E., Lucas, B., Gielen, E., Hoogenboezem, M., Rademakers, T., Geerman, S., van Buul, J. D., Huveneers, S., Dolstra, H., Anderson, G., Voermans, C. & Nolte, M. A., Apr 2019, In: European Journal of Immunology. 49, 4, p. 576-589 14 p.
Research output: Contribution to journal › Article › peer-review

Open Access
Rethinking Thymic Tolerance: Lessons from Mice
Inglesfield, S., Cosway, E. J., Jenkinson, W. E. & Anderson, G., Apr 2019, In: Trends in Immunology. 40, 4, p. 279-291 13 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File

20 Citations (Scopus)

182 Downloads (Pure)
Tissue-specific shaping of the TCR repertoire and antigen specificity of iNKT cells
Jimeno, R., Lebrusant-Fernandez, M., Margreitter, C., Lucas, B., Veerapen, N., Kelly, G., Besra, G. S., Fraternali, F., Spencer, J., Anderson, G. & Barral, P., 16 Dec 2019, In: eLife. 8, 23 p., e51663.
Research output: Contribution to journal › Article › peer-review

Open Access
File
4 Citations (Scopus)

210 Downloads (Pure)
2018
Aire controls the recirculation of murine Foxp3+ regulatory T-cells back to the thymus
Cowan, J. E., Baik, S., McCarthy, N. I., Parnell, S. M., White, A. J., Jenkinson, W. E. & Anderson, G., May 2018, In: European Journal of Immunology. 48, 5, p. 844-854
Research output: Contribution to journal › Article › peer-review

Open Access
File
12 Citations (Scopus)

192 Downloads (Pure)
Bruno Kyewski (1950-2018)
Anderson, G., 16 May 2018, In: European Journal of Immunology. 48, 5, 2 p.
Research output: Contribution to journal › Editorial

1 Citation (Scopus)
Dynamic changes in intrathymic ILC populations during murine neonatal development
Jones, R., Cosway, E., Willis, C., White, A., Jenkinson, W., Fehling, H. J., Anderson, G. & Withers, D., 3 Sept 2018, In: European Journal of Immunology. 48, 9, p. 1481-1491 11 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
18 Citations (Scopus)

177 Downloads (Pure)
Endothelial cells act as gatekeepers for LTβR-dependent thymocyte emigration
James, K. D., Cosway, E. J., Lucas, B., White, A. J., Parnell, S. M., Carvalho-Gaspar, M., Tumanov, A. V., Anderson, G. & Jenkinson, W. E., 3 Dec 2018, In: The Journal of Experimental Medicine. 215, 12, p. 2984-2993 8 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
9 Citations (Scopus)

210 Downloads (Pure)
Formation of the Intrathymic Dendritic Cell Pool Requires CCL21-Mediated Recruitment of CCR7⁺ Progenitors to the Thymus
Cosway, E., Ohigashi, I., Schauble, K., Parnell, S., Jenkinson, W., Luther, S. A., Takahama, Y. & Anderson, G., 15 Jul 2018, In: Journal of Immunology. 201, 2, p. 516-523
Research output: Contribution to journal › Article › peer-review

Open Access
File
16 Citations (Scopus)

164 Downloads (Pure)
IgG Responses to Porins and Lipopolysaccharide within an Outer Membrane-Based Vaccine against Nontyphoidal Develop at Discordant Rates
Schager, A., Dominguez-Medina, C. C., Necchi, F., Micoli, F., Goh, Y. S., Goodall, M., Flores-Langarica, A., Bobat, S., Cook, C., Arcuri, M., Marini, A., King, L. D. W., Morris, F., Anderson, G., Toellner, K-M., Henderson, I., López-Macías, C., MacLennan, C. A. & Cunningham, A., 6 Mar 2018, In: mBio. 9, 2, e02379-17.
Research output: Contribution to journal › Article › peer-review

Open Access
File
13 Citations (Scopus)

243 Downloads (Pure)
Increased Production of IL-17A-Producing γδ T Cells in the Thymus of Filaggrin-Deficient Mice
Jee, M. H., Johansen, J. D., Buus, T. B., Petersen, T. H., Gadsbøll, A-S. Ø., Woetmann, A., Ødum, N., Thyssen, J. P., White, A., Anderson, G., Geisler, C. & Bonefeld, C. M., 8 May 2018, In: Frontiers in immunology. 9, p. 988
Research output: Contribution to journal › Article › peer-review

Open Access
File
7 Citations (Scopus)

170 Downloads (Pure)
Invariant NKT Cells and Control of the Thymus Medulla
White, A., Lucas, B., Jenkinson, W. & Anderson, G., 15 May 2018, In: Journal of Immunology. 200, 10, p. 3333-3339 7 p.
Research output: Contribution to journal › Review article › peer-review
8 Citations (Scopus)
Retinoic Acid Signaling in Thymic Epithelial Cells Regulates Thymopoiesis
Wendland, K., Niss, K., Kotarsky, K., Wu, N. Y. H., White, A., Jendholm, J., Rivollier, A., Izarzugaza, J. M. G., Brunak, S., Holländer, G. A., Anderson, G., Sitnik, K. M. & Agace, W. W., 1 Jul 2018, In: Journal of Immunology.
Research output: Contribution to journal › Article › peer-review
9 Citations (Scopus)
T-cell egress from the thymus: should I stay or should I go?
James, K. D., Jenkinson, W. E. & Anderson, G., Aug 2018, In: Journal of Leukocyte Biology. 104, 2, p. 275-284
Research output: Contribution to journal › Review article › peer-review

Open Access
File
14 Citations (Scopus)

206 Downloads (Pure)
2017
A type 2 cytokine axis for thymus emigration
White, A. J., Baik, S., Parnell, S. M., Holland, A. M., Brombacher, F., Jenkinson, W. E. & Anderson, G., 10 Jul 2017, In: The Journal of Experimental Medicine. 214, 8, p. 2205–2216
Research output: Contribution to journal › Article › peer-review

Open Access
File
25 Citations (Scopus)

165 Downloads (Pure)
Generation of diversity in thymic epithelial cells
Takahama, Y., Ohigashi, I., Baik, S. & Anderson, G., 20 Mar 2017, (E-pub ahead of print) In: Nature Reviews Immunology. 17, p. 295-305 11 p.
Research output: Contribution to journal › Review article › peer-review

Open Access
File
74 Citations (Scopus)

700 Downloads (Pure)
Medullary Thymic epithelial cell progenitors: hidden in plain sight
Anderson, G., Jun 2017, In: Nature Reviews Immunology. 17, 6, p. 348
Research output: Contribution to journal › Book/Film/Article review
Prdm1 Regulates Thymic Epithelial Function To Prevent Autoimmunity
Roberts, N. A., Adams, B. D., McCarthy, N. I., Tooze, R. M., Parnell, S. M., Anderson, G., Kaech, S. M. & Horsley, V., 7 Aug 2017, In: Journal of Immunology. 199, 4, p. 1250-1260 11 p.
Research output: Contribution to journal › Article › peer-review

Open Access
11 Citations (Scopus)
Progressive Changes in CXCR4 Expression That Define Thymocyte Positive Selection Are Dispensable For Both Innate and Conventional αβT-cell Development
Lucas, B., White, A. J., Parnell, S. M., Henley, P. M., Jenkinson, W. E. & Anderson, G., 11 Jul 2017, In: Scientific Reports. 7, 1, 5068.
Research output: Contribution to journal › Article › peer-review

Open Access
File
6 Citations (Scopus)

187 Downloads (Pure)
Redefining thymus medulla specialization for central tolerance
Cosway, E. J., Lucas, B., James, K. D., Parnell, S. M., Carvalho-Gaspar, M., White, A. J., Tumanov, A. V., Jenkinson, W. & Anderson, G., 22 Aug 2017, In: The Journal of Experimental Medicine. 214, 11, p. 3183-3195
Research output: Contribution to journal › Article › peer-review

Open Access
File
37 Citations (Scopus)

232 Downloads (Pure)
Thymic Epithelial Cells
Anderson, G., Apr 2017, In: Annual review of immunology. 35, p. 85-118
Research output: Contribution to journal › Review article › peer-review
112 Citations (Scopus)
2016
Affinity for self antigen selects T_reg cells with distinct functional properties
Wyss, L., Stadinski, B. D., King, C. G., Schallenberg, S., McCarthy, N. I., Lee, J. Y., Kretschmer, K., Terracciano, L. M., Anderson, G., Surh, C. D., Huseby, E. S. & Palmer, E., Sept 2016, In: Nature Immunology. 17, 9, p. 1093–1101 9 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
44 Citations (Scopus)

525 Downloads (Pure)
CCR7 controls thymus recirculation, but not production and emigration, of Foxp3⁺ T cells
Cowan, J., McCarthy, N. & Anderson, G., 9 Feb 2016, In: Cell Reports. 14, 5, p. 1041–1048 8 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
37 Citations (Scopus)

135 Downloads (Pure)
Context-Dependent Development of Lymphoid Stroma from Adult CD34(+) Adventitial Progenitors
Sitnik, K. M., Wendland, K., Weishaupt, H., Uronen-Hansson, H., White, A., Anderson, G., Kotarsky, K. & Agace, W. W., 15 Mar 2016, In: Cell Reports. 14, 10, p. 2375-2388 14 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
37 Citations (Scopus)

166 Downloads (Pure)
Control of the thymic medulla and its influence on αβT-cell development
Lucas, B., McCarthy, N. I., Baik, S., Cosway, E., James, K. D., Parnell, S. M., White, A. J., Jenkinson, W. E. & Anderson, G., May 2016, In: Immunological Reviews. 271, 1, p. 23-37 15 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
12 Citations (Scopus)

149 Downloads (Pure)

Graham Anderson

Research output

Search results