Research output per year
Research output per year
Personal profile
Biography
Dr. David Hodson completed a degree in Veterinary Science before undertaking doctoral studies in reproductive physiology and circadian biology at the University of Bristol. Subsequently, in 2008, he moved to the laboratory of Dr. Patrice Mollard at the Institut de Genomique Fonctionnelle in Montpellier (CNRS), France, where, supported by a Fellowship from the Fondation de la Recherche Medicale (FRM), he pursued postdoctoral studies focused on understanding how endocrine cells residing within the mammalian pituitary gland function as three-dimensional networks to generate hormone release in response to demand. Following award of a Diabetes UK RD Lawrence Fellowship in 2012, David moved to the Department of Medine at Imperial College London, where he set up a reserach gropup devoted to understanding how type 2 diabetes (T2D) insults target tissue- and organ-level processes to impact beta cell function and reduce insulin secretion. In 2016, David moved to the newly-formed Insitute of Metabolism and Systems Research (IMSR) at the University of Birmingham to continue his studies at the forefront of endocrinology and diabetes research.
Research interests
Research in our lab revolves around the use of sophisticated imaging modalities (e.g. high-speed multibeam, two-photon, super-resolution), combined with recombinant technologies and genetic manipulation, to interrogate and decipher the population basis for hormone secretion from endocrine tissues in situ and in vivo. Focussing predominantly upon rodent and human islets of Langerhans, these studies have demonstrated a novel mode of incretin action which boosts insulin release through coaxing beta cell cooperativity, a role for GWAS-identified genes in regulating human beta cell-beta cell interconnectedness, and dual orchestration of metabolic dynamics in a subpopulation of beta cells by glucose and incretin. Currently, we are supported by Diabetes UK, MRC and EFSD.
Qualifications
2005 Bachelor of Veterinary Science with Honours (BVSc Hons)
2005 Member of the Royal College of Veterinary Surgeons (MRCVS)
2009 Doctor of Philosophy (PhD)
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Keywords
- QP Physiology
- Q Science (General)
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Collaborations and top research areas from the last five years
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LDHB contributes to the regulation of lactate levels and basal insulin secretion in human pancreatic β cells
Cuozzo, F., Viloria, K., Shilleh, A. H., Nasteska, D., Frazer-Morris, C., Tong, J., Jiao, Z., Boufersaoui, A., Marzullo, B., Rosoff, D. B., Smith, H. R., Bonner, C., Kerr-Conte, J., Pattou, F., Nano, R., Piemonti, L., Johnson, P. R. V., Spiers, R., Roberts, J., Lavery, G. G., & 13 others, 23 Apr 2024, In: Cell Reports. 43, 4, 114047.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Downloads (Pure) -
Architecture of androgen receptor pathways amplifying glucagon-like peptide-1 insulinotropic action in male pancreatic β cells
Xu, W., Qadir, M. M. F., Nasteska, D., Mota de Sa, P., Gorvin, C. M., Blandino-Rosano, M., Evans, C. R., Ho, T., Potapenko, E., Veluthakal, R., Ashford, F. B., Bitsi, S., Fan, J., Bhondeley, M., Song, K., Sure, V. N., Sakamuri, S. S. V. P., Schiffer, L., Beatty, W., Wyatt, R., & 15 others, 30 May 2023, In: Cell Reports. 42, 5, 29 p., 112529.Research output: Contribution to journal › Article › peer-review
Open AccessFile35 Downloads (Pure) -
Fine‐tuned photochromic sulfonylureas for optical control of beta cell Ca 2+ fluxes
Rückert, AK., Ast, J., Hasib, A., Nasteska, D., Viloria, K., Broichhagen, J. & Hodson, D. J., 5 Sept 2023, (E-pub ahead of print) In: Diabetic Medicine. 40, 12, 9 p., e15220.Research output: Contribution to journal › Article › peer-review
Open AccessFile26 Downloads (Pure) -
GC-Globulin/Vitamin D-Binding Protein Is Required for Pancreatic α-Cell Adaptation to Metabolic Stress
Viloria, K., Nasteska, D., Ast, J., Hasib, A., Cuozzo, F., Heising, S., Briant, L. J. B., Hewison, M. & Hodson, D. J., Feb 2023, In: Diabetes. 72, 2, p. 275-289 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
PEPITEM modulates leukocyte trafficking to reduce obesity-induced inflammation
Pezhman, L., Hopkin, S., Begum, J., Heising, S., Nasteska, D., Wahid, M., Rainger, E., Hodson, D., Iqbal, A. J., Chimen, M. & McGettrick, H., Apr 2023, In: Clinical & Experimental Immunology. uxad022.Research output: Contribution to journal › Article › peer-review
Open AccessFile43 Downloads (Pure)
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Coronary microcirculation and diabetes - pathophysiological role of the IL-36 / IL-36R pathway
Kavanagh, D., Kalia, N. & Hodson, D.
6/06/22 → 31/05/25
Project: Research
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Dissecting and leveraging glucagon-like peptide-1 brain pathways in obesity
1/09/21 → 31/08/23
Project: EU
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Investigating the role of immature beta cells in insulin release from the intact islet
Nasteska, D. & Hodson, D.
1/08/19 → 30/11/22
Project: Research
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Exploring beta cell reprogramming by glucocorticoids in health and disease
Hodson, D. & Lavery, G.
9/04/18 → 1/03/22
Project: Research
Prizes
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EFSD/Novo Nordisk Rising Star Fellowship
Hodson, David (Recipient), 2015
Prize: Prize (including medals and awards)